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The renin–angiotensin system (RAS) and hypoxia have a complex interaction: RAS is activated under hypoxia and activated RAS aggravates hypoxia in reverse. Renin is an aspartyl protease that catalyzes the first step of RAS and tightly regulates RAS activation. Here, we outline kidney renin expression and release under hypoxia and discuss the putative mechanisms involved. It is important that renin generally increases in response to acute hypoxemic hypoxia and intermittent hypoxemic hypoxia, but not under chronic hypoxemic hypoxia. The increase in renin activity can also be observed in anemic hypoxia and carbon monoxide-induced histotoxic hypoxia. The increased renin is contributed to by juxtaglomerular cells and the recruitment of renin lineage cells. Potential mechanisms regulating hypoxic renin expression involve hypoxia-inducible factor signaling, natriuretic peptides, nitric oxide, and Notch signaling-induced renin transcription. [ABSTRACT FROM AUTHOR]

To utilize its rich aromatics, lignin, a high-volume waste and environmental hazard, was depolymerized in supercritical ethanol over various zeolites types with different acidity and pore structures. Targeting at high yield/selectivity of aromatics such as phenols, microporous Beta, Y, and ZSM-5 zeolites were first examined in lignin ethanolysis, followed by zeolites with similar micropore size but different acidity. Further comparisons were made between zeolites with fin-like and worm-like mesoporous structures and their microporous counterparts. Despite depolymerization complexity and diversified ethanolysis products, strong acidity was found effective to cleave both C–O–C and C–C linkages of lignin while mild acidity works mainly in ether bond breakdown. However, when diffusion of gigantic molecules is severe, pore size, particularly mesopores, becomes more decisive on phenol selectivity. These findings provide important guidelines on future selection and design of zeolites with appropriate acidity and pore structure to promote lignin ethanolysis or other hydrocarbon cracking processes. [ABSTRACT FROM AUTHOR]