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Background: Previous studies have associated slowed ventricular conduction with the arrhythmogenesis mediated by the gap junction and sodium channel inhibitor heptanol in mouse hearts. However, they did not study the propagation patterns that might contribute to the arrhythmic substrate. This study used a multi-electrode array mapping technique to further investigate different conduction abnormalities in Langendorff-perfused mouse hearts exposed to 0.1 or 2 mM heptanol. Methods: Recordings were made from the left ventricular epicardium using multi-electrode arrays in spontaneously beating hearts during right ventricular 8 Hz pacing or S1S2 pacing. Results: In spontaneously beating hearts, heptanol at 0.1 and 2 mM significantly reduced the heart rate from 314 ± 25 to 189 ± 24 and 157 ± 7 bpm, respectively (ANOVA, p < 0.05 and p < 0.001). During regular 8 Hz pacing, the mean LATs were increased by 0.1 and 2 mM heptanol from 7.1 ± 2.2 ms to 19.9 ± 5.0 ms (p < 0.05) and 18.4 ± 5.7 ms (p < 0.05). The standard deviation of the mean LATs was increased from 2.5 ± 0.8 ms to 10.3 ± 4.0 ms and 8.0 ± 2.5 ms (p < 0.05), and the median of phase differences was increased from 1.7 ± 1.1 ms to 13.9 ± 7.8 ms and 12.1 ± 5.0 ms by 0.1 and 2 mM heptanol (p < 0.05). P5 took a value of 0.2 ± 0.1 ms and was not significantly altered by heptanol at 0.1 or 2 mM (1.1 ± 0.9 ms and 0.9 ± 0.5 ms, p > 0.05). P50 was increased from 7.3 ± 2.7 ms to 24.0 ± 12.0 ms by 0.1 mM heptanol and then to 22.5 ± 7.5 ms by 2 mM heptanol (p < 0.05). P95 was increased from 1.7 ± 1.1 ms to 13.9 ± 7.8 ms by 0.1 mM heptanol and to 12.1 ± 5.0 ms by 2 mM heptanol (p < 0.05). These changes led to increases in the absolute inhomogeneity in conduction (P5–95) from 7.1 ± 2.6 ms to 31.4 ± 11.3 ms, 2 mM: 21.6 ± 7.2 ms, respectively (p < 0.05). The inhomogeneity index (P5–95/P50) was significantly reduced from 3.7 ± 1.2 to 3.1 ± 0.8 by 0.1 mM and then to 3.3 ± 0.9 by 2 mM heptanol (p < 0.05). Conclusion: Increased activation latencies, reduced CVs, and the increased inhomogeneity index of conduction were associated with both spontaneous and induced ventricular arrhythmias. [ABSTRACT FROM AUTHOR]

This paper is devoted to the study of the quadruple Roman domination in trees, and it is a contribution to the Special Issue "Theoretical computer science and discrete mathematics" of Symmetry. For any positive integer k, a [ k ] -Roman dominating function ( [ k ] -RDF) of a simple graph G is a function from the vertex set V of G to the set { 0 , 1 , 2 , ... , k + 1 } if for any vertex u ∈ V with f (u) < k , ∑ x ∈ N (u) ∪ { u } f (x) ≥ | { x ∈ N (u) : f (x) ≥ 1 } | + k , where N (u) is the open neighborhood of u. The weight of a [ k ] -RDF is the value Σ v ∈ V f (v) . The minimum weight of a [ k ] -RDF is called the [ k ] -Roman domination number γ [ k R ] (G) of G. In this paper, we establish sharp upper and lower bounds on γ [ 4 R ] (T) for nontrivial trees T and characterize extremal trees. [ABSTRACT FROM AUTHOR]

A paired-dominating set of a graph G without isolated vertices is a dominating set of vertices whose induced subgraph has perfect matching. The minimum cardinality of a paired-dominating set of G is called the paired-domination number γpr(G) of G. The paired-domination subdivision number sdγpr(G) of G is the minimum number of edges that must be subdivided (each edge in G can be subdivided at most once) in order to increase the paired-domination number. Here, we show that, for each tree T ≠ P5 of order n ≥ 3 and each edge e ∉ E(T), sdγpr(T) + sdγpr(T + e) ≤ n + 2. [ABSTRACT FROM AUTHOR]

In order to increase the paired-domination number of a graph G, the minimum number of edges that must be subdivided (where each edge in G can be subdivided no more than once) is called the paired-domination subdivision number sd γ p r (G) of G. It is well known that sd γ p r (G + e) can be smaller or larger than sd γ p r (G) for some edge e ∉ E (G). In this note, we show that, if G is an isolated-free graph different from m K 2 , then, for every edge e ∉ E (G) , sd γ p r (G + e) ≤ sd γ p r (G) + 2 Δ (G) . [ABSTRACT FROM AUTHOR]