1. Histone deacetylases in herpesvirus replication and virus-stimulated host defense.
- Author
-
Guise AJ, Budayeva HG, Diner BA, and Cristea IM
- Subjects
- Acetylation, Metabolome, Protein Processing, Post-Translational, Proteomics, Viral Proteins chemistry, Herpesviridae immunology, Herpesviridae physiology, Histone Deacetylases metabolism, Host-Pathogen Interactions, Viral Proteins metabolism, Virus Replication
- Abstract
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.
- Published
- 2013
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