1. Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27.
- Author
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Menaceur, Camille, Dusailly, Océane, Gosselet, Fabien, Fenart, Laurence, and Saint-Pol, Julien
- Subjects
CELL communication ,CASCADE control ,RAS oncogenes ,VESICLES (Cytology) ,CELL physiology ,EXTRACELLULAR vesicles ,PRODUCT elimination ,WASTE products - Abstract
Simple Summary: Vesicle trafficking is governed by the careful regulation of RabGTPase activation/inactivation, which promotes vesicle formation from a donor membrane, motility, docking/tethering and fusion with a recipient membrane. This review highlights the main Rab proteins involved in these processes under physiological conditions, and focuses on the pathophysiological role of the two Rab27 isoforms. This review presents the interest in studying Rab proteins and their effectors in the regulation of vesicular trafficking, and opens the interest of considering them in pathological conditions as outcomes for targeted therapeutical approaches. Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses. This vesicular trafficking also enables the cell to engage in secretory processes for the elimination of waste products or for the emission of intercellular communication vectors such as cytokines, chemokines and extracellular vesicles. Ras-related proteins (Rab) and their effector(s) are of crucial importance in all of these processes, and mutations/alterations to them have serious pathophysiological consequences. This review presents a non-exhaustive overview of the role of the major Rab involved in vesicular trafficking, with particular emphasis on their involvement in the biogenesis and secretion of extracellular vesicles, and on the role of Rab27 in various pathophysiological processes. Therefore, Rab and their effector(s) are central therapeutic targets, given their involvement in vesicular trafficking and their importance for cell physiology. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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