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Air pollution is among the leading global risks for mortality and responsible for increasing risk for chronic diseases. Community perceptions on exposure are critical in determining people's response and acceptance of related policies. Therefore, understanding people' perception is critical in informing the design of appropriate intervention measures. The aim of this paper was to establish levels and associations between perceived pollution and health risk perception among slum residents. A cross-sectional study of 5,317 individuals aged 35+ years was conducted in two slums of Nairobi. Association of perceived score and individual characteristics was assessed using linear regression. Spatial variation in the perceived levels was determined through hot spot analysis using ArcGIS. The average perceived air pollution level was higher among residents in Viwandani compared to those in Korogocho. Perceived air pollution level was positively associated with perceived health risks. The majority of respondents were exposed to air pollution in their place of work with 66% exposed to at least two sources of air pollution. Less than 20% of the respondents in both areas mentioned sources related to indoor pollution. The perceived air pollution level and related health risks in the study community were low among the residents indicating the need for promoting awareness on air pollution sources and related health risks.

Colon cancer is common worldwide and accounts for significant morbidity and mortality in patients. Fortunately, epidemiological studies have demonstrated that continuous therapy with NSAIDs offers real promise of chemoprevention and adjunct therapy for colon cancer patients. Tumour growth is the result of complex regulation that determines the balance between cell proliferation and cell death. How NSAIDs affect this balance is important for understanding and improving treatment strategies and drug effectiveness. NSAIDs inhibit proliferation and impair the growth of colon cancer cell lines when tested in culture in vitro and many NSAIDs also prevent tumorigenesis and reduce tumour growth in animal models and in patients, but the relationship to inhibition of tumour cell proliferation is less convincing, principally due to gaps in the available data. High concentrations of NSAIDs are required in vitro to achieve cancer cell inhibition and growth retardation at varying time-points following treatment. However, the results from studies with colon cancer cell xenografts are promising and, together with better comparative data on anti-proliferative NSAID concentrations and doses (for in vitro and in vivo administration), could provide more information to improve our understanding of the relationships between these agents, dose and dosing regimen, and cellular environment.

In many developing countries, ensuring a stable and affordable supply of safe and nutritious food for urban dwellers, especially impoverished households, has become an urgent policy issue due to growing urban populations. Since urban and peri-urban agriculture (UPA) has emerged as a potential solution, research interest in UPA has increased. However, most studies have been conducted in specific African towns, and analyses in Asian countries are scarce. In addition, further research must be performed on urban and peri-urban livestock farming (UPLF), which may provide animal-based protein to the urban population. Therefore, this study aims to clarify who raises livestock in the urban and peri-urban areas of eight developing Asian countries using raw data from the Demographic and Health Survey (DHS). The aggregation results reveal that at least 10% of households keep livestock, with more than 30% of households in four of the eight Asian countries practicing UPLF. Poultry is the most common type of livestock, and the number of animals per household is usually limited. Logistic regression analysis reveals that poorer families are more likely to raise livestock, suggesting UPLF can enhance food and nutritional security for low-income households. [ABSTRACT FROM AUTHOR]

Research on shantytown transformation in the context of building sustainable human settlements has tended to concentrate on macro and objective factors. However, there is still room for expanding research on the livelihoods of residents in transformed poor communities of resource-based cities. This study is based on household survey data after the coal mine shantytown transformation in Datong, China, and uses the entropy method and Logit regression model to analyze the livelihood level and impact of livelihood capital on the choice of livelihood strategies of the residents after shantytown transformation. Based on the development characteristics of the Datong coal mining community, the traditional sustainable livelihood analysis framework is improved, constructing a livelihood capital evaluation system including natural capital, physical capital, financial capital, social capital, human capital and cultural capital. The research indicates that the livelihoods of the residents after shantytown transformation are in a state of low-value aggregation and differentiation, their livelihood strategies are still dependent on coal mining, financial capital and cultural capital have significant positive impacts on the residents' livelihood strategies of choosing coal mine-related industries, and males and elderly people have a greater likelihood of choosing coal mine-related industries. This study provides micro-level explanations for the livelihood status and livelihood strategy choices of residents after shantytown transformation in a resource-based city and provides policy enlightenment for local governments on how to promote the sustainable development of residents in coal mining communities. [ABSTRACT FROM AUTHOR]

Simple Summary: Para-aortic lymphadenectomy is an essential part of gynecologic oncologic surgical treatment. The surgeon should be aware of the complex usual anatomy and its common variants. Vascular and urinary tract anatomic variants are common and may be found in one out of five patients during para-aortic lymphadenectomy, so the surgeon should always consider them. The most common vascular variant is the accessory renal artery, which is usually not detected on preoperative imaging. An abdominal CT should be interpreted jointly by a radiologist and a surgical gynecologist whenever possible. For optimal intraoperative management, it is strongly recommended that precise dissection be performed to facilitate exposure and provide valuable insight for potential vascular repair. Background: Para-aortic lymphadenectomy is an essential part of gynecologic oncologic surgical treatment. The surgeon should be aware of the complex usual anatomy and its common variants. Methods: Between January 2021 and May 2023, 58 women underwent para-aortic lymphadenectomy for gynecologic malignancies. Results: Vascular and urinary tract anatomic variants were retrospectively reviewed from the prospective institutional database and results were compared with preoperative contrast-enhanced abdominal CT. Of these 58 women, 47 women had no vascular or urinary tract variants. One woman had a double inferior vena cava, two patients were found to have a retro-aortic left renal vein, four had accessory renal arteries, two had a double left ureter, one had a ptotic kidney in the iliac fossa, and one patient had bilateral kidney malrotation. Anatomic variants in the preoperative CT were described by a radiologist in only two patients, and additional vascular and urinary tract variants were found incidentally at the time of surgery. Conclusions: Acknowledgment of vascular and urinary tract variants is helpful for the surgeon to establish an appropriate surgical plan and to avoid iatrogenic surgical trauma. [ABSTRACT FROM AUTHOR]

Physical activity (PA) and emotional intelligence (EI) are integral parts of human nature. Body image (BI) and body mass index (BMI) may be indications of the psycho-emotional and physical health of human beings. The purpose of this study was to investigate the relationship between PA and EI of Greek adults living with overweight and obesity, as well as to identify the BI and EI differences in this population. A cross-sectional study design was used, involving 216 participants (65% females) of whom 51.4% were young adults (20–40 years), 48.6% were middle-aged adults (41–60 years), while 51.4% of participants were living with overweight or obesity. According to the results, all indicators of PA had very low correlations with EI factors, while statistically significant correlations were observed only for PA at work and the total score of the International Physical Activity Questionnaire with the use of emotions (r = 0.16 and r = 0.17, respectively, p < 0.05). Women had significantly higher EI scores than men regarding the care and empathy factor, while the individuals with obesity had lower scores in the use of emotions factor. Regarding BI, young adults who were satisfied with their BI had better control of feelings than the middle-aged adult counterparts. In conclusion, BI satisfaction and EI may differ between individuals living with overweight and obesity in both genders. Younger individuals with obesity may compensate better for their BI and better control their emotions. On the other side, PA does not seem to have an important role in these associations. [ABSTRACT FROM AUTHOR]

Vulgarin, an eudesmanolide sesquiterpene isolated from Artemisia judaica, was refluxed with iodine to produce two derivatives (1 and 2), which were purified and spectroscopically identified as naproxen methyl ester analogs. The reaction mechanism by which 1 and 2 were formed is explained using a sigmatropic reaction with a 1,3 shift. The scaffold hopping via lactone ring opening enabled the new derivatives of vulgarin (1 and 2) to fit well inside the COX-2 active site with ΔG of −7.73 and −7.58 kcal/mol, respectively, which was better than that of naproxen (ΔG of −7.04 kcal/mol). Moreover, molecular dynamic simulations showed that 1 was able to achieve a faster steady-state equilibrium than naproxen. The novel derivative 1 showed promising cytotoxic activities against HepG-2, HCT-116, MCF-7, and A-549 cancer cell lines compared to those of vulgarin and naproxen. [ABSTRACT FROM AUTHOR]

The current study focuses on food consumption and dietary diversity among internal migrant households in Kenya using data from a city-wide household survey of Nairobi conducted in 2018. The paper examined whether migrant households are more likely to experience inferior diets, low dietary diversity, and increased dietary deprivation than their local counterparts. Second, it assesses whether some migrant households experience greater dietary deprivation than others. Third, it analyses whether rural-urban links play a role in boosting dietary diversity among migrant households. Length of stay in the city, the strength of rural-urban links, and food transfers do not show a significant relationship with greater dietary diversity. Better predictors of whether a household is able to escape dietary deprivation include education, employment, and household income. Food price increases also decrease dietary diversity as migrant households adjust their purchasing and consumption patterns. The analysis shows that food security and dietary diversity have a strong relationship with one another: food insecure households also experience the lowest levels of dietary diversity, and food secure households the highest. [ABSTRACT FROM AUTHOR]

Indoor household pollution is not yet sufficiently studied in the general population. Over 4 million people die prematurely every year due to air pollution in households. This study aimed to propose quantitative data research through the administration of a KAP (Knowledge, Attitudes, and Practices) Survey Questionnaire. This cross-sectional study administered questionnaires to adults from the metropolitan city of Naples (Italy). Three Multiple Linear Regression Analyses (MLRA) were developed, including Knowledge, Attitudes, and Behavior regarding household chemical air pollution and the related risks. One thousand six hundred seventy subjects received a questionnaire to be filled out and collected anonymously. The mean age of the sample was 44.68 years, ranging from 21–78 years. Most of the people interviewed (76.13%) had good attitudes toward house cleaning, and 56.69% stated paying attention to cleaning products. Results of the regression analysis indicated that positive attitudes were significantly higher among subjects who graduated, with older age, male and non-smokers, but they were correlated with lower knowledge. In conclusion, a behavioral and attitudinal program targeted those with knowledge, such as younger subjects with high educational levels, but do not engage in correct practices towards household indoor chemical pollution. [ABSTRACT FROM AUTHOR]

Increased urbanization rates pose crucial challenges in terms of food systems' sustainability, including urban food waste (FW). The global narrative around FW has focused mainly on Western countries, but recent evidence shows that FW is also a major issue in the developing world. The objective of this article is to define the characteristics and drivers of urban FW in low- and middle-income countries (LMIC). We firstly present a tailor-made three-step approach to identify urban FW hotspots in LMIC, understand the main drivers and design and implement prevention and reduction interventions considering LMIC food system characteristics. We then draw on results from four different urban FW case studies based in Nairobi (Kenya) and Dhaka (Bangladesh) and discuss their characteristics in light of the proposed approach. The case of Nairobi focuses on quantifying and understanding possible drivers of household FW in Kibera and characterizing FW disposal through a household survey (N = 774). The other three studies examine FW at retail, food service and institutional levels for onions, mangoes and beef in Dhaka. The results confirm that FW happens at the urban supply chain level, particularly among mobile vendors but also among households living below the poverty line. The article thus urges LMIC municipalities to consider urban FW strategies as a key action to tackle food security, environmental issues and FW management challenges. [ABSTRACT FROM AUTHOR]

While the effects of the COVID-19 pandemic on household food security have been documented, the intensity and forms of food insecurity in urban households in the Global South have not been adequately explored. This is despite the emerging consensus that impacts of the pandemic were more severe in urban than rural Africa. This paper addresses this knowledge gap by examining the relationship between pandemic precarity and food insecurity in Ghana's urban areas during the COVID-19 pandemic in 2020. This study is based on the World Bank (WB) and Ghana Statistical Service (GSS) COVID-19 High-Frequency Phone Survey. Using a sub-sample of 1423 urban households, the paper evaluates household experiences of the pandemic. Our findings show that household demographic characteristics are not a major predictor of food insecurity. Economic factors, especially the impact of the pandemic on wage income and total household income, were far more important, with those most affected being most food insecure. Additionally, food-insecure households were most aware of and were affected by food-price increases during the pandemic. These findings are important in planning the post-pandemic recovery initiatives and in addressing current and future emergencies and shocks to urban food systems. [ABSTRACT FROM AUTHOR]

With the recent advances in medicine, human life expectancy is increasing; however, the extra years of life are not necessarily spent in good health or free from disability, resulting in a significantly higher incidence of age-associated pathologies. Among these disorders, neurodegenerative diseases have a significant impact. To this end, the presence of the protective blood–brain barrier (BBB) represents a formidable obstacle to the delivery of therapeutics. Thus, this makes it imperative to define strategies to bypass the BBB in order to successfully target the brain with the appropriate drugs. It has been demonstrated that targeting the BBB by ultrasound (US) can transiently make this anatomical barrier permeable and in so doing, allow the delivery of therapeutics. Thus, our aim was to carry out an in depth in vitro molecular and morphological study on the effects of US treatment on the BBB. The rat brain endothelial (RBE4) cell line was challenged with exposure to 12 MHz diagnostic US treatment for 10, 20, and 30 min. Cell viability assays, Western blotting analysis on the endoplasmic reticulum (ER), and oxidative stress marker evaluation were then performed, along with cytological and immunofluorescence staining, in order to evaluate the effects of US on the intercellular spaces and tight junction distribution of the brain endothelial cells. We observed that the US treatment exerted no toxic effects on either RBE4 cell viability or the upregulation/dislocation of the ER and oxidative stress marker (GRP78 and cytochrome C, respectively). Further, we observed that the application of US induced an increase in the intercellular spaces, as shown by Papanicolaou staining, mainly due to the altered distribution of the tight junction protein zonula occludens-1 (ZO-1). This latter US-dependent effect was transient and disappeared 20 min after the removal of the stimulus. In conclusion, our results show that US induces a transient alteration of the BBB, without altering the intracellular signaling pathways such as the ER and oxidative stress that could potentially be toxic for endothelial cells. These results suggested that US treatment could represent a potential strategy for improving drug delivery to the brain. [ABSTRACT FROM AUTHOR]

Catalyzing change and promoting sustainable cities in informal settlements and their residents requires an understanding of unmet needs and resilience among marginalized and vulnerable groups (MVGs). This is because needs identified on behalf of MVGs as "unmet" are sometimes not perceived as unmet, or even "meetable", and resilience strategies from above are often perceived as unsuitable by the MVGs. To the best of our knowledge, no study has used governance diaries to identify the unmet needs and resilience strategies of MVGs from their perspectives. As such, this study explored the unmet needs and resilience strategies of MVGs in informal settlements using governance diaries. This was a qualitative study using governance diaries with 24 participants from two informal settlements in Nairobi, Kenya. We used Maslow's hierarchy of needs for the framework analysis. We identified unmet needs related to physiology, safety, love and belonging, and self-esteem, in the order of the hierarchy. MVGs did not need the full satisfaction of a lower need to yearn for a higher one, and continue living despite their unmet needs. However, there were no self-actualization needs as the participants could not satisfy the lower level needs. The urban paradox reminds us that cities are not always beneficial for all. There is a continued need for holistic approaches to uncover the often hidden resilience strategies for achieving unmet needs. Our study identified behavioural and cognitive resilience strategies. As such, actors need to embrace and build on local resilience strategies in efforts to address the unmet needs of MVGs in pursuit of inclusive urbanization in Africa. The identification of unmet needs and resilience strategies adds to the literature, policy and practice on how and why residents and MVGs continue working and living in informal settlements despite a lack of or inadequate basic amenities. Our study findings imply that actors in informal settlements need to build on and re-build local resilience strategies in pursuit of inclusive and liveable urbanization in Africa, as unmet needs tend to increase with worsened marginality and vulnerability status. Beyond the resilience strategies adopted by MVGs, governments, service providers and caregivers should take more useful actions to prevent or reduce unmet needs. [ABSTRACT FROM AUTHOR]

Background and Objectives: Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic and, in some cases, neoplastic lesions in human colons. Many studies have confirmed the reduction of ACFs and colorectal adenomas after treatment with acetylsalicylic acid (ASA) commonly referred to as ASA; however, the minimum effective dose of ASA and the duration of use has not been fully elucidated. The objective of our study was to assess the significance of low dose ASA (75-mg internally once daily) to study the chemopreventive effect of ASA in ACF and adenomas development in patients taking this drug for a minimum period of 10 years. Materials and Methods: Colonoscopy, combined with rectal mucosa staining with 0.25% methylene blue, was performed on 131 patients. The number of rectal ACF in the colon was divided into three groups: ACF < 5; ACF 5–10; and ACF > 10. Patients were divided into two groups: the "With ASA" group (the study group subjects taking ASA 75-mg daily for 10 years); and "Without ASA" group (control group subjects not taking ASA chronically). The incidence of different types of rectal ACF and colorectal polyps in both groups of subjects was analysed and ascertained. Results: Normal ACF was found in 12.3% in the study group vs. 87.7% control group, hyperplastic 22.4% vs. 77.6%, dysplastic 25% vs. 75%, mixed 0% vs. 100%. Treatment with ASA affects the occurrence of colorectal adenomas. The amount of dysplastic ACFs was lower in the study group than in the control group. The increase in dysplastic ACFs decreases with age in both groups, with the increase greater in those not taking ASA. Conclusions: Patients who take persistent, chronic (>10 years) low doses of ASA have a lower total number of all types of rectal ACFs and adenomas compared to the control group. [ABSTRACT FROM AUTHOR]

Hunger and food insecurity has worsened due to the COVID-19 pandemic. The types of food environments (e.g., natural/built) that people can access may improve household resilience to food-system shocks. This paper examines (1) urban and rural differences in the perceived influence of the COVID-19 pandemic on agricultural, livelihoods, food environment attributes, diets; and (2) whether access to different food environments was associated with food security. A two-part telephonic survey (COVID-19 Surveillance Community Action Network Food Systems Tool and Household Food Insecurity Access Scale) was conducted in Western Kenya (n = 173) and an informal settlement in Nairobi (n = 144) in January/February 2021. Limitations on the acquisition of farm inputs and movement restrictions had an adverse impact on agriculture and food sales. Urban residents reported a more significant impact on livelihoods (97% vs. 87%, p < 0.001), with day laborers being the most impacted. Rural respondents reported access to significantly more food environments and lower food insecurity. Multiple linear regression analysis revealed that younger respondents, ≤1 income source, had more difficulty acquiring food, decreased access to cultivated environments, and increased access to informal markets were predictors for higher food insecurity. These data indicate that access to specific types of food environments may improve household resilience. [ABSTRACT FROM AUTHOR]

The food environments that people have access to shape their food choices. The purpose of this study was to use mixed methods to characterize the external food environment in informal settlements in Nairobi, Kenya and to examine the individual factors that influence the way in which women interact with those environments to make food choices. We used a combination of food environment assessments (vendor mapping, collection of food prices, food quality assessments) and five focus group discussions with women (n = 26) in four villages within two informal settlements in Nairobi (Mukuru and Kibera) to better understand the drivers of food choice. We found a large number (n = 1163) of vendors selling a variety of food within the settlements. The highest number of vendors were selling fruits and/or vegetables; however, there was limited diversity of fruits available. Animal-source foods were considered relatively expensive as compared to plant-based foods, including prepared fried snacks. We found that the way women interacted with their food environments was influenced by individual factors such as income, time, convenience, and preferences. Our findings suggest that interventions targeting both the external food environment as well as individual factors such as income will be necessary to support healthy diets among low-income populations living in informal settlements in Kenya. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic highlights the need for improving public confidence in vaccines. Academic gaps and redundancies on vaccinations must be identified to revise the medical curriculum for up-to-date training of medical students. This cross-sectional survey assessed the status of vaccine-related teaching in general and specific to COVID-19 in medical schools across Germany. A total of 4313 medical students completed a questionnaire comprising items on national learning goals and perceived needs for teaching on vaccinations. Mixed methods were used to analyse data quantitatively for relative frequencies (%) and correlations between teaching items and semesters (Spearman's rho), and qualitatively (content analysis). Our findings showed that 38.92% of the students were dissatisfied with teaching on vaccine-preventable diseases, but the perceived satisfaction increased in later semesters (r = 0.46, p < 0.001). Moreover, 75.84% and 68.15% of the students were dissatisfied with teaching related to vaccine scepticism and vaccine-related communication strategies, respectively. Furthermore, 63.79% reported dissatisfaction with teaching on COVID-19 disease and 72.93% with teaching on COVID-19 vaccines. A total of 79.12% stated they educated others on COVID-19 and its vaccines and 75.14% felt responsible to do so. A majority of the medical students were dissatisfied with teaching on dealing with vaccine scepticism, communication strategies and COVID-19 vaccines. We recommend practice-oriented vaccine education, especially for teaching communication skills to medical students. [ABSTRACT FROM AUTHOR]

The aim of this study is to disclose the social factors of sustainable development goals by exploring the links between three types of social capital (bonding, bridging and linking) and food security in Kibera, an informal settlement located in Nairobi, Kenya. Several studies in the literature have addressed links between food security and social capital. However, a lack of theoretical approaches exist in the literature, which concern the sustainable development theory devoted to urban areas taking into account the sustainable development goals. This study applies a linear regression model on data from 385 households in Kibera to analyze the connection between food security and three types of social capital (bonding, bridging and linking). The results demonstrate that there is a positive impact between our proxies for bonding social capital (cultural diversity and the number of visits to area of origin) and food security. Bridging social capital (measured by trust in strangers) demonstrated a negative impact on food security. Finally, one indicator for linking social capital demonstrated a positive impact on food security (trust in community leaders), whereas the statistical analyses did not find any relationship of the two indicators; 'trust in local politicians' and 'membership of social organisations', with food security. The results demonstrate that insight into social capital can inform the understanding of household food insecurity in vulnerable urban settlements, by illustrating the critical impacts of social drivers in a food system. [ABSTRACT FROM AUTHOR]

The air quality (AQ) in urban contexts is a major concern, especially in the developing world. The environmental and social challenges created by poor AQ have continued to increase despite improvements in monitoring AQ using earth observation (EO) satellites, static and mobile ground-based sensors and models. However, these types of equipment can be expensive to purchase, operate, and maintain, especially for cities of the developing world, and, as a result, there is growing interest in the elicitation of residents' perceptions of AQ. However, there is a need to analyse how the results obtained from sensor measurements and models match the AQ as perceived by residents. This study explored AQ in multiple locations in two developing world cities (Abuja and Enugu) in Nigeria by analysing the perceptions of 262 residents and how these compared with findings obtained from ground-based instruments. The results suggest that the perceived AQ of the locations broadly matches those obtained using instruments, although there were statistically significant differences between respondent groups based on the demographic factors of income-education (Abuja) and age (Enugu). This research supports the contention that perceptual AQ assessment provides a valuable source of data for policy and decision-makers when addressing poor AQ and can support action in the absence of instrument-based measurements. [ABSTRACT FROM AUTHOR]

Ultrasonic waves are mechanical waves with a frequency greater than 20,000 Hz. Ultrasonic waves are emitted by devices that are used in industry or that have a medical or aesthetic purpose. There is growing interest in the effect of ultrasound absorption on the human body, since people's exposure to these acoustic waves has increased considerably in recent years. There are more and more devices that emit ultrasounds used for different sanitary procedures, aesthetic treatments and industrial processes, creating more possibilities of ultrasound noise, and therefore an increased risk of occupational hazard and occupational danger. Experiments on animals have shown damage to internal organs from receiving different ultrasonic frequencies. The main task of this work was to organize and summarize recent studies on ultrasound to reflect the current state of this technique and establish a systematic basis for future lines of research. This work has allowed us to better understand the unknown field of these high frequencies of sound, and highlights the need to carry out more studies on the ultrasound emissions that can be absorbed by the human body to determine how this energy could affect humans by calculating the maximum dose of exposure and developing manuals for the use of ultrasound-emitting equipment to protect the health of workers and all people. It is necessary to develop regulations by public administrations to improve the protection of workers, health professionals, patients and all people in general for better occupational safety, indoor environmental quality and environmental health. [ABSTRACT FROM AUTHOR]

Analysis of colonoscopy images plays a significant role in early detection of colorectal cancer. Automated tissue segmentation can be useful for two of the most relevant clinical target applications-lesion detection and classification, thereby providing important means to make both processes more accurate and robust. To automate video colonoscopy analysis, computer vision and machine learning methods have been utilized and shown to enhance polyp detectability and segmentation objectivity. This paper describes a polyp segmentation algorithm, developed based on fully convolutional network models, that was originally developed for the Endoscopic Vision Gastrointestinal Image Analysis (GIANA) polyp segmentation challenges. The key contribution of the paper is an extended evaluation of the proposed architecture, by comparing it against established image segmentation benchmarks utilizing several metrics with cross-validation on the GIANA training dataset. Different experiments are described, including examination of various network configurations, values of design parameters, data augmentation approaches, and polyp characteristics. The reported results demonstrate the significance of the data augmentation, and careful selection of the method's design parameters. The proposed method delivers state-of-the-art results with near real-time performance. The described solution was instrumental in securing the top spot for the polyp segmentation sub-challenge at the 2017 GIANA challenge and second place for the standard image resolution segmentation task at the 2018 GIANA challenge. [ABSTRACT FROM AUTHOR]

Exposure to air pollution is associated with adverse health outcomes. However, the health burden related to ambient outdoor air pollution in sub-Saharan Africa remains unclear. This study examined the relationship between exposure to outdoor air pollution and child health in urban slums of Nairobi, Kenya. We conducted a semi-ecological study among children under 5 years of age from two slum areas and exposure measurements of particulate matter (PM2.5) at the village level were aligned to data from a retrospective cohort study design. We used logistic and Poisson regression models to ascertain the associations between PM2.5 exposure level and child morbidity and mortality. Compared to those in low-pollution areas (PM2.5 < 25 µg/m³), children in high-pollution areas (PM2.5 ≥ 25 µg/m³) were at significantly higher risk for morbidity in general (odds ratio (OR) = 1.25, 95% confidence interval (CI): 1.11-1.41) and, specifically, cough (OR = 1.38, 95% CI: 1.20-1.48). Exposure to high levels of pollution was associated with a high child mortality rate from all causes (IRR = 1.22, 95% CI: 1.08-1.39) and respiratory causes (IRR = 1.12, 95% CI: 0.88-1.42). The findings indicate that there are associated adverse health outcomes with air pollution in urban slums. Further research on air pollution health impact assessments in similar urban areas is required. [ABSTRACT FROM AUTHOR]

African cities face immense challenges over the coming decades. As countries urbanize, African cities must maintain service provision for rapidly increasing populations, yet with limited resources. In particular, urban food systems must be able to cope with regional food shortages and catalyze (or at least enable) the distribution of food from diverse sources in order to ensure that the cost of food remains affordable for all of the segments of a city's population. Food systems in most African cities are composed of wholesale sellers, formal markets, street vendors, shops, and increasingly large-scale international stores, creating an evolving landscape of food sources. At the same time, urban population growth can result in rapid changes in urban structure with new peri-urban development and transitions in socioeconomic status within existing areas. Governance plays an important role in the creation and coordination of formal and informal actors across different types of food providers. At the municipal level, new markets must be approved to keep pace with urban expansion. Within residential areas, market management committees must work to maintain traditional markets in the context of increasing competition from large-scale grocers and small-scale street vendors. We use household and market-level data that was collected in Lusaka, Zambia, to conduct an institutional analysis of residential areas to examine the interplay between households, public markets, and street vendors. Analysis of the city's food system identifies a complex network of relationships featuring formal and informal governance arrangements, which may affect food system functionality. [ABSTRACT FROM AUTHOR]

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-κB signaling has potential therapeutic applications in cancer and inflammatory diseases. [ABSTRACT FROM AUTHOR]

Increasing air temperature coupled with high humidity due to ongoing climate change across most parts of South Africa is likely to induce and intensify heat exposure, particularly in densely populated areas. The adverse health implications, including heatstroke, are expected to be common and more severe during extreme heat and heat wave events. The present study was carried out to examine heat stress conditions and long-term trends in South Africa. The study aimed to identify geographical locations exposed to elevated heat stress based on over two decades of hourly ground-based data. Selected heat stress indicators were calculated based on Steadman's apparent temperature (AT in °C). The trends in AT were assessed based on the non-parametric Mann–Kendall (MK) trend test at 5% significance level. Positive trends were detected in 88% of the selected weather stations except in Welkom-FS, Ficksburg-FS, Langebaanweg-WC, Lambertsbaai Nortier-WC, Skukuza-MP, and Thabazimbi-LP. Approximately 47% of the detected positive trends are statistically significant at 5% significant level. Overall, high climatological annual median (ATmed) values (>32 °C) were observed at 42 stations, most of which are in low altitude regions, predominately along the coastlines. The hottest towns with ATmed values in the danger category (i.e., 39–50 °C) were found to be Patensie-EC (41 °C), Pietermaritzburg-KZN (39 °C), Pongola-KZN (39 °C), Knysna-WC (39 °C), Hoedspruit-LP (39 °C), Skukuza-MP (45 °C), and Komatidraai-MP (44 °C). The results provide insight into heat stress characteristics and pinpoint geographical locations vulnerable to heat stress conditions at the community level in South Africa. Such information can be useful in monitoring hotspots of heat stress and contribute to the development of local heat–health adaptation plans. [ABSTRACT FROM AUTHOR]

Simple Summary: Streptococcosis, a warm-water pathogenic bacteria, has greatly affected red hybrid tilapia production in Malaysia over the years, causing mass mortality in various culture systems. Probiotics have been used to treat and prevent bacterial diseases, including streptococcosis, yet they require constant application to ensure that their concentration is adequate. Incorporating probiotics in a biofloc system may reduce this issue as the effective microorganism may further flourish and be utilized by the fish. The objectives of this study were to evaluate the influence of probiotic addition on the growth performance and water quality of red hybrid tilapia. From the study, it was observed that a probiotic mix was able to inhibit Streptococcus spp., improve red hybrid tilapia performance and disease resistance against streptococcosis. Providing a beneficial mix of probiotics can effectively improve biofloc culture in red hybrid tilapia culture. Biofloc technology has shown positive effects in aquaculture, especially on the growth performance of cultured animals. The aims of this study were to evaluate the effects of adding different probiotic strains in a biofloc system on the growth performance and disease resistance of red hybrid tilapia (Oreochromis spp.). Three different probiotics (Lysinibacillus fusiformis SPS11, Bacillus amyloliquefaciens L9, and Enterococcus hirae LAB3), commercial probiotics (MG1) and a mixed probiotics (MP) combining all three strains were used in this study. The in vitro assay results showed that the mixed probiotic (MP) was able to inhibit the growth of Streptococcus agalactiae and Streptococcus iniae significantly compared to the single and commercial probiotic. The efficacy of MP was further tested in in vivo tilapia culture challenged with S. agalactiae. The best specific growth rate (3.73 ± 0.23% day−1) and feed conversion ratio (0.76 ± 0.04) were recorded in the group of biofloc with addition of MP. After being challenged with S. agalactiae, the group of biofloc with MP had significantly higher survival (83 ± 1.43%) compared to the other groups. Furthermore, the nitrogen concentration (NO2-N and NH4-N) was significantly lower in all the biofloc groups compared to the control. Hence, the addition of probiotics was able to provide beneficial effects to red hybrid tilapia culture in the biofloc system. [ABSTRACT FROM AUTHOR]

Kibera, the largest slum in Nairobi, Kenya, is increasing in size and complexity due to migration from rural areas. Reaching the objectives of zero hunger and sustainable cities and communities (SDGs2 and 11) are urgent and complex challenges to future development. In this survey a new fish value-chain has been set up between a rural area called Nyeri district and the inhabitants of Kibera, to supply small-sized affordable and accessible fish. The main aim of this article is to investigate this best practice example to assist future initiatives to overcome the complex challenges and discuss reasons why it was successful. The methods applied to obtain information to conduct this survey include a literature review, two workshops, and five preparatory interviews of Kibera inhabitants. The contributions by two community leaders, one in Kibera and one in Nyeri, are central to understand why this project was successful. The community leaders were trusted in their local networks. To ensure a resilient rural-urban food system in the future, it is critically important to understand context-specific institutional mechanisms, which in Kenya are based in communities run by strong community leads with capacities to motivate and influence other actors in the network to improve and make changes. [ABSTRACT FROM AUTHOR]

This paper reports on the indoor and outdoor air quality in informal urban and rural settlements in Kenya. The study is motivated by the need to improve consciousness and to understand the harmful health effects of air quality to vulnerable people, especially in poor communities. Ng'ando urban informal settlement and Leshau Pondo rural village in Kenya are selected as representative poor neighborhoods where unclean energy sources are used indoor for cooking, lighting and heating. Filter based sampling for gravimetrical, elemental composition and black carbon (BC) analysis of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) is performed. findings from Ng'ando and Leshau Pondo showed levels exceeding the limit suggested by the world health organization (WHO), with rare exceptions. Significantly higher levels of PM2.5 and black carbon are observed in indoors than outdoor samples, with a differences in the orders of magnitudes and up to 1000 µg/m3 for PM2.5 in rural settlements. The elemental composition reveals the presence of potentially toxic elements, in addition to characterization, emission sources were also identified. Levels of Pb exceeding the WHO limit are found in the majority of samples collected in the urban locations near major roads with heavy traffic. Our results demonstrate that most of the households live in deplorable air quality conditions for more than 12 h a day and women and children are more affected. Air quality condition is much worse in rural settlements where wood and kerosene are the only available fuels for their energy needs. [ABSTRACT FROM AUTHOR]

This paper discusses how local-level food systems, social remediation and environmental restoration can be linked to increase stability and build resilience inside extremely vulnerable communities. Specifically, it details how food culture entwines with socio-environmental restoration to benefit three low-income urban and peri-urban communities located in Thailand, India and Brazil. It aims to add to an existing body of knowledge that resides at the nexus of food, socio-environmental restoration and informality. It details effective, proven initiatives that have been regionally replicated to support marginalized communities to better cope with the negative effects of simultaneous stressors. It posits that imaginative visioning can be applied to simultaneously cultivate food security, remediate neglected lands and improve socio-economic opportunity. It provides a contribution to the field of social-ecological restoration planning in relation to food studies in lowest-income contexts. [ABSTRACT FROM AUTHOR]

Underutilised indigenous plants can support and strengthen the existing food system, as they are considered as socio-economically and environmentally appropriate. These plants generally adapt to marginal conditions, which is essential for a resilient agriculture and sustainable food systems. The current study relied on food security and indigenous plants data collected from some selected rural households from the North West Province of South Africa. The utilised data were collected through a multi-stage sampling technique with the aid of a pre-tested semi-structured questionnaire, while descriptive methods Foster–Greer–Thorbecke (FGT) and binary logistic regression were used for data analysis. The models produced a good fit for the data, and the computed F-value was statistically significant (p < 0.01). The study examined socio-economic and food security status based on the knowledge and the perception of indigenous plants by the households. The incidence of food insecurity (θ0) was 0.4060, indicating that 40.6% of the participants were food insecure while 59.4% were food secured. Binary logistic regression results indicate that factors such as age, gender, educational attainment, inclusion of indigenous plants in diet, food expenditure, and access in the study area impacted results. It was also evident that the participants had considerable knowledge of indigenous plants. However, these indigenous plants were not cultivated or included in the diet by the majority of the participants. The formulation of appropriate holistic policies that support the incorporation of the indigenous plants into the food system is recommended. [ABSTRACT FROM AUTHOR]

The impacts of fine particulate matter (PM2.5) air pollution on health outcomes, especially those of children, have attracted worldwide attention. Based on the PM2.5 concentration data of 94 countries, including the least developed countries estimated by satellite observations in nearly 20 years, this paper investigated the impacts of PM2.5 pollution on under-five mortality rate (U5MR) and analyzed the role of public service in moderating the PM2.5-mortality relationship. Results indicated that PM2.5 pollution had significantly positive influence on U5MR globally. However, the effects of fine particulate pollution on child mortality were heterogeneous in terms of their significance and degrees in countries with different levels of development. A further test based on panel threshold model revealed that public service, measured by public education spending and sanitation service, played a positive moderating role in the PM2.5-mortality relationship. Specifically, when the ratio of public education expenditure in GDP of a country exceeded the first threshold value 3.39% and the second threshold value 5.47%, the magnitude of the impacts of PM2.5 pollution on U5MR significantly decreased accordingly. When the percentage of population with access to improved sanitation facilities in a country was over 41.3%, the health damaging effects were reduced by more than half. This paper fills the current gap of PM2.5 research in least developed countries and provides key policy recommendations. [ABSTRACT FROM AUTHOR]

Anthocyanins are a class of water-soluble flavonoids widely present in fruits and vegetables. Dietary sources of anthocyanins include red and purple berries, grapes, apples, plums, cabbage, or foods containing high levels of natural colorants. Cyanidin, delphinidin, malvidin, peonidin, petunidin, and pelargonidin are the six common anthocyanidins. Following consumption, anthocyanin, absorption occurs along the gastrointestinal tract, the distal lower bowel being the place where most of the absorption and metabolism occurs. In the intestine, anthocyanins first undergo extensive microbial catabolism followed by absorption and human phase II metabolism. This produces hybrid microbial–human metabolites which are absorbed and subsequently increase the bioavailability of anthocyanins. Health benefits of anthocyanins have been widely described, especially in the prevention of diseases associated with oxidative stress, such as cardiovascular and neurodegenerative diseases. Furthermore, recent evidence suggests that health-promoting effects attributed to anthocyanins may also be related to modulation of gut microbiota. In this paper we attempt to provide a comprehensive view of the state-of-the-art literature on anthocyanins, summarizing recent findings on their chemistry, biosynthesis, nutritional value and on their effects on human health. [ABSTRACT FROM AUTHOR]