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Toll-like receptors (TLRs) are among the main components of the innate immune system. They can detect conserved structures in microorganisms and molecules associated with stress and cellular damage. TLRs are expressed in resident immune cells and both neurons and glial cells of the nervous system. Increasing evidence is emerging on the participation of TLRs not only in the immune response but also in processes of the nervous system, such as neurogenesis and cognition. Below, we present a review of the literature that evaluates the expression and role of TLRs in processes such as neurodevelopment, behavior, cognition, infection, neuroinflammation, and neurodegeneration. [ABSTRACT FROM AUTHOR]

In recent years, girls and young women have become particularly visible as leaders of activist campaigns and social movements. Drawing on data collected from an ACLU summer program for youth activists and advocates, this study explores the costs and benefits cisgender girls incur as a result of their activism. The findings reveal that although girls report more benefits than costs overall from their activism, the costs are correlated with the number of marginalized identities they hold. Queer Black girls report the greatest overall costs from their activism, and queer Multiracial girls report the highest rates of burnout. Queer White girls report significantly greater overall costs and problems as a result of their activism than heterosexual White girls, more burnout than heterosexual Black girls, and more empowerment than heterosexual Latinas. Informed by intersectionality and the PVEST framework, implications for supporting the sociopolitical action of girls with different social locations are discussed. [ABSTRACT FROM AUTHOR]