1. The Promising Ability of Humulus lupulus L. Iso-α-acids vs. Diabetes, Inflammation, and Metabolic Syndrome: A Systematic Review
- Author
-
Ludovica Lela, Daniela Russo, Luigi Milella, Chiara Sinisgalli, Immacolata Faraone, Maria Ponticelli, and Fabiana Labanca
- Subjects
Humulus lupulus ,medicine.medical_treatment ,Phytochemicals ,Pharmaceutical Science ,Review ,Bioinformatics ,Analytical Chemistry ,0302 clinical medicine ,Drug Discovery ,Glucose homeostasis ,030212 general & internal medicine ,Medical nutrition therapy ,0303 health sciences ,biology ,Beer ,food and beverages ,Chemistry (miscellaneous) ,Molecular Medicine ,medicine.symptom ,Humulus lupulus L ,Inflammation ,Flowers ,metabolic syndrome ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Humans ,Physical and Theoretical Chemistry ,Humulus ,030304 developmental biology ,reduced iso-α-acids ,iso-α-acids ,PPAR receptors ,business.industry ,Insulin ,Organic Chemistry ,Lipid metabolism ,medicine.disease ,biology.organism_classification ,Lipid Metabolism ,Metabolic syndrome ,business ,Acids - Abstract
For centuries, natural medicines have represented the only option for treating human diseases and, nowadays, plant phytochemicals are considered as promising compounds to treat or prevent chronic conditions. Among them, hop flowers (Humulus lupulus L.), typically used in brewing industries to give the typical aroma and flavor to beer, have attracted particular attention for their health promoting properties. Several in vivo/vitro studies and human interventional trials have demonstrated the beneficial effects of these molecules on weight gain, lipid metabolism, glucose homeostasis, insulin sensitivities, and inflammation by acting on different targets. All these activities suggest a possible role of bitter hop acid in preventing metabolic syndrome and its related diseases. A systematic quest on PubMed and Scopus databases was performed to identify pre-clinical and clinical studies focusing on this topic. This systematic review summarizes the results obtained by different cell lines, animal models, and human interventional trials to propose iso-α-acids as medical nutrition therapy to treat or prevent metabolic syndrome and its related disorders as diabetes, dislipidemia inflammation, etc.
- Published
- 2021