7 results on '"Ha, Nguyen Thi Thu"'
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2. Theoretical Analysis of Superior Photodegradation of Methylene Blue by Cerium Oxide/Reduced Graphene Oxide vs. Graphene.
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Hao, Nguyen Hoang, Lan, Phung Thi, Ha, Nguyen Ngoc, Cam, Le Minh, and Ha, Nguyen Thi Thu
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GRAPHENE oxide ,MOLECULAR orbitals ,DENSITY functional theory ,ACID catalysts ,PHOTODEGRADATION - Abstract
Density functional theory and a semi-empirical quantum chemical approach were used to evaluate the photocatalytic efficiency of ceria (CeO
2 ) combined with reduced graphene oxide (rGO) and graphene (GP) for degrading methylene blue (MB). Two main aspects were examined: the adsorption ability of rGO and GP for MB, and the separation of photogenerated electrons and holes in CeO2 /rGO and CeO2 /GP. Our results, based on calculations of the adsorption energy, population analysis, bond strength index, and reduced density gradient, show favorable energetics for MB adsorption on both rGO and GP surfaces. The process is driven by weak, non-covalent interactions, with rGO showing better MB adsorption. A detailed analysis involving parameters like fractional occupation density, the centroid distance between molecular orbitals, and the Lewis acid index of the catalysts highlights the effective charge separation in CeO2 /rGO compared to CeO2 /GP. These findings are crucial for understanding photocatalytic degradation mechanisms of organic dyes and developing efficient photocatalysts. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Antimicrobial, Cytotoxic, and α -Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies.
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Phuong, Diep Thi Lan, Van Phuong, Nguyen, Le Tuan, Nguyen, Cong, Nguyen Thanh, Hang, Nguyen Thu, Thanh, Le Nguyen, Hue, Vu Thi, Vuong, Nguyen Quoc, Ha, Nguyen Thi Thu, Popova, Milena, Trusheva, Boryana, and Bankova, Vassya
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MOLECULAR docking ,PROPOLIS ,ETHANOL ,XANTHONE ,STINGLESS bees ,URSOLIC acid ,BINDING energy - Abstract
The chemical investigation of Homotrigona apicalis propolis collected in Binh Dinh province, Vietnam, led to the isolation of nine compounds, including four sesquiterpenes: spathulenol (1), 1αH,5βH-aromandendrane-4β,10α-diol (2), 1β,6α-dihydroxy-4(15)-eudesmene (3), and 1βH,5βH-aromandendrane-4α,10β-diol (4); three triterpenes: acetyl oleanolic acid (5), 3α-hydroxytirucalla-8,24-dien-21-oic acid (6), and ursolic acid (7); and two xanthones: cochinchinone A (8) and α-mangostin (9). Sesquiterpens 1–4 and triterpene 6 were isolated for the first time from stingless bee propolis. Plants in the Cratoxylum and Aglaia genus were suggested as resin sources of the propolis sample. In the antibacterial activity evaluation, the EtOH extract only showed moderate activity on S. aureus, while the isolated compounds 7–9 showed good antibacterial activity, with IC
50 values of 0.56 to 17.33 µg/mL. The EtOH extract displayed selective cytotoxicity against the A-549 cancer cell line, with IC50 values of 22.82 ± 0.86 µg/mL, and the xanthones 8 and 9 exhibited good activity against the KB, HepG-2, and A-549 cancer cell lines, with IC50 values ranging from 7.55 ± 0.25 µg/mL to 29.27 ± 2.07 µg/mL. The cytotoxic effects of xanthones 8 and 9 were determined by the inhibition of the EGFR and HER2 pathways using a molecular docking study. Compounds 8 and 9 displayed strong binding affinity with EFGR and HER2, with values of −9.3 to −9.9 kcal/mol. Compounds 5, 8, and 9 showed potential α-glucosidase inhibitory activities, which were further confirmed by computational studies. The binding energies of compounds 5, 8, and 9 were lower than that of arcabose. [ABSTRACT FROM AUTHOR]- Published
- 2023
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4. Stepwise Reduction of Mycophenolate Mofetil with Conversion to Everolimus for the Treatment of Active BKV in Kidney Transplant Recipients: A Single-Center Experience in Vietnam.
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Kien, Truong Quy, Kien, Nguyen Xuan, Thang, Le Viet, Nghia, Phan Ba, Van, Diem Thi, Duc, Nguyen Van, Ha, Do Manh, Dung, Nguyen Thi Thuy, Ha, Nguyen Thi Thu, Loan, Vu Thi, Vinh, Hoang Trung, Manh, Bui Van, Su, Hoang Xuan, Tien, Tran Viet, Rostaing, Lionel, and Toan, Pham Quoc
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BK virus ,KIDNEY transplantation ,MYCOPHENOLIC acid ,EVEROLIMUS ,VIRAL load ,KIDNEY physiology - Abstract
Background: No specific antiviral drug can effectively treat BKV reactivation after kidney transplantation. Thus, we evaluated stepwise-reduced immunosuppression to treat BKV reactivation. Methods: 341 kidney-transplant recipients were monitored for BKV infection (BKV-viremia, BKV-viruria). Positive samples with a significant virus load were nested PCR-genotyped in the VP1 region. In 97/211 patients presenting BKV viremia ≥10
4 copies/mL and/or BKV viruria ≥107 copies/mL, or BKV-nephropathy immunosuppression (i.e., mycophenolate mofetil [MMF]) was reduced by 50%. If viral load did not decrease within 28 days, MMF dose was further reduced by 25%, although calcineurin-inhibitor (CNI) therapy remained unchanged. If BKV viral load did not decrease within another 28 days, MMF was withdrawn and replaced by everolimus combined with reduced CNIs. Results: Only 41/97 BKV (+) cases completed the 6-month follow-up. Among these, 29 (71%) were in the BKV-I group and 12 (29%) were in BKV-IV. BKV viruria and BKV viremia were significantly decreased from 9.32 to 6.09 log10 copies/mL, and from 3.59 to 2.45 log10 copies/mL (p < 0.001 and p = 0.024, respectively). 11/32 (34.4%) patients were cleared of BKV viremia; 2/32 (6.3%) patients were cleared of BKV in both serum and urine, and 9/9 (100%) only had BKV viruria but did not develop BKV viremia. eGFR remained stable. No patient with BKV-related nephropathy had graft loss. There was a significant inverse relationship between changes in eGFR and serum BKV load (r = −0.314, p = 0.04). Conclusions: This stepwise immunosuppressive strategy proved effective at reducing BKV viral load in kidney transplant recipients that had high BKV loads in serum and/or urine. Renal function remained stable without rejection. [ABSTRACT FROM AUTHOR]- Published
- 2022
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5. Genomic Mutations of BK Polyomavirus in Patients after Kidney Transplantation: A Cross-Sectional Study in Vietnam.
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Kien, Truong Quy, Toan, Pham Quoc, Nghia, Phan Ba, Van, Diem Thi, Duc, Nguyen Van, Ha, Do Manh, Dung, Nguyen Thi Thuy, Ha, Nguyen Thi Thu, Quyen, Le Thi Bao, Vinh, Hoang Trung, Manh, Bui Van, Su, Hoang Xuan, Tien, Tran Viet, Thang, Le Viet, and Rostaing, Lionel
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BK virus ,KIDNEY transplantation ,POLYOMAVIRUSES ,SINGLE nucleotide polymorphisms ,GENETIC mutation ,CROSS-sectional method - Abstract
Objectives: The purpose of this study was to identify the SNP sites and determine the BKV genotype circulating in kidney-transplant Vietnamese recipients based on the VP1 gene region. Methods: 344 samples were collected from post-kidney-transplant recipients at the 103 Vietnam Military Hospital to investigate the number of BKV infections. Positive samples with a sufficient virus concentration were analyzed by nested PCR in the VP1 region, sequencing detected genotyping and single-nucleotide polymorphism. Results: BKV infection was determined in 214 patients (62.2%), of whom 11 (5.1%) were diagnosed with BKV-associated nephropathy. Among the 90 BKV-I strains sequenced, 89 (98.88%) were strains of I/b-1 and 1 (1.12%) was strain I/b-2. The 60 BKV-IV strains had a greater diversity of subgroups, including 40% IV/a-1, 1.66% IV/a-2, 56.68% IV/c-1, and 1.16% IV/c-2. Additionally, of 11 cases diagnosed with BKVN, seven belonged to subgroup I/b-1 (63.6%) and four to subgroup IV/c-1 (36.4%). Moreover, 22 specific SNPs that were genotype I or IV were determined in this Vietnamese population. Specifically, at position 1745, for the Vietnamese BKV-IV strains, the SNP position (A→G) appeared in 57/60 samples (95%). This causes transformation of the amino acid N→S. This SNP site can enable detection of genotype IV in Vietnam. It represents a unique evolution pattern and mutation that has not been found in other international strains. Conclusion: The BKV-I genotype was more common than BKV-IV; however, mutations that occur on the VP1 typing region of BKV-IV strains were more frequent than in BKV-I strains. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Effective Band Ratio of Landsat 8 Images Based on VNIR-SWIR Reflectance Spectra of Topsoils for Soil Moisture Mapping in a Tropical Region.
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Ngo Thi, Dinh, Ha, Nguyen Thi Thu, Tran Dang, Quy, Koike, Katsuaki, and Mai Trong, Nhuan
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SOIL moisture , *REMOTE sensing , *REFLECTANCE , *TOPSOIL , *SOIL pollution - Abstract
Effective mapping and monitoring of soil moisture content (SMC) in space and time is an expected application of remote sensing for agricultural development and drought mitigation, particularly in the context of global climate change impact, given that agricultural drought is occurring more frequently and severely worldwide. This study aims to develop a regional algorithm for estimating SMC by using Landsat 8 (L8) imagery, based on analyses of the response of soil reflectance, by corresponding L8 bands with the change of SMC from dry to saturated states, in all 103 soil samples taken in the central region of Vietnam. The L8 spectral band ratio of the near-infrared band (NIR: 850–880 nm, band 5) versus the short-wave infrared 2 band (SWIR2: 2110 to 2290 nm, band 7) shows the strongest correlation to SMC by a logarithm function (R2 = 0.73 and the root mean square error, RMSE ~ 12%) demonstrating the high applicability of this band ratio for estimating SMC. The resultant maps of SMC estimated from the L8 images were acquired over the northern part of the Central Highlands of Vietnam in March 2015 and March 2016 showed an agreement with the pattern of severe droughts that occurred in the region. Further discussions on the relationship between the estimated SMC and the satellite-based retrieved drought index, the Normal Different Drought Index, from the L8 image acquired in March 2016, showed a strong correlation between these two variables within an area with less than 20% dense vegetation (R2 = 0.78 to 0.95), and co-confirms the bad effect of drought on almost all areas of the northern part of the Central Highlands of Vietnam. Directly estimating SMC from L8 imagery provides more information for irrigation management and better drought mitigation than by using the remotely sensed drought index. Further investigations on various soil types and optical sensors (i.e., Sentinel 2A, 2B) need to be carried out, to extend and promote the applicability of the prosed algorithm, towards better serving agricultural management and drought mitigation. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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7. Using Landsat-8 Images for Quantifying Suspended Sediment Concentration in Red River (Northern Vietnam).
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Pham, Quang Vinh, Ha, Nguyen Thi Thu, Pahlevan, Nima, Oanh, La Thi, Nguyen, Thanh Binh, and Nguyen, Ngoc Thang
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SUSPENDED sediments , *LANDSAT satellites , *RADIOMETRY , *WATERSHEDS - Abstract
Analyzing the trends in the spatial distribution of suspended sediment concentration (SSC) in riverine surface water enables better understanding of the hydromorphological properties of its watersheds and the associated processes. Thus, it is critical to identify an appropriate method to quantify spatio-temporal variability in SSC. This study aims to estimate SSC in a highly turbid river, i.e., the Red River in Northern Vietnam, using Landsat 8 (L8) images. To do so, in situ radiometric data together with SSC at 60 sites along the river were measured on two different dates during the dry and wet seasons. Analyses of the in situ data indicated strong correlations between SSC and the band-ratio of green and red channels, i.e., r-squared = 0.75 and a root mean square error of ~0.3 mg/L. Using a subsample of in situ radiometric data (n = 30) collected near-concurrently with one L8 image, four different atmospheric correction methods were evaluated. Although none of the methods provided reasonable water-leaving reflectance spectra (ρw), it was found that the band-ratio of the green-red ratio is less sensitive to uncertainties in the atmospheric correction for mapping SSC compared to individual bands. Therefore, due to its ease of access, standard L8 land surface reflectance products available via U.S. Geological Survey web portals were utilized. With the empirical relationship derived, we produced Landsat-derived SSC distribution maps for a few images collected in wet and dry seasons within the 2013–2017 period. Analyses of image products suggest that (a) the Thao River is the most significant source amongst the three major tributaries (Lo, Da and Thao rivers) providing suspended load to the Red River, and (b) the suspended load in the rainy season is nearly twice larger than that in the dry season, and it correlates highly with the runoff (correlation coefficient = 0.85). Although it is demonstrated that the atmospheric correction in tropical areas over these sediment-rich waters present major challenges in the retrievals of water-leaving reflectance spectra, the study signifies the utility of band-ratio techniques for quantifying SSC in highly turbid river waters. With Sentinel-2A/B data products combined with those of Landsat-8, it would be possible to capture temporal variability in major river systems in the near future. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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