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In this study, we aimed to enhance the catalytic activity of perovskite catalysts and elucidate their catalytic behavior in the oxidative coupling of methane (OCM), using alkali-added LaAlO3 perovskite catalysts. We prepared LaAlO3-XY (X = Li, Na, K, Y = mol %) catalysts and applied them to the OCM reaction. The results showed that the alkali-added catalysts' activities were promoted compared to the LaAlO3 catalyst. In this reaction, ethane was first synthesized through the dimerization of methyl radicals, which were produced from the reaction of methane and oxygen vacancy in the perovskite catalysts. The high ethylene selectivity of the alkali-added catalysts originated from their abundance of electrophilic lattice oxygen species, facilitating the selective formation of C2 hydrocarbons from ethane. The high COx (carbon monoxide and carbon dioxide) selectivity of the LaAlO3 catalyst originated from its abundance of nucleophilic lattice oxygen species, favoring the selective production of COx from ethane. We concluded that electrophilic lattice oxygen species play a significant role in producing ethylene. We obtained that alkali-adding could be an effective method for improving the catalytic activity of perovskite catalysts in the OCM reaction. [ABSTRACT FROM AUTHOR]

: Recently, reconfigurable intelligent surfaces (RISs) have received much interest from both academia and industry due to their flexibility and cost-effectiveness in adjusting the phase and amplitude of wireless signals with low-cost passive reflecting elements. In particular, many RIS-aided techniques have been proposed to improve both data rate and energy efficiency for 6G wireless communication systems. In this paper, we propose a novel RIS-based channel randomization (RCR) technique for improving physical-layer security (PLS) for a time-division duplex (TDD) downlink cellular wire-tap network which consists of a single base station (BS) with multiple antennas, multiple legitimate pieces of user equipment (UE), multiple eavesdroppers (EVEs), and multiple RISs. We assume that only a line-of-sight (LOS) channel exists among the BS, the RISs, and the UE due to propagation characteristics of tera-hertz (THz) spectrum bands that may be used in 6G wireless communication systems. In the proposed technique, each RIS first pseudo-randomly generates multiple reflection matrices and utilizes them for both pilot signal duration (PSD) in uplink and data transmission duration (DTD) in downlink. Then, the BS estimates wireless channels of UE with reflection matrices of all RISs and selects the UE that has the best secrecy rate for each reflection matrix generated. It is shown herein that the proposed technique outperforms the conventional techniques in terms of achievable secrecy rates. [ABSTRACT FROM AUTHOR]

The degradation of low concentrations of acetaldehyde while using a non-thermal plasma (NTP)/catalyst hybrid reactor system was investigated while using humidified air at ambient temperature. A series of highly active manganese-impregnated natural zeolite (Mn/NZ) catalysts were synthesized by the incipient wetness method using sonication. The Mn/NZ catalysts were analyzed by Brunauer-Emmett-Teller surface area measurements and X-ray photoelectron spectroscopy. The Mn/NZ catalyst located at the downstream of a dc corona was used for the decomposition of ozone and acetaldehyde. The decomposition efficiency of ozone and acetaldehyde was increased significantly using the Mn/NZ catalyst with NTP. Among the various types of Mn/NZ catalysts with different Mn contents, the 10 wt.% Mn/NZ catalyst under the NTP resulted the highest ozone and acetaldehyde removal efficiency, almost 100% within 5 min. Moreover, this high efficiency was maintained for 15 h. The main reason for the high catalytic activity and stability was attributed to the high dispersion of Mn on the NZ made by the appropriate impregnation method using sonication. This system is expected to be efficient to decompose a wide range of volatile organic compounds with low concentrations. [ABSTRACT FROM AUTHOR]

When multiple mobile sensors and actuators share a common wireless mesh backbone network of defence systems, the channel allocation mechanism must guarantee the heterogeneous link requirements under conditions of uncertainty. In this paper, a robust channel allocation mechanism is proposed by exploiting partially overlapped channels for directional multi-channel wireless mesh networks. The approach relies on a chance-constrained optimization problem, in which the objective is to minimize the spectrum usage of the network, and the constraints are the signal-to-interference-plus-noise ratio requirements of links with uncertainty. We convert the proposed integer non-linear optimization problem into a mixed-integer convex problem by using efficient transition and approximation. The optimal channel allocation is obtained by solving the proposed optimization problem which adapts to the heterogeneous link and robustness requirements. The simulation results show that the proposed method ensures the heterogeneous link requirements under uncertain conditions while minimizing the spectrum usage of the network. [ABSTRACT FROM AUTHOR]

Practical synthesis and biological activities of 4-hydroxy-3-methoxy-2-propene derivatives are described. The novel chalcone derivatives were prepared by acid catalysed one-step condensation of 1,3- or 1,4-diacetylbenzene and 1,3,5-triacetylbenzene with 4-hydroxy-3-methoxybenzaldehyde. They were then evaluated for free radical scavenging activity, suppression of lipopolysaccharides (LPS)-induced NO generation, and anti-excitotoxicity in vitro. It was found that all compounds showed good effects for 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, LPS-induced NO generation, and anti-neurotoxicity. Compounds 6 and 7 were potent suppressor of NO generation with the concentration range 10 μM and especially compound 8 showed very potent anti-inflammatory activity with 1 μM. In addition, the di- and tri-acetylbenzyl derivatives 6, 7, and 8 showed enhanced anti-neurotoxicity activity in cultured cortical neurons. Molecular modelling studies to investigate the chemical structural characteristics required for the enhanced biological activities interestingly revealed that compound 8 has the smallest highest occupied molecular orbital-lowest energy unoccupied molecular orbital (HOMO-LUMO) gap, which signifies easy electron and radical transfer between HOMO and LUMO in model studies. [ABSTRACT FROM AUTHOR]

The catalytic activities of acid catalysts for the acetylation of triethyl citrate with acetic anhydride in the preparation of acetyl triethyl citrate were evaluated. Microporous zeolites such as HZSM-5 and HY zeolites catalysts were introduced as heterogeneous acid catalysts. HZSM-5 zeolite catalysts showed a high conversion of triethyl citrate and excellent selectivity of acetyl triethyl citrate. The catalytic activities of HZSM-5 zeolites were superior to those of the HY zeolites. In particular, the selectivity of acetyl triethyl citrate on HZSM-5 zeolites exceeded 95%. The moderate acid strength of HZSM-5 (Si/Al = 75) zeolite led to the highest catalytic activities among the HZSM-5 zeolite catalysts, which have various acid strengths. [ABSTRACT FROM AUTHOR]

We previously showed that barley sprout extract (BSE) prevents chronic alcohol intake-induced liver injury in mice. BSE notably inhibited glutathione (GSH) depletion and increased inflammatory responses, revealing its mechanism of preventing alcohol-induced liver injury. In the present study we investigated whether the antioxidant effect of BSE involves enhancing nuclear factor-erythroid 2 related factor 2 (Nrf2) activity and GSH synthesis to inhibit alcohol-induced oxidative liver injury. Mice fed alcohol for four weeks exhibited significantly increased oxidative stress, evidenced by increased malondialdehyde (MDA) level and 4-hydroxynonenal (4-HNE) immunostaining in the liver, whereas treatment with BSE (100 mg/kg) prevented these effects. Similarly, exposure to BSE (0.1-1 mg/mL) significantly reduced oxidative cell death induced by t-butyl hydroperoxide (t-BHP, 300 µM) and stabilized the mitochondrial membrane potential (D ). BSE dose-dependently increased the activity of Nrf2, a potential transcriptional regulator of antioxidant genes, in HepG2 cells. Therefore, increased expression of its target genes, heme oxygenase-1 (HO-1), NADPH quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase catalytic subunit (GCLC) was observed. Since GCLC is involved in the rate-limiting step of GSH synthesis, BSE increased the GSH level and decreased both cysteine dioxygenase (CDO) expression and taurine level. Because cysteine is a substrate for both taurine and GSH synthesis, a decrease in CDO expression would further contribute to increased cysteine availability for GSH synthesis. In conclusion, BSE protected the liver cells from oxidative stress by activating Nrf2 and increasing GSH synthesis. [ABSTRACT FROM AUTHOR]

We introduce a distributed protocol to achieve multiuser diversity in a multicell multiple-input multiple-output (MIMO) uplink network, referred to as a MIMO interfering multiple-access channel (IMAC). Assuming both no information exchange among base stations (BS) and local channel state information at the transmitters for the MIMO IMAC, we propose a joint beamforming and user scheduling protocol, and then show that the proposed protocol can achieve the optimal multiuser diversity gain, i.e., KMlog(SNRlog N), as long as the number of mobile stations (MSs) in a cell, N, scales faster than SNRKM-L/1-ε for a small constant ε > 0, where M, L, K, and SNR denote the number of receive antennas at each BS, the number of transmit antennas at each MS, the number of cells, and the signal-to-noise ratio, respectively. Our result indicates that multiuser diversity can be achieved in the presence of intra-cell and inter-cell interference even in a distributed fashion. As a result, vital information on how to design distributed algorithms in interference-limited cellular environments is provided. [ABSTRACT FROM AUTHOR]

Laser detection and ranging (LADAR) systems are commonly used to acquire real-time three-dimensional (3D) images using the time-of-flight of a short laser pulse. A static unitary detector (STUD)-based LADAR system is a simple method for obtaining real-time high-resolution 3D images. In this study, a switched 4-to-1 transimpedance combining amplifier (TCA) is implemented as a receiver front-end readout integrated circuit for the STUD-based LADAR system. The 4-to-1 TCA is fabricated using a standard 0.18 μm complementary metal-oxide-semiconductor (CMOS) technology, and it consists of four independent current buffers, a two-stage signal combiner, a balun, and an output buffer in one single integrated chip. In addition, there is a switch on each input current path to expand the region of interest with multiple photodetectors. The core of the TCA occupies an area of 92 μm × 68 μm, and the die size including I/O pads is 1000 μm × 840 μm. The power consumption of the fabricated chip is 17.8 mW for a supplied voltage of 1.8 V and a transimpedance gain of 67.5 dBΩ. The simulated bandwidth is 353 MHz in the presence of a 1 pF photodiode parasitic capacitance for each photosensitive cell. [ABSTRACT FROM AUTHOR]

The catalytic properties of microporous zeolite catalysts were evaluated in the synthesis of decyl glucoside from glucose with 1-decanol by direct glucosidation. The effects of the acidic properties and pore structure of the zeolite catalysts on the glucose conversions and decyl glucoside yields were investigated. The conversions of glucose on the H+ ion-exchanged FAU, MFI, and BEA zeolite catalysts were above 70%. The conversion increased with decreasing acid strength of the catalysts. The highest conversion and yield of decyl glucoside were exhibited on the H-FAU(3) zeolite catalyst. The catalytic activities were enhanced with increasing amounts of acid sites. The selectivity of decyl glucopyranoside increased with decreasing Si/Al values for the same zeolite catalysts. The pore structure of H-FAU zeolite would allow sufficient spatial restriction to produce decyl glucopyranoside through the isomerization of decyl glucofuranoside into decyl glucopyranoside in its extensive pore channels. The selectivities of the decyl glucoside isomers relied significantly on the restricted transition state to the primary products due to their pore topologies. [ABSTRACT FROM AUTHOR]

Maternal malnutrition influences the early development of foetal adaptive changes for survival. We explored the effects of maternal undernutrition during gestation and lactation on hepatic growth and function. Sprague-Dawley rats were fed a normal or a food-restricted (FR) diet during gestation and/or lactation. We performed analyses of covariance (adjusting for the liver weight/body weight ratio) to compare hepatic growth and lipid metabolism among the offspring. Maternal FR during gestation triggered the development of wide spaces between hepatic cells and increased the expression of mammalian target of rapamycin (mTOR) in three-week-old male offspring compared with controls (both p < 0.05). Offspring nursed by FR dams exhibited wider spaces between hepatic cells and a lower liver weight/body weight ratio than control offspring, and increased mTOR expression (p < 0.05). Interestingly, the significant decrease in expression of lipogenic-related genes was dependent on carbohydrate-responsive element-binding protein, despite the increased expression of sterol regulatory element-binding protein 1 (SREBP1) (p < 0.05). This study demonstrated increased expression of key metabolic regulators (mTOR and SREBP1), alterations in lipid metabolism, and deficits in hepatic growth in the offspring of FR-treated dams. [ABSTRACT FROM AUTHOR]

Improving energy efficiency (EE) of mobile communication systems (MCSs) has been considered a key aim in recent years, and has been the subject of intense research interest. One of the simplest yet most powerful ways to increase the EE is to turn off redundant communication entities whose operation does not greatly affect the overall performance of the MCS. In this paper, we propose a novel on-off power control scheme for femto-cell base stations (FBSs) considering cooperative transmission in which multiple FBSs collaborate on the same data transmission. In the proposed scheme, the operation of the redundant FBSs is halted in an adaptive manner. For the proper determination of redundant FBSs with low computational complexity, we propose using the level of contribution (LOC), which specifies the importance of a given FBS in the cooperative transmission. Redundant FBSs are chosen based on their LOC value, and these FBSs are turned off in order to reduce the power consumption of MCSs while minimizing the degradation of the overall throughput of cooperative transmissions. The performance of the proposed scheme is verified through extensive simulations, which shows that near-optimal performance can be achieved without excessive computations. [ABSTRACT FROM AUTHOR]

Schwann cells (SCs), which produce neurotropic factors and adhesive molecules, have been reported previously to contribute to structural support and guidance during axonal regeneration; therefore, they are potentially a crucial target in the restoration of injured nervous tissues. Autologous SC transplantation has been performed and has shown promising clinical results for treating nerve injuries and donor site morbidity, and insufficient production of the cells have been considered as a major issue. Here, we performed differentiation of tonsil-derived mesenchymal stem cells (T-MSCs) into SC-like cells (T-MSC-SCs), to evaluate T-MSC-SCs as an alternative to SCs. Using SC markers such as CAD19, GFAP, MBP, NGFR, S100B, and KROX20 during quantitative real-time PCR we detected the upregulation of NGFR, S100B, and KROX20 and the downregulation of CAD19 and MBP at the fully differentiated stage. Furthermore, we found myelination of axons when differentiated SCs were cocultured with mouse dorsal root ganglion neurons. The application of T-MSC-SCs to a mouse model of sciatic nerve injury produced marked improvements in gait and promoted regeneration of damaged nerves. Thus, the transplantation of human T-MSCs might be suitable for assisting in peripheral nerve regeneration. [ABSTRACT FROM AUTHOR]

It has been reported that barley leaves possess beneficial properties such as antioxidant, hypolipidemic, antidepressant, and antidiabetic. Interestingly, barley sprouts contain a high content of saponarin, which showed both anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of barley sprouts on alcohol-induced liver injury mediated by inflammation and oxidative stress. Raw barley sprouts were extracted, and quantitative and qualitative analyses of its components were performed. The mice were fed a liquid alcohol diet with or without barley sprouts for four weeks. Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were used to study the effect of barley sprouts on inflammation. Alcohol intake for four weeks caused liver injury, evidenced by an increase in serum alanine aminotransferase and aspartate aminotransferase activities and tumor necrosis factor (TNF)-α levels. The accumulation of lipid in the liver was also significantly induced, whereas the glutathione (GSH) level was reduced. Moreover, the inflammation-related gene expression was dramatically increased. All these alcohol-induced changes were effectively prevented by barley sprouts treatment. In particular, pretreatment with barley sprouts significantly blocked inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in LPS-stimulated RAW 264.7. This study suggests that the protective effect of barley sprouts against alcohol-induced liver injury is potentially attributable to its inhibition of the inflammatory response induced by alcohol. [ABSTRACT FROM AUTHOR]

This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases. [ABSTRACT FROM AUTHOR]

The hydrodynamics of low-lying riverine floodplains and wetlands play a critical role in hydrology and ecosystem processes. Because small topographic features affect floodplain storage and flow velocity, a hydrodynamic model setup of these regions imposes more stringent requirements on the input Digital Elevation Model (DEM) compared to upland regions with comparatively high slopes. This current study provides a systematic approach to evaluate the required relative vertical accuracy and spatial resolution of current and future satellite-based altimeters within the context of DEM requirements for 2-D floodplain hydrodynamic models. A case study is presented for the Atchafalaya Basin with a model domain of 1190 km2. The approach analyzes the sensitivity of modeled floodplain water elevation and velocity to typical satellite-based DEM grid-box scale and vertical error, using a previously calibrated version of the physically-based flood inundation model (LISFLOOD-ACC). Results indicate a trade-off relationship between DEM relative vertical error and grid-box size. Higher resolution models are the most sensitive to vertical accuracy, but the impact diminishes at coarser resolutions because of spatial averaging. The results provide guidance to engineers and scientists when defining the observation scales of future altimetry missions such as the Surface Water and Ocean Topography (SWOT) mission from the perspective of numerical modeling requirements for large floodplains of O[103] km2 and greater. [ABSTRACT FROM AUTHOR]

Synthetic Aperture Radar (SAR) has been successfully used to map wetland's inundation extents and types of vegetation based on the fact that the SAR backscatter signal from the wetland is mainly controlled by the wetland vegetation type and water level changes. This study describes the relation between L-band PALSAR σ0 and seasonal water level changes obtained from Envisat altimetry over the island of Île Mbamou in the Congo Basin where two distinctly different vegetation types are found. We found positive correlations between σ0 and water level changes over the forested southern Île Mbamou whereas both positive and negative correlations were observed over the non-forested northern Île Mbamou depending on the amount of water level increase. Based on the analysis of σ0 sensitivity, we found that denser vegetation canopy leads to less sensitive σ0 variation with respect to the water level changes regardless of forested or non-forested canopy. Furthermore, we attempted to estimate water level changes which were then compared with the Envisat altimetry and InSAR results. Our results demonstrated a potential to generate two-dimensional maps of water level changes over the wetlands, and thus may have substantial synergy with the planned Surface Water and Ocean Topography (SWOT) mission. [ABSTRACT FROM AUTHOR]

Simple synthesis of modafinil derivatives and their biological activity are described. The key synthetic strategies involve substitution and coupling reactions. We determined the anti-inflammatory effects of modafinil derivatives in cultured BV2 cells by measuring the inhibition of nitrite production and expression of iNOS and COX-2 after LPS stimulation. It was found that for sulfide analogues introduction of aliphatic groups on the amide part (compounds 11a-d) resulted in lower anti-inflammatory activity compared with cyclic or aromatic moieties (compounds 11e-k). However, for the sulfoxide analogues, introduction of aliphatic moieties (compounds 12a-d) showed higher anti-inflammatory activity than cyclic or aromatic fragments (compounds 12e-k) in BV-2 microglia cells. [ABSTRACT FROM AUTHOR]

The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction of the O-alkylated ketone 13 afforded good yield of precusor alcohol 5. Final coupling of alcohol 5 with 4-hydroxycoumarin yielded flocoumafen (1). Separation and structure determination of cis- and trans-flocoumafen through 2D NMR analyses-assisted computer simulation techniques for the evaluation of anticoagulant activities are reported for the first time. This method is useful for generating the core tetralone skeleton of 4-hydroxycoumarin derivatives and provides a generalized access to various warfarin type anticoagulants. [ABSTRACT FROM AUTHOR]

A simple and efficient seven steps synthesis of brodifacoum and difethialone from phenylacetyl chloride is described. The key synthetic strategies involve Friedel-Crafts acylation, intramolecular ring cyclization and condensation reaction in the presence of Brønsted-Lowry acids. It was found that brodifacoum showed favorable inhibiting activities on LPS-stimulated nitrite production in BV-2 microglia cells. Brodifacoum exhibited superior anti-inflammatory effects than difethialone. We expect that an efficient linear synthesis of 4-hydroxycoumarin derivatives and key fragments that are useful agents for the modulation of inflammation as well as inhibition of coagulation will be of practical use. [ABSTRACT FROM AUTHOR]

Simple synthesis and biological activities of modafinil derivatives are described. The key reactions include condensation of acid and propargyl alcohol, subsequent 1,3-dipolar cycloaddition reaction of alkynes and (3-azido-propyl)cyclohexane or (4-azidobutyl) benzene in the presence of sodium ascorbate and CuSO4·5H2O in excellent yield. They were then evaluated for the suppression of LPS-induced NO generation in vitro. It was found that all compounds showed moderate effects for suppression of LPS-induced NO generation. [ABSTRACT FROM AUTHOR]

The function and the role phytoceramide (PCER) and phytosphingosine (PSO) in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuroprotective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS) showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o.) recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer's disease. [ABSTRACT FROM AUTHOR]

The main purpose of this review is to summarize recent chemical syntheses and structural modifications of 4-hydroxycoumarin and its derivatives, of interest due to their characteristic conjugated molecular architecture and biological activities. [ABSTRACT FROM AUTHOR]