1. Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening
- Author
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Tomokazu Konishi, Monira Pervin, Keiko Unno, Yoriyuki Nakamura, and Kyoko Taguchi
- Subjects
Male ,medicine.medical_specialty ,Aging ,Memory, Long-Term ,immediate-early gene ,Longevity ,EGR1 ,Pharmaceutical Science ,Hippocampus ,Biology ,Article ,Catechin ,Analytical Chemistry ,lcsh:QD241-441 ,03 medical and health sciences ,Mice ,0302 clinical medicine ,lcsh:Organic chemistry ,Internal medicine ,Drug Discovery ,Gene expression ,medicine ,green tea catechin ,Animals ,Learning ,Cognitive Dysfunction ,Physical and Theoretical Chemistry ,Cognitive decline ,Genes, Immediate-Early ,cognitive function ,030304 developmental biology ,0303 health sciences ,Oncogene ,Tea ,Organic Chemistry ,SAMP10 ,Up-Regulation ,Endocrinology ,Nuclear receptor ,Chemistry (miscellaneous) ,CYR61 ,Molecular Medicine ,Transcriptome ,Immediate early gene ,030217 neurology & neurosurgery ,lifespan - Abstract
Senescence-accelerated mouse prone 10 (SAMP10) mice, after ingesting green tea catechins (GT-catechin, 60 mg/kg), were found to have suppressed aging-related decline in brain function. The dose dependence of brain function on GT-catechin indicated that intake of 1 mg/kg or more suppressed cognitive decline and a shortened lifespan. Mice that ingested 1 mg/kg GT-catechin had the longest median survival, but the dose was less effective at suppressing cognitive decline. The optimal dose for improving memory acquisition was 60 mg/kg, and memory retention was higher in mice that ingested 30 mg/kg or more. To elucidate the mechanism by which cognitive decline is suppressed by GT-catechin, changes in gene expression in the hippocampus of SAMP10 mice one month after ingesting GT-catechin were analyzed. The results show that the expression of immediate-early genes such as nuclear receptor subfamily 4 (Nr4a), FBJ osteosarcoma oncogene (Fos), early growth response 1 (Egr1), neuronal PAS domain protein 4 (Npas4), and cysteine-rich protein 61 (Cyr61) was significantly increased. These results suggest that GT-catechin suppresses age-related cognitive decline via increased expression of immediate-early genes that are involved in long-term changes in plasticity of synapses and neuronal circuits.
- Published
- 2020