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This study seeks to develop a fundamental comprehension of the noise challenges encountered by commercial aircraft fuselage surface attachments, such as blade antennas and pitot tubes. The study examines the flow characteristics and far-field noise directivity of a wall-mounted NACA0012 airfoil with various sweep angles (−35°, −15°, 0°, +15°, and +35°) and an aspect ratio of 1.5. The Mach numbers of the incoming flow range from 0.8 to 0.9 with a Reynolds number of about 7 × 105. Delayed Detached Eddy Simulation (DDES) and the Ffowcs Williams–Hawkings (FW-H) equation are utilized. The results show that the shock wave intensity at the junction between the airfoil and the bottom wall is enhanced by the forward-swept angle. The shock wave moves and changes into a λ-type structure, while the boundary layer separates and produces shedding vortices in the junction at a smaller Mach number on the forward-swept airfoil compared to the straight airfoil and the backward-swept airfoil. These phenomena cause significant surface pressure fluctuations in the junction and result in a significant dipole noise in the far field, which is the primary source of noise in the far field. In addition, the normal Mach number and the absolute sweep angle also contribute to the far-field noise. [ABSTRACT FROM AUTHOR]

For noise reduction at a low-to-moderate Reynolds number, airfoil trailing-edge tonal noise has multiple prominent tones. Among these tones, secondary tones are greatly influenced by external disturbances such as oscillations commonly in the environment. In previous experiments, the spatial movement of sources was found to be related to an inherent high-frequency oscillation. Therefore, the spatial influence of external low-frequency oscillations was investigated in this study. By using tripping tapes to construct different symmetry source regions on the pressure side with side secondary tones, a transient spatial analysis of an NACA0012 airfoil at 2 degrees was performed by microphone arrays when a 10 Hz pressure oscillation was significant at 24 m/s. Temporally, this 10 Hz periodic strength change became more intense at a broader frequency bandwidth for a longer source region. Furthermore, a substantial time delay, significantly larger than the sound propagating time difference between microphones, was observed exclusively along the spanwise direction. This delay led to a periodic directivity pattern, particularly when two 0.2 m source regions were separated by a 0.2 m or 0.4 m tripping region. This low-frequency oscillation introduces an asymmetric transient switching pattern for symmetric spanwise source regions. Consequently, the response of airfoils to external oscillations in field tests should be considered. [ABSTRACT FROM AUTHOR]

This paper investigates the impact of varying the part geometric complexity and 3D printing process setup on the resulting structural load bearing capacity of fiber composites. Three levels of geometric complexity are developed through 2.5D topology optimization, 3D topology optimization, and 3D topology optimization with directional material removal. The 3D topology optimization is performed with the SIMP method and accelerated by high-performance computing. The directional material removal is realized by incorporating the advection-diffusion partial differential equation-based filter to prevent interior void or undercut in certain directions. A set of 3D printing and mechanical performance tests are performed. It is interestingly found that, the printing direction affects significantly on the result performance and if subject to the uni direction, the load-bearing capacity increases from the 2.5D samples to the 3D samples with the increased complexity, but the load-bearing capacity further increases for the 3D simplified samples due to directional material removal. Hence, it is concluded that a restricted structural complexity is suitable for topology optimization of 3D-printed fiber composites, since large area cross-sections give more degrees of design freedom to the fiber path layout and also makes the inter-layer bond of the filaments firmer. [ABSTRACT FROM AUTHOR]

Downy blight, caused by Peronophythora litchii, is a destructive disease that impacts lychee fruit throughout the pre-harvest, post-harvest, and transportation phases. Therefore, the prompt and precise identification of P. litchii is crucial for the effective management of the disease. A novel gene encoding a Rh-type ammonium transporter, Pl_101565, was identified in P. litchii through bioinformatic analysis in this study. Based on this gene, a coupled recombinase polymerase amplification–lateral flow (RPA-LF) assay for the rapid visual detection of P. litchii was developed. The assay has been shown to detect P. litchii accurately, without cross-reactivity to related pathogenic oomycetes or fungi. Moreover, it can be performed effectively within 15 to 25 min at temperatures ranging from 28 to 46 °C. Under optimized conditions, the RPA-LF assay could detect as low as 1 pg of P. litchii genomic DNA in a 25 μL reaction system. Furthermore, the RPA-LF assay successfully detected P. litchii in infected lychee samples within a 30 min timeframe. These attributes establish the RPA-LF assay as a rapid, sensitive, and specific method for diagnosing P. litchii early; it is particularly suitable for applications in resource-limited settings. [ABSTRACT FROM AUTHOR]

The flap side-edge is a vital contributor to airframe noise. In this study, we propose a novel flap side-edge noise reduction method based on the concept of active blowing air. A long slot is opened from the flap's lower surface to the tip surface to induce a secondary jet flow, which is driven by the local pressure difference between the flap's lower surface and the tip surface. The unsteady flow field around the flap side-edge was computed by the lattice Boltzmann solver PowerFLOW, and the far-field noise was predicted by the FW-H equation. It is demonstrated that the dominant features of the flap side-edge flow are the double vortex structures, and the new passive blowing air reduction method can achieve about 3.3 dB noise reduction. Moreover, the underlying noise reduction mechanism has been analyzed and revealed. It is shown that the secondary jet flow from the long slot on the flap side-edge would dissipate the flap side-edge vortex and displace the flap side-edge vortical structure away from the flap surface, thus resulting in a decrease in the pressure fluctuations on the flap side-edge surface. As a result, the flap side-edge noise was reduced. In contrast to the current active air blowing technique, the newly proposed blowing air technique is passive and quite simple and does not require an extra air source or control system. This novel flap side-edge noise reduction technology provides a new flow control strategy and noise reduction methodology and can be further optimized. [ABSTRACT FROM AUTHOR]

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been widely used in the quantitative analysis of drugs. The ubiquitous concomitant drug scenario in the clinic has spawned a large number of co-analyses based on this technique. However, signal suppression caused by concomitant drugs during electrospray ionization may affect the quantification accuracy of analytes, which has not received enough attention. In this study, metformin (MET) and glyburide (GLY) were co-eluted by the conventional optimization of chromatographic conditions to illustrate the effect of signal suppression caused by the combined drugs on the quantitative analysis. The response of MET was not affected by GLY over the investigated concentration range. However, the GLY signal could be suppressed by about 30% in the presence of MET, affecting its pharmacokinetic analysis in simulated samples. As an attempt to solve the suppression of GLY by co-eluting MET, dilution can alleviate the suppression. However, this method still has limitations due to the sacrifice of sensitivity. The stable isotope-labeled internal standard could play a role in correction and improve the quantitative accuracy of GLY, which was further confirmed in the pharmacokinetic study of simulated samples. This study provided an example model to illustrate the possible effect of clinical drug combination on LC-MS/MS drug quantitative analysis and investigated the effective methods to solve this problem. [ABSTRACT FROM AUTHOR]

Electronic cigarettes (e-cigarettes) have attracted much attention as a new substitute for conventional cigarettes. E-cigarettes are first exposed to the respiratory system after inhalation, and studies on the toxicity mechanisms of e-cigarettes have been reported. Current research shows that e-cigarette exposure may have potentially harmful effects on cells, animals, and humans, while the safety evaluation of the long-term effects of e-cigarette use is still unknown. Similar but not identical to conventional cigarettes, the toxicity mechanisms of e-cigarettes are mainly manifested in oxidative stress, inflammatory responses, and DNA damage. This review will summarize the toxicity mechanisms and signal pathways of conventional cigarettes and e-cigarettes concerning the respiratory system, which could give researchers a better understanding and direction on the effects of e-cigarettes on our health. [ABSTRACT FROM AUTHOR]

Autophagy is a highly- evolutionarily-conserved catabolic pathway activated by various cellular stresses. Recently, non-canonical autophagy (NCA), which does not require all of the ATG proteins to form autophagosome or autophagosome-like structures, has been found in various conditions. Moreover, mounting evidence has indicated that non-canonical LC3 lipidation (NCLL) may reflect NCA. We and others have reported that niclosamide (Nic), an anti-helminthic drug approved by the Food and Drug Administration, could induce canonical autophagy via a feedback downregulation of mTOR complex 1. In this study, we found that Nic could also induce NCLL, which is independent of the ULK1 complex and Beclin 1 complex, but dependent on ubiquitin-like conjugation systems. Although bafilomycin A1 and concanamycin A, two known V-ATPase inhibitors, significantly inhibited Nic-induced NCLL, Nic-induced NCLL was demonstrated to be independent of V-ATPase. In addition, the Golgi complex and vimentin were involved in Nic-induced NCLL, which might be a platform or membrane source for Nic-induced LC3-positive structures. These results would be helpful to broaden our understanding of the working mechanisms of Nic and evaluate its pharmacological activities in diseases. [ABSTRACT FROM AUTHOR]