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Stochastic differential equations (SDE) appropriately describe a variety of phenomena occurring in random environments, such as the growth dynamics of individual animals. Using appropriate weight transformations and a variant of the Ornstein–Uhlenbeck model, one obtains a general model for the evolution of cattle weight. The model parameters are α , the average transformed weight at maturity, β , a growth parameter, and σ , a measure of environmental fluctuations intensity. We briefly review our previous work on estimation and prediction issues for this model and some generalizations, considering fixed parameters. In order to incorporate individual characteristics of the animals, we now consider that the parameters α and β are Gaussian random variables varying from animal to animal, which results in SDE mixed models. We estimate parameters by maximum likelihood, but, since a closed-form expression for the likelihood function is usually not possible, we approximate it using our proposed delta approximation method. Using simulated data, we estimate the model parameters and compare them with existing methodologies, showing that the proposed method is a good alternative. It also overcomes the existing methodologies requirement of having all animals weighed at the same ages; thus, we apply it to real data, where such a requirement fails. [ABSTRACT FROM AUTHOR]

The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier with altered ceramide levels and increased loss of transepidermal water. Glucocorticoids are normally employed in the therapeutical management of these pathologies. However, they have shown a poor safety profile and reduced treatment efficiency. The main objective of this review is to, within the framework of the limitations of the currently available therapeutical approaches, establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment. [ABSTRACT FROM AUTHOR]

Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers. [ABSTRACT FROM AUTHOR]