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Simple Summary: The intricate interplay of behavioral paths within animal groups, governed by dominance hierarchies, poses a challenge in identifying the pivotal node within the complex causal network of exploratory behaviors leading to aggression formation. Here, based on the strong curiosity of pigs and their competitive biological characteristics among conspecifics, two consecutive experiments were designed, aimed at investigating the behavioral transition paths and pivotal nodes governing aggression between two unfamiliar individuals upon initial encounter under controlled conditions. In Experiment 1, pigs that were mixed together showed short behavioral paths, primarily involving direct aggression, with a sequence of looking followed by attacking. In contrast, Experiment 2 involved adding new pigs to resident groups, leading to a more detailed sequence of behaviors. Resident pigs first engaged in a series of behaviors—looking, sniffing, touching—before transitioning to aggression. The study identified eight types of behavioral transition paths ranging from short, direct interactions to longer, more exploratory sequences. In both experiments, aggression was a common outcome, but Experiment 1 mainly showed brief exploratory pathways ending in aggression, while Experiment 2 revealed a variety of longer exploratory pathways involving multiple behaviors before aggression. This research highlights the complex nature of interactions between unfamiliar pigs and how their behaviors evolve during encounters. This study leverages the inherent curiosity of pigs and their competitive nature among conspecifics to explore behavioral transition paths and critical nodes that govern aggression during initial encounters between unfamiliar individuals. Two consecutive experiments were designed to investigate these dynamics under controlled conditions. In Experiment 1, unfamiliar pigs engaged in one-on-one fights with quick retreats, displaying a simple behavioral sequence of looking followed by attacking. In Experiment 2, the addition of new pigs to resident groups resulted in a more complex and structured behavioral sequence. Resident pigs exhibited a 'four-step' exploratory behavior pattern: looking, sniffing, touching, and attacking. Further analysis revealed distinct exploratory pathways. In Experiment 1, only short behavioral paths were observed, while Experiment 2 revealed both long and short paths. Specifically, Experiment 2 uncovered seven types of behavioral transition paths, four of which were long and three short, highlighting different combinations of the basic behaviors. The transition paths involving aggression were more varied in Experiment 2 compared to Experiment 1. Overall, the 15 most frequent and obvious behavioral transition paths were identified across both experiments. Eight types of paths were categorized based on the transitions between the basic behaviors. These findings enhance our understanding of the behavioral dynamics in unfamiliar pig encounters, emphasizing the complexity of social interactions and the conditions under which aggression occurs. [ABSTRACT FROM AUTHOR]

Simple Summary: Detour behavior refers to the ability to reach a goal object that is not directly accessible due to an obstacle (opaque or transparent) by circumventing it. It varies among species, suggesting that environmental adaptation may drive insight behavior. Some species of marine and freshwater fish were placed in a corridor with social stimuli at the end, not directly accessible due to an opaque barrier. Two symmetrical apertures positioned midline in the corridor allowed the fish to temporarily abandon the view of the goal and attempt to circumvent the barrier. All fish showed the ability to move around an interposed obstacle. This is the first evidence of detour behavior in marine fishes within the "four-compartment box task", while results in freshwater fishes confirmed previous evidence. The comparable performance of marine and freshwater fishes suggests similar selective ecological pressure even in different aquatic habitats (e.g., sea and freshwater basins). Moreover, different exploratory behaviors emerged between correct and incorrect compartments (particularly in Danio rerio), providing evidence for a possible mental representation or "permanence in existence" of the goal while performing the obstacle circumvention, as opposed to a more parsimonious idea suggesting that the detour ability emerges only from primitive forms of exploratory behavior such as taxis. Evidence of detour ability to reach a salient goal in marine fishes (Chromis viridis, Chrysiptera parasema, Dascyllus aruanus) and freshwater fishes (Xenotoca eiseni, Danio rerio) has been observed using a "four-compartment box task" with an opaque barrier. The first experiment investigated this ability in marine fishes (Chromis viridis, Chrysiptera parasema, Dascyllus aruanus). Fish were placed in a four-compartment box, with social stimuli not accessible due to an opaque barrier. Two symmetrical apertures midline in the corridor allowed the fish to temporarily abandon the goal's view and attempt to circumvent the barrier. Marine fish showed searching behavior in the two compartments near the social stimuli. In the second experiment, the detour abilities of a marine fish (Dascyllus aruanus) and two freshwater fishes (Xenotoca eiseni, Danio rerio) were compared using a modified version of the apparatus, with elongated compartments continuing further from the obstacle barrier and social stimuli. This enabled the evaluation of the dependence on effective distance to achieve the social goal. Both marine and freshwater fish exhibited detour skills. Additionally, Danio rerio's differential spatial explorations inside compartments supported an active interest in searching for conspecifics, suggesting possible social object permanence retention. Overall, these results highlight the ecological salience of detour skills in fishes, irrespective of species-specific adaptations. [ABSTRACT FROM AUTHOR]

Curiosity and question-asking are at the heart of science and engineering education. However, question-asking can be difficult for students due to several factors, including fear, language barriers, and cultural norms. This is especially true among Chinese students, who represent a growing number of upcoming engineers. To address this, in this case study from a university teaching reform project, we investigate the perceptions of curiosity and question-asking among Chinese science, technology, engineering, and mathematics (STEM) undergraduate students following a newly developed semester-long project in a second-year communications course at a recently established Sino-foreign engineering school in China. In this period, students engaged in project-based learning centered around Nobel Prize-winning research, allowing them to explore the driving questions behind groundbreaking discoveries. Through a combination of qualitative analyses from students' personal reflections as well as from a post-survey, the study examines students' perceptions of curiosity and question-asking, the influence of gender on these skills, and the role of failure and perseverance in scientific inquiry. Findings indicate that the project increased students' curiosity and improved their confidence in asking questions while providing insights into gender differences. Moreover, students were inspired by the curiosity of the Nobel Laureates, by the "simplicity" of the questions asked, and by the great importance of tenacity, passion, and learning from mistakes. [ABSTRACT FROM AUTHOR]

Storytelling is one of the most important learning activities for children since reading aloud from a picture book stimulates children's curiosity, emotional development, and imagination. For effective education, the procedures for storytelling activities need to be improved according to the children's level of curiosity. However, young children are not able to complete questionnaires, making it difficult to analyze their level of interest. This paper proposes a method to estimate children's curiosity in picture book reading activities at five levels by recognizing children's behavior using acceleration and angular velocity sensors placed on their heads. We investigated the relationship between children's behaviors and their levels of curiosity, listed all observed behaviors, and clarified the behavior for estimating curiosity. Furthermore, we conducted experiments using motion sensors to estimate these behaviors and confirmed that the accuracy of estimating curiosity from sensor data is approximately 72%. [ABSTRACT FROM AUTHOR]

Curiosity is one of the most fundamental biological drives that stimulates individuals' intense desire to explore, learn, and create. Yet, mechanisms of how curiosity is influenced by instructional pedagogy remain unclear. To shed light on this gap, the present study sets out to investigate the underlying channels linking active learning pedagogy, learner engagement, and learner curiosity, employing a partial least-squares structural equation model leveraging the Social and Emotional Skills Survey dataset across ten sites (N = 45,972). Findings indicate that active learning pedagogy is positively associated with learner engagement (std. β = 0.016, p = 0.005), but there lacks a significant direct effect on learner curiosity (std. β = −0.001, p = 0.738). Structural mediation results show that learner engagement is a key mediating channel linking active learning pedagogy and learner curiosity (std. β = 0.013, p = 0.005). [ABSTRACT FROM AUTHOR]

An intensive breeding environment usually sacrifices the biological needs of pigs and will have a negative impact on the welfare and production efficiency of pigs. In this study, a bedding elevated platform rearing system was established and its effect on the welfare of fattening pigs was evaluated. A total of 456 fattening pigs were divided into the elevated platform rearing system group (EP) and control group (CON). The welfare of pigs during the rearing period (57–97 days of age) and the fattening periods (98–168 days of age) was assessed through behavioral observation, physiological indicators, growth performance, and bone quality. Pigs in the EP group showed less manipulating behavior and more playing behavior than pigs in the CON group during the first 48 h of the test. Moreover, EP pigs expressed more standing, play, and exploratory behaviors and less sitting, lying down, manipulating, and fighting behaviors than the CON pigs during the rearing period. More standing and playing behavior and less sitting, manipulating behavior, and fighting behavior were expressed in the EP group than the CON group during the fattening period. In both of the rearing and fattening periods, serum cortisol concentrations were lower in the EP group than the CON group; C-reactive protein concentrations were significantly higher in the EP group than CON group; TNF-α, IFN-γ, IL-1β, IL-2, IL-6, IgA, IgG, and IgM levels were significantly higher in the EP group than the CON group, but IL-10 levels were significantly lower in the EP group than the CON group. The EP group had less skin lesions and a higher final body weight. Our study confirms that the enriched elevated platform rearing system promotes the expression of positive behaviors and reduced skin and limb lesions, which also improve the growth performance of pigs. [ABSTRACT FROM AUTHOR]

The use of electronic cigarettes (ECs) is a major problem globally. Susceptibility and curiosity are important factors that develop prior to the onset of substance use, such as ECs, and are therefore considered as predictors. Both factors are used to obtain an extended index of susceptibility (ESIe-c), which allows the identification of adolescents who are at risk of starting to use these devices. The aim of this study was to determine the prevalence of EC consumption and to assess the association of possible predictors with susceptibility to use and experimentation with ECs among adolescents. A cross-sectional study was carried out in 377 adolescents (53.0% female). Participants were compared according to their experimentation with ECs. A total of 45.9% had already used electronic cigarettes, and 20.8% were current users. Among those who had not tried electronic cigarettes, 43.3% had a medium-high susceptibility to EC initiation. Consumption among close friends, receiving offers of consumption and alcohol consumption were associated with initiation. There was an inverse association between a medium susceptibility index electronic cigarette score and the consumption of cigarettes and positive affect; on the other hand, the lack of premeditation was associated with a higher susceptibility index score. Intrapersonal factors and social factors seem to influence the ESIe-c and onset of EC use, respectively. The main conclusion in this study is that susceptibility is influenced by intrapersonal factors such as affectivity and impulsivity through the lack of premeditation, and by social factors such as EC consumption by best friends. [ABSTRACT FROM AUTHOR]

An existential vacuum is experienced as a kind of crisis that one can cope with using his/her strengths. The related literature suggests that the important determinants of coping with existential emptiness include positive emotional and personality resources, and among these—Curiosity Behaviors. The purpose of this study is to describe the role of curiosity as an important factor in relation to emotional resources in individuals experiencing an existential vacuum. A survey was conducted using online tools (n = 484). The hypotheses about the direct and indirect relationships between Curiosity Behaviors and existential vacuum were tested using multiple regression analyses and mediations. The study involved a sample of adult participants representing the general population. The participants completed five questionnaires, the first one focusing on Curiosity Behaviors, such as seeking out novel and challenging experiences and engagement in activities that capture one's attention (The Curiosity and Exploration Inventory), and the other tools being the Multidimensional Existential Meaning Scale, the Emotional Regulation Questionnaire, the Flourishing Scale, and the Depression Anxiety Stress Scale. The results indicate that Curiosity Behaviors characteristically negatively predict existential vacuum. In addition, other variables, such as Flourishing, seem to be useful in explaining the relationships between these factors. Flourishing along with Curiosity increases a sense of Meaning in Life. Our results present evidence showing the importance of Curiosity Behaviors in coping with the existential vacuum. [ABSTRACT FROM AUTHOR]

The swift advancements in robotics have rendered navigation an essential task for mobile robots. While map-based navigation methods depend on global environmental maps for decision-making, their efficacy in unfamiliar or dynamic settings falls short. Current deep reinforcement learning navigation strategies can navigate successfully without pre-existing map data, yet they grapple with issues like inefficient training, slow convergence, and infrequent rewards. To tackle these challenges, this study introduces an improved two-delay depth deterministic policy gradient algorithm (LP-TD3) for local planning navigation. Initially, the integration of the long–short-term memory (LSTM) module with the Prioritized Experience Re-play (PER) mechanism into the existing TD3 framework was performed to optimize training and improve the efficiency of experience data utilization. Furthermore, the incorporation of an Intrinsic Curiosity Module (ICM) merges intrinsic with extrinsic rewards to tackle sparse reward problems and enhance exploratory behavior. Experimental evaluations using ROS and Gazebo simulators demonstrate that the proposed method outperforms the original on various performance metrics. [ABSTRACT FROM AUTHOR]

Mobile robot olfaction of toxic and hazardous odor sources is of great significance in anti-terrorism, disaster prevention, and control scenarios. Aiming at the problems of low search efficiency and easily falling into a local optimum of the current odor source localization strategies, the paper proposes the adaptive space-aware Infotaxis II algorithm. To improve the tracking efficiency of robots, a new reward function is designed by considering the space information and emphasizing the exploration behavior of robots. Considering the enhancement in exploratory behavior, an adaptive navigation-updated mechanism is proposed to adjust the movement range of robots in real time through information entropy to avoid an excessive exploration behavior during the search process, which may lead the robot to fall into a local optimum. Subsequently, an improved adaptive cosine salp swarm algorithm is applied to confirm the optimal information adaptive parameter. Comparative simulation experiments between ASAInfotaxis II and the classical search strategies are carried out in 2D and 3D scenarios regarding the search efficiency and search behavior, which show that ASAInfotaxis II is competent to improve the search efficiency to a larger extent and achieves a better balance between exploration and exploitation behaviors. [ABSTRACT FROM AUTHOR]

Chemotherapy-induced cognitive impairment or "chemobrain" is a prevalent long-term complication of chemotherapy and one of the more devastating. Most of the studies performed so far to identify the cognitive dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered to breast cancer patients, a population that, after treatment, shows a high possibility of long survival and, consequently, of chemobrain development. In the last few years, different possible strategies have been explored to prevent or reduce chemobrain induced by the anthracycline doxorubicin (DOX), known to promote oxidative stress and inflammation, which have been strongly implicated in the development of this brain dysfunction. Here, we have critically analyzed the results of the preclinical studies from the last few years that have evaluated the potential of phenolic compounds (PheCs), a large class of natural products able to exert powerful antioxidant and anti-inflammatory activities, in inhibiting DOX-induced chemobrain. Several PheCs belonging to different classes have been shown to be able to revert DOX-induced brain morphological damages and deficits associated with learning, memory, and exploratory behavior. We have analyzed the biological and molecular mechanisms implicated and suggested possible future perspectives in this research area. [ABSTRACT FROM AUTHOR]

The central nervous system (CNS) is the final frontier in drug delivery because of the blood–brain barrier (BBB), which poses significant barriers to the access of most drugs to their targets. Kynurenic acid (KYNA), a tryptophan (Trp) metabolite, plays an important role in behavioral functions, and abnormal KYNA levels have been observed in neuropsychiatric conditions. The current challenge lies in delivering KYNA to the CNS owing to its polar side chain. Recently, C-3 side chain-modified KYNA analogs have been shown to cross the BBB; however, it is unclear whether they retain the biological functions of the parent molecule. This study examined the impact of KYNA analogs, specifically, SZR-72, SZR-104, and the newly developed SZRG-21, on behavior. The analogs were administered intracerebroventricularly (i.c.v.), and their effects on the motor domain were compared with those of KYNA. Specifically, open-field (OF) and rotarod (RR) tests were employed to assess motor activity and skills. SZR-104 increased horizontal exploratory activity in the OF test at a dose of 0.04 μmol/4 μL, while SZR-72 decreased vertical activity at doses of 0.04 and 0.1 μmol/4 μL. In the RR test, however, neither KYNA nor its analogs showed any significant differences in motor skills at either dose. Side chain modification affects affective motor performance and exploratory behavior, as the results show for the first time. In this study, we showed that KYNA analogs alter emotional components such as motor-associated curiosity and emotions. Consequently, drug design necessitates the development of precise strategies to traverse the BBB while paying close attention to modifications in their effects on behavior. [ABSTRACT FROM AUTHOR]

This research examines the potential social benefits of displaying curiosity during a negotiation. Past research has found women who ask directly in distributive agentic settings can suffer negative social consequences and obtain worse objective outcomes compared to men. In three experiments (N = 600) using different negotiation contexts, we found men and women who approach negotiations with curiosity reap the same economic benefits of asking directly but without incurring a social cost. We also found that perceived warmth partially accounts for the positive effects of curiosity (vs. asking directly) on negotiators' social outcomes. Finally, our results reveal women feel more comfortable conveying curiosity compared to using a direct approach in their negotiations. We discuss the implications of these findings in enhancing negotiation effectiveness for both women and men. [ABSTRACT FROM AUTHOR]

Background: The present research relied on the affective events theory to develop a framework explaining how daily micro-events trigger affective reactions that, in turn, influence quality-of-life indicators (i.e., psychological well-being and COVID-19 stress). We further delineated theoretical arguments for curiosity as a boundary condition that moderated this relation and proposed the dark triad (Machiavellianism, narcissism, and psychopathy) as a threatening factor. Methods: We conducted two studies to test the model. Study one analyzed the moderated mediation model regarding COVID-19 stress (n = 241), and study two (n = 653) analyzed the model regarding psychological well-being as the outcome. Results: Study one demonstrated that daily hassles increased COVID-19 stress via a negative effect, but this was not contingent on the levels of curiosity and the dark triad traits. However, the mediating path of positive affect between daily uplifts and COVID-19 stress was conditional upon the levels of curiosity and the dark triad traits (Machiavellianism and psychopathy), such that when individuals scored high on curiosity and dark traits, the indirect effect became stronger. The results showed that narcissism did not moderate the moderated mediation relationship. Study two showed that daily uplifts boosted psychological well-being through positive affect, and this relation was dependent on curiosity and on the three dark traits, such that it became weaker as curiosity decreased and the dark triad traits increased. We also found that daily hassles, by triggering negative affect, decreased psychological well-being, in particular for those who scored lower on curiosity and higher on psychopathy and narcissism (but not for Machiavellianism). Conclusions: Overall, COVID-19 stress seems to be more responsive to daily hassles than to daily uplifts. Nevertheless, when daily uplifts are factored in, they foster a sense of well-being that helps reduce COVID-19-related stress, especially in individuals who are naturally curious and exhibit high levels of Machiavellian and psychopathic traits. Conversely, psychological well-being appears to be more influenced by situational factors, as it is affected by both types of daily micro-events. We discuss the implications of both studies in light of the affective events theory. [ABSTRACT FROM AUTHOR]

The rat model of perinatal stress (PRS), in which exposure of pregnant dams to restraint stress reduces maternal behavior, is characterized by a metabolic profile that is reminiscent of the "metabolic syndrome". We aimed to identify plasma metabolomic signatures linked to long-term programming induced by PRS in aged male rats. This study was conducted in the plasma and frontal cortex. We also investigated the reversal effect of postpartum carbetocin (Cbt) on these signatures, along with its impact on deficits in cognitive, social, and exploratory behavior. We found that PRS induced long-lasting changes in biomarkers of secondary bile acid metabolism in the plasma and glutathione metabolism in the frontal cortex. Cbt treatment demonstrated disease-dependent effects by reversing the metabolite alterations. The metabolomic signatures of PRS were associated with long-term cognitive and emotional alterations alongside endocrinological disturbances. Our findings represent the first evidence of how early life stress may alter the metabolomic profile in aged individuals, thereby increasing vulnerability to CNS disorders. This raises the intriguing prospect that the pharmacological activation of oxytocin receptors soon after delivery through the mother may rectify these alterations. [ABSTRACT FROM AUTHOR]

This study delves into the intricate relationship among peace attitudes, personality traits, and sustainable behaviors in a diverse sample of 279 adults from different regions of Italy. Building upon the existing literature, this research affirms the influence of agreeableness, openness, and conscientiousness as primary personality traits associated with sustainable behaviors. Additionally, this study scrutinizes the unique predictive power of peace attitudes. The Peace Attitude Scale (PAS), the Big Five Questionnaire (BFQ), and the Sustainable Behaviors Scale (SBS) were utilized to evaluate peace attitudes, personality traits, and sustainable behaviors. The analysis reveals that peace attitudes significantly predict sustainable behaviors, accounting for 31% of the variance. This predictability is attributed to intrinsic motivation and value alignment. Importantly, peace attitudes extend beyond environmental concerns to embrace social justice and equity, integral components of sustainability. The findings underscore the unique and substantial contribution of peace attitudes to understanding sustainable behavior. This study not only confirms the role of personality traits but also emphasizes the importance of intrinsic values in propelling pro-environmental actions. [ABSTRACT FROM AUTHOR]

Bipolar disorder (BD) is a severe and common chronic mental illness characterized by recurrent mood swings between depression and mania. The biological basis of the disease is poorly understood, and its treatment is unsatisfactory. Na+, K+-ATPase is a major plasma membrane transporter and signal transducer. The catalytic α subunit of this enzyme is the binding site for cardiac steroids. Three α isoforms of the Na+, K+-ATPase are present in the brain. Previous studies have supported the involvement of the Na+, K+-ATPase and endogenous cardiac steroids (ECS) in the etiology of BD. Decreased brain ECS has been found to elicit anti-manic and anti-depressive-like behaviors in mice and rats. However, the identity of the specific α isoform involved in these behavioral effects is unknown. Here, we demonstrated that decreasing ECS through intracerebroventricular (i.c.v.) administration of anti-ouabain antibodies (anti-Ou-Ab) decreased the activity of α1+/− mice in forced swimming tests but did not change the activity in wild type (wt) mice. This treatment also affected exploratory and anxiety behaviors in α1+/− but not wt mice, as measured in open field tests. The i.c.v. administration of anti-Ou-Ab decreased brain ECS and increased brain Na+, K+-ATPase activity in wt and α1+/− mice. The serum ECS was lower in α1+/− than wt mice. In addition, a study in human participants demonstrated that serum ECS significantly decreased after treatment. These results suggest that the Na+, K+-ATPase α1 isoform is involved in depressive- and manic-like behaviors and support that the Na+, K+-ATPase/ECS system participates in the etiology of BD. [ABSTRACT FROM AUTHOR]

The Metaverse technology (MVTECH) is an immersive virtual sphere where people interact with each other via avatars. The MVTECH promised to provide a number of potentials for various sectors including higher education. Despite the fact that MVTECH promotes virtual social interaction between people (e.g., university students), there is a lack of knowledge on what affects users' perceptions regarding its social sustainability in HEIs, specifically in developing nations. Therefore, this research paper aims to determine the variables that affect the learners' perceptions toward social sustainability (SS) of MVTECH in higher educational institutions (HEIs) in Jordan. A study model was formulated by integrating the core factors of the "unified theory of acceptance and use of technology" (UTAUT) ("performance expectancy, PE; effort expectancy, EE; social influence, SI; and facilitating conditions, FC") with "perceived curiosity" (PC) and "extraversion" (EXT) factors. Both PC and EXT were included as context-related variables that may possibly contribute to enhancing the applicability of UTAUT to a wide range of information technologies and settings. Data were collected from 422 students enrolled in Jordanian universities based on an online survey. The analysis of the "structural equation modeling" (SEM) found that students' perceptions toward Metaverse were significantly influenced by PE, FC, and EXT. Furthermore, the PC construct significantly affected the EE construct. However, EE and SI were revealed to have no significant impact on SS. Drawing from these results, the study makes a number of theoretical advances and clarifies a number of practical implications for those involved in the development, design, and decision-making processes that support the use of the Metaverse in HEIs. [ABSTRACT FROM AUTHOR]

A growing amount of research is being conducted on cultural intelligence (CQ), which is the ability to adjust and adapt successfully to a variety of surroundings. CQ is a vital quality for people in diversified societies, as are seen today. However, it is still unclear how an individual can develop or strengthen CQ because previous studies have shown that variables such as foreign experience and personality are not exclusively sufficient as CQ antecedents. If CQ can be treated health-scientifically, as the CQ developers argue, diet and exercise that are effective in keeping the body and brain healthy may also correlate with CQ. It is of great significance to clarify the relationship between lifestyle and CQ by applying recent previous research showing the relationship between CQ and both the brain and intelligence, as well as between lifestyle and both the brain and intelligence. Using data derived from 142 Japanese businesspersons, the results of structural equation modeling indicate that lifestyles (dietary balance and walking frequency) are significantly associated with CQ after controlling for personalities (curiosity and grit) and international experiences (length of studying and working abroad), which have been used as predictors of CQ in previous studies. Furthermore, the moderation test showed that the effect of dietary balance on increasing CQ is greater for people with less overseas experience, indicating that dietary balance compensates for lack of overseas experience in the effect of maintaining the level of CQ. These suggest the effectiveness of a health-scientific approach to the influencing factors of CQ. This study is the first to show that CQ is influenced by lifestyle such as walking and dieting, in addition to personality and overseas experience, and will contribute to the future development of health science and cross-cultural research. [ABSTRACT FROM AUTHOR]

Simple Summary: The spotted paca (Cuniculus paca) has been legally bred by small-scale producers in Brazil as an alternative source of protein. Although captive breeding of this species is considered relatively easy and promising for farmers, little is known about its welfare in captivity. Therefore, using boomer balls to induce object play, we investigated whether object play behavior can be used as a positive emotional state indicator for spotted pacas by examining whether it correlated with other pre-validated positive welfare markers, such as affiliative behavior and low amplitude bark vocalizations. As expected, we found that boomer balls stimulated play. At the same time, the spotted pacas showed more affiliative and exploratory behaviors, with decreased occurrence of agonistic interactions. We also found an increase in barking with low mean amplitude when the paca were provided with boomer balls. Object play behavior thus seems to be a promising non-invasive indicator of positive emotional state in this species because it was associated with an increase in low amplitude barks and more affiliative behavior. As object play can also improve welfare, stimulating its expression, through the provision of boomer balls, should be encouraged on spotted paca farms. We aimed to assess whether object play can be used as a positive emotional state indicator for farmed spotted pacas (Cuniculus paca) by examining its association with other positive welfare markers including affiliative behavior and low-amplitude vocalizations. We submitted six groups of spotted pacas (one male/two females per group) (N = 18) to an ABA experimental design (A1/A2: without ball; B: with three boomer balls). Object play behavior occurred only during phase B (mean = 35.5 s, SE = 6.4). The spotted pacas spent more time in affiliative and exploratory behaviors and less time engaging in agonistic interactions during phase B than in both control phases (A1 and A2) (p < 0.05). Moreover, the spotted pacas emitted more low-amplitude bark vocalizations during phase B than during either control phase (p < 0.05), and such vocalizations have previously been shown to indicate a positive affective state and low arousal level. Because the expression of object play was associated with a decrease in aggression, an increase in affiliative behavior, and an increase in low-amplitude barking, we suggest that object play can be used as a non-invasive indicator of positive emotional state in this species. [ABSTRACT FROM AUTHOR]

This study investigates the therapeutic potential of a new compound, potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (Compound I), in depression. Willner's chronic unpredictable mild stress model of male Wistar rats was used as a depression model. The rats were randomized into four groups, including an intact group, a Compound I group, a Fluoxetine group, and a control group with saline. Behavioral tests, such as the Porsolt forced swim test, hole-board test, elevated plus maze test, and light–dark box, were used to assess the animals' conditions. Our results demonstrated that Compound I effectively reduced the immobilization time of rats in the forced swim test, increased orientation and exploratory behavior, and decreased the latency period of going into the dark compartment compared to the control group. Hippocampal and striatal serotonin concentrations were increased in the Compound I group, and the compound also reduced the level of corticosterone in the blood plasma of rats compared to the intact animals. These results suggest that Compound I has reliable antidepressant activity, comparable to that of the reference antidepressant Fluoxetine. [ABSTRACT FROM AUTHOR]

This study investigated the effects of subchronic arsenic exposure on behavior, neurological function, and hippocampal damage in rats. Thirty-two male Wistar rats were divided into four groups and exposed to different concentrations of arsenic in their drinking water for 12 weeks, while weekly water intake and body weight were recorded. Various neurobehavioral tests were conducted, evaluating overall activity levels, exploratory behavior, short-term memory, spatial learning and memory, anxiety-like behavior, and depressive-like states. Arsenic levels in urine, serum, and brain tissue were measured, and histopathological analysis assessed hippocampal damage using hematoxylin and eosin staining. The results demonstrated that arsenic exposure did not significantly affect overall activity or exploratory behavior. However, it impaired short-term memory and spatial learning and memory functions. Arsenic-exposed rats exhibited increased anxiety-like behavior and a depressive-like state. Arsenic levels increased dose-dependently in urine, serum, and brain tissue. The histopathological examinations revealed significant hippocampal damage, including neuronal shrinkage, cell proliferation, irregular structure, disordered arrangement, and vacuolation. These findings emphasize the importance of understanding the impact of arsenic exposure on behavior and brain health, highlighting its potential neurological consequences. [ABSTRACT FROM AUTHOR]

This study was designed in order to understand the psychological benefits of an indoor smart farm restaurant, which is a restaurant that operates a smart farm inside the restaurant. The study more specifically proposes a conceptual framework that includes psychological benefits, attitudes, and future engagement. In addition, this study investigated whether the impact of psychological benefits on attitude is moderated by curiosity. The data was collected from 317 participants in South Korea. The results revealed that warm glow, nature experiences, and self-expressive benefits positively influenced attitude. Also, attitude, warm glow, and self-expressive benefits significantly affected future engagement. Lastly, the effect of psychological benefits on attitudes is moderated by curiosity. [ABSTRACT FROM AUTHOR]

Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is often refractory to drug therapy. A potential cause of temporal lobe epilepsy is primary brain injury, making prevention of epileptogenesis after the initial event an optimal method of treatment. Despite this, no preventive therapy for epilepsy is currently available. The purpose of this study was to evaluate the effects of anakinra, lamotrigine, and their combination on epileptogenesis using the rat lithium-pilocarpine model of temporal lobe epilepsy. The study showed that there was no significant difference in the number and duration of seizures between treated and untreated animals. However, the severity of seizures was significantly reduced after treatment. Anakinra and lamotrigine, alone or in combination, significantly reduced neuronal loss in the CA1 hippocampus compared to the control group. However, the drugs administered alone were found to be more effective in preventing neuron loss in the hippocampal CA3 field compared to combination treatment. The treatment alleviated the impairments in activity level, exploratory behavior, and anxiety but had a relatively weak effect on TLE-induced impairments in social behavior and memory. The efficacy of the combination treatment did not differ from that of anakinra and lamotrigine monotherapy. These findings suggest that anakinra and lamotrigine, either alone or in combination, may be clinically useful in preventing the development of histopathological and behavioral abnormalities associated with epilepsy. [ABSTRACT FROM AUTHOR]

As the population ages, a high prevalence of multimorbidity will affect the way physicians need to think about drug interactions. With microglia's important involvement in the pathology and progression of Alzheimer's disease (AD), understanding whether systemically administered drugs intended for other affections could impact microglia function, already impacted by the presence of beta-amyloid, is important. The aim of this study was to evaluate morphological changes of microglia, using in vivo 2-photon laser scanning microscopy, in a murine model of AD under systemic administration of sodium or calcium ion channel blockers in order to establish potential effects that these drugs might have on microglia under neuro-inflammatory conditions. A total of 30 mice (age 14–16 weeks, weight 20–25 g) were used, with 25 APP randomly divided into three groups. The remaining animals were CX3CR1GFP/GFP male mice (n = 5) used as WT controls. After baseline behavior testing, all animals received daily intraperitoneal injections for 30 days according to the assigned group [WT (n = 5), Control (n = 5), Carbamazepine (n = 10), and Verapamil (n = 10)]. The results showed that the Verapamil treatment improved short-term memory and enhanced exploratory behavior in APP mice. The Carbamazepine treatment also improved short-term memory but did not elicit significant changes in anxiety-related behavior. Both Verapamil and Carbamazepine reduced the surveillance speed of microglia processes and changed microglia morphology in the cortex compared to the Control group. Due to their complex molecular machinery, microglia are potentially affected by drugs that do not target them specifically, and, as such, investigating these interactions could prove beneficial in our management of neurodegenerative pathologies. [ABSTRACT FROM AUTHOR]

Building upon earlier research, this paper unpacks the complex relationship between punk and Krishna Consciousness, in this instance through the lens of Paulo Freire's notion of praxis. Here, the intersection between punk, the Hare Krishna movement and the corresponding relationship between auto-didacticism and spirituality are examined as a means of interrogating subcultural participation and the hegemonic dominance of the anti-religious sentiment within punk. Freire's approach is examined within the context of this relationship, specifically regarding the inquisitiveness of the individual as they begin the process of engaging with Krishna Consciousness and spirituality, especially from the standpoint of punk. The importance here lies in the learning process being in a state of flux, where the continual re-creation of knowledge and inquiry becomes a means of consolidating the dialectical relationship between the self and the world around it. Here, punk becomes a valuable space in which to discover new ideas, a means of developing an aesthetic and subcultural/religious/spiritual membership within a framework of auto-didacticism; of illuminating the dialectical, hermeneutic relationship between consciousness and the world around us, central to Freire's concept of praxis. [ABSTRACT FROM AUTHOR]

Thermodynamics is an engineering subject that is particularly difficult to teach and learn because it requires strong abstract theoretical concepts and extensive multidisciplinary knowledge. This manuscript introduces mind map learning as an alternative methodology for structuring both the learning and teaching processes in a transparent way for students in the context of thermodynamics. Mind maps help students to learn in a non-linear way promoting out-of-the-box thinking. In a quantitative pre–post study, the student knowledge outcomes were investigated through surveys and compared with the results of a control group. Factor analysis was carried out grouping four principal categories (66% of the total variance): visual insight to create links between pre-existing and new knowledge; motivation, related to curiosity to learn new concepts; applicability and critical thinking. Cronbach's alpha was 0.84, which revealed good internal consistency. The results obtained are explained through constructivist and neuroeducation theories pointing out the relevance of the following concepts: alignment between pre-existing and new knowledge, learning improvement when multisensorial resources are used (like visual forms, font size, colors, hearing, speaking, etc.), and the impact of visual information on brain executive functions. The key to genuine education is curiosity and experience, as well as diving into hands-on learning, asking questions, and experimenting to truly grow. [ABSTRACT FROM AUTHOR]

Valorphin (V1) is a naturally occurring peptide derived from hemoglobin that has been found to have an affinity for opioid receptors and exhibits antinociceptive and anticonvulsant activity. Some of its synthetic analogs containing an aminophosphonate moiety show structure-dependent potent antinociceptive effects. This study aimed to reveal a detailed picture of the antinociceptive mechanisms and behavioral effects of V1 and its recently synthesized phosphopeptide analog V2p in rodents using a range of methods. The studied peptides significantly reduced acute (mean V1–9.0, V2p–5.8 vs. controls–54.1 s) and inflammatory (mean V1–57.9 and V2p–53.3 vs. controls–107.6 s) nociceptive pain in the formalin test, as well as carrageenan-induced hyperalgesia (mean V1–184.7 and V2p–107.3 vs. controls–61.8 g) in the paw pressure test. These effects are mediated by activation of opioid receptors with a predominance of kappa in V1 antinociception and by delta, kappa, and mu receptors in V2p-induced antinociception. Both peptides did not change the levels of TNF-alpha and IL-1-beta in blood serum. V1 induces depression-like behavior, and V2p shows a tendency toward anxiolysis and short-term impairment of motor coordination without affecting exploratory behavior. The results characterize valorphin and its derivative as promising analgesics that exert their effects both centrally and peripherally, without causing severe behavioral changes in experimental animals. These encouraging data are a foundation for future studies focusing on the effects of hemorphins after long-term treatment. [ABSTRACT FROM AUTHOR]

Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible for persistent symptoms are unknown. Here we establish an animal model of long-lasting effects on the brain by eliciting mild disease in K18-hACE2 mice. Male and female K18-hACE2 mice were infected with 4 × 103 TCID50 of SARS-CoV-2 and, following recovery from acute infection, were tested in the open field, zero maze, and Y maze, starting 30 days post infection. Following recovery from SARS-CoV-2 infection, K18-hACE2 mice showed the characteristic lung fibrosis associated with SARS-CoV-2 infection, which correlates with increased expression of the pro-inflammatory kinin B1 receptor (B1R). These mice also had elevated expression of B1R and inflammatory markers in the brain and exhibited behavioral alterations such as elevated anxiety and attenuated exploratory behavior. Our data demonstrate that K18-hACE2 mice exhibit persistent effects of SARS-CoV-2 infection on brain tissue, revealing the potential for using this model of high sensitivity to SARS-CoV-2 to investigate mechanisms contributing to long COVID symptoms in at-risk populations. These results further suggest that elevated B1R expression may drive the long-lasting inflammatory response associated with SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

Is curiosity a virtue or a vice? Curiosity, as a disposition to attain new, worthwhile information, can manifest as an epistemic virtue. When the disposition to attain new information is not manifested virtuously, this is either because the agent lacks the appropriate motivation to attain the information or because the agent has poor judgement, seeking information that is not worthwhile or seeking information by inappropriate means. In the right circumstances, curiosity contributes to the agent's excellence in character: it is appropriate to praise the agent for being curious, blame the agent for not being curious, and also prompt the agent to cultivate such curiosity, at least in some of the relevant contexts. We believe curiosity can also manifest as a moral virtue when it helps an interpreter view a speaker as an agent with a valuable perspective on the world. Especially in interactions where either there is a marked power imbalance between interpreter and speaker, or interpreter and speaker have identity beliefs that lead them to radically different worldviews, curiosity can help foster mutual understanding, and prevent the interpreter from dismissing, marginalizing, or pathologizing the speaker's perspective. [ABSTRACT FROM AUTHOR]

Curiosity's connection with democracy remains neglected and unexplored. Various disciplines have mostly treated curiosity as an epistemic trait of the individual. Beyond epistemology, curiosity is studied as a moral virtue or vice of the self. Beyond epistemic and moral frameworks, curiosity is examined politically and decolonially. However, all frameworks remain focused on the individual and rarely imply a relevance of curiosity to democracy. The present article departs from such explorative frameworks philosophically to expand the research scope on curiosity in the direction of democratic theory. It highlights the complex politics of curiosity as a collective, rather than merely individual, desire for knowledge. I argue that curiosity should become a key analytical category for studying democracy as a political attitude and as a way of life. Investigations of the multifaceted curiosity of the demos may enhance the visibility of ethico-political issues that often escape the curious eye of citizens and researchers. [ABSTRACT FROM AUTHOR]

Simple Summary: Animals differ in their foraging efficiency and it is not clear what drives this variation. We examined how the foraging efficiency of long-billed hermit hummingbirds changes with regard to three behavioral traits: (a) exploration, (b) risk avoidance and (c) arousal in conditions at two different levels of perceived risk (low and high). We found that foraging efficiency was lower in high-risk conditions, but behavioral traits explained the additional variation in foraging efficiency in a condition-dependent manner. More explorative individuals had higher foraging efficiency in low-risk conditions, but the opposite was the case in high-risk conditions. Regardless of the conditions, foraging efficiency increased with bird arousal and decreased if they were more cautious (higher risk avoidance). Our findings highlight the importance of taking into account additional behavioral dimensions to better understand the foraging strategies of individuals. Traditionally, foraging behavior has been explained as the response to a trade-off between energetic gain from feeding resources and potential costs from concomitant risks. However, an increasing number of studies has shown that this view fails to explain an important fraction of the variation in foraging across a variety of taxa. One potential mechanism that may account for this variation is that various behavioral traits associated with foraging may have different fitness consequences, which may depend on the environmental context. Here, we explored this mechanism by evaluating the foraging efficiency of long-billed hermit hummingbirds (Phaethornis longirostris) with regard to three behavioral traits: (a) exploration (number of feeders used during the foraging visit), (b) risk avoidance (latency to start feeding) and (c) arousal (amount of movements during the foraging visit) in conditions at two different levels of perceived risk (low—control and high—experimental, with a threatening bullet ant model). Foraging efficiency decreased in response to threatening conditions. However, behavioral traits explained additional variation in foraging efficiency in a condition-dependent manner. More exploration was associated with a higher foraging efficiency under control conditions, but this was reversed when exposed to a threat. Regardless of the conditions, arousal was positively associated with foraging efficiency, while risk avoidance was negatively related. Importantly, exploratory behavior and risk avoidance were quite repeatable behaviors, suggesting that they may be related to the intrinsic traits of individuals. Our findings highlight the importance of taking into account additional behavioral dimensions to better understand the foraging strategies of individuals. [ABSTRACT FROM AUTHOR]

Curiosity during learning increases information-seeking behaviors and subsequent memory retrieval success, yet the mechanisms that drive curiosity and its accompanying information-seeking behaviors remain elusive. Hints throughout the literature suggest that curiosity may result from a metacognitive signal—possibly of closeness to a not yet accessible piece of information—that in turn leads the experiencer to seek out additional information that will resolve a perceptibly small knowledge gap. We examined whether metacognition sensations thought to signal the likely presence of an as yet unretrieved relevant memory (such as familiarity or déjà vu) might be involved. Across two experiments, when cued recall failed, participants gave higher curiosity ratings during reported déjà vu (Experiment 1) or déjà entendu (Experiment 2), and these states were associated with increased expenditure of limited experimental resources to discover the answer. Participants also spent more time attempting to retrieve information and generated more incorrect information when experiencing these déjà vu-like states than when not. We propose that metacognition signaling of the possible presence of an as yet unretrieved but relevant memory may drive curiosity and prompt information-seeking that includes further search efforts. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive degeneration of the dopaminergic system, leading to a variety of motor and nonmotor symptoms. The currently available symptomatic therapy loses efficacy over time, indicating the need for new therapeutic approaches. Repetitive transcranial magnetic stimulation (rTMS) has emerged as one of the potential candidates for PD therapy. Intermittent theta burst stimulation (iTBS), an excitatory protocol of rTMS, has been shown to be beneficial in several animal models of neurodegeneration, including PD. The aim of this study was to investigate the effects of prolonged iTBS on motor performance and behavior and the possible association with changes in the NMDAR subunit composition in the 6-hydroxydopamine (6-OHDA)-induced experimental model of PD. Two-month-old male Wistar rats were divided into four groups: controls, 6-OHDA rats, 6-OHDA + iTBS protocol (two times/day/three weeks) and the sham group. The therapeutic effect of iTBS was evaluated by examining motor coordination, balance, spontaneous forelimb use, exploratory behavior, anxiety-like, depressive/anhedonic-like behavior and short-term memory, histopathological changes and changes at the molecular level. We demonstrated the positive effects of iTBS at both motor and behavioral levels. In addition, the beneficial effects were reflected in reduced degeneration of dopaminergic neurons and a subsequent increase in the level of DA in the caudoputamen. Finally, iTBS altered protein expression and NMDAR subunit composition, suggesting a sustained effect. Applied early in the disease course, the iTBS protocol may be a promising candidate for early-stage PD therapy, affecting motor and nonmotor deficits. [ABSTRACT FROM AUTHOR]

Numerous noncognitive factors have been shown to influence students' academic and nonacademic outcomes, yet few studies have contemporarily studied these factors to understand their specific roles. The present study tested a model in which five soft skills (i.e., epistemic curiosity, creativity, critical thinking, perseverance, and social awareness) were conceived as personal qualities that influence achievement and general distress through the mediation of four study-related factors (i.e., achievement emotions, self-regulated learning strategies, motivational beliefs, and study resilience). A total of 606 Italian university students (153 males, Mage = 22.74, SDage = 3.72) participated in the study and completed self-report measures of soft skills, study-related factors, and general distress measures; grades were considered for academic achievement. Results showed that all four study-related factors significantly mediated the relationship of soft skills with academic achievement, while only achievement emotions and study resilience emerged as significant mediators between soft skills and general distress. Our findings indicated complex relations between individual factors and students' outcomes due to several factors. The theoretical and practical implications are discussed. [ABSTRACT FROM AUTHOR]

Adhesion molecules play major roles in cell proliferation, migration, survival, neurite outgrowth and synapse formation during nervous system development and in adulthood. The neural cell adhesion molecule L1 contributes to these functions during development and in synapse formation and synaptic plasticity after trauma in adulthood. Mutations of L1 in humans result in L1 syndrome, which is associated with mild-to-severe brain malformations and mental disabilities. Furthermore, mutations in the extracellular domain were shown to cause a severe phenotype more often than mutations in the intracellular domain. To explore the outcome of a mutation in the extracellular domain, we generated mice with disruption of the dibasic sequences RK and KR that localize to position 858RKHSKR863 in the third fibronectin type III domain of murine L1. These mice exhibit alterations in exploratory behavior and enhanced marble burying activity. Mutant mice display higher numbers of caspase 3-positive neurons, a reduced number of principle neurons in the hippocampus, and an enhanced number of glial cells. Experiments suggest that disruption of the dibasic sequence in L1 results in subtle impairments in brain structure and functions leading to obsessive-like behavior in males and reduced anxiety in females. [ABSTRACT FROM AUTHOR]

Over the past decades, 360-degree virtual tours have been used to provide the public access to accurate representations of cultural heritage sites and museums. The COVID-19 pandemic has contributed to a rise in the popularity of virtual tours as a means of engaging with locations remotely and has raised an interesting question: How could we use such experiences to bring the public closer to locations that are otherwise unreachable in real life or not considered to be tourist destinations? In this study, we examine the effectiveness of promoting engagement with a city through the virtual presentation of unknown and possibly also inaccessible points of interest through a 360-degree panoramic virtual tour. The evaluation of the experience with 31 users through an online questionnaire confirms its potential to spark curiosity, promote engagement, foster reflection, and motivate users to explore the location and its attractions at their leisure, thus enabling them to experience it from their personal point of view. The outcomes highlight the need for further research to explore this potential and identify best practices for virtual experience design. [ABSTRACT FROM AUTHOR]

Since the evolution of massive online open courses (MOOCs) as an Ed-Tech solution to various educational problems, learners have registered themselves for various MOOCs offered by various universities and MOOC platforms. However, it has been observed that many learners who register need to complete the course and progress further. Thus, the present research aims to study the learners' lack of continuance of MOOCs. The research is based upon a quantitative research design in which a conceptual model is developed and tested empirically by employing a survey questionnaire as a tool for data collection. The data was collected from 377 respondents who were university students from Saudi Arabia studying at Jazan University, and partial least square-structural equation modeling (PLS-SEM) was used as a tool for data analysis. The results of PLS-SEM show that learner continuance behavior depends on three elements: perceived career success, perceived training opportunity, and satisfaction with MOOCs. The results further show that content vividness, interactivity, and intellectual curiosity are antecedents of satisfaction with MOOCs. The present research has argued that user gratification will yield continuance with technology products. It argues that rational aspects such as career success and acquisition of tangible skills can also yield continuance with technology products and services. [ABSTRACT FROM AUTHOR]

Background: This study aimed to analyse the psychometric properties of the Curiosity and Exploration Inventory-II (CEI-II) to provide evidence of validity for its use in research on health promotion and the quality of life of young Spanish university students. Method: A sample of 807 participants (75.09% female) aged 18–26 years (M = 20.68; SD = 2.13) completed the CEI-II and health and quality of life measures questionnaire. Results: A unidimensional structure was confirmed, but the original two-dimensional structure also showed an adequate fit. The measures obtained from the CEI-II were gender- and age-invariant, which exhibited adequate internal consistency for both the full scale and subscales, and showed a statistically significant relationship with life satisfaction, sense of coherence, and psychological distress. Conclusions: The CEI-II can be used as unidimensional, which is recommended, but also as a two-dimensional measure. Both structures provide reliable, valid, and invariant measures across gender and age of exploratory behaviours in Spanish university students. Furthermore, the results confirm the association between exploratory behaviours and greater health management. [ABSTRACT FROM AUTHOR]

While research has consistently demonstrated how autobiographical memory triggers visual exploration, prior studies did not investigate gender differences in this domain. We thus compared eye movement between women and men while performing an autobiographical retrieval task. We invited 35 women and 35 men to retrieve autobiographical memories while their gaze was monitored by an eye tracker. We further investigated gender differences in eye movement and autobiographical specificity, that is, the ability to retrieve detailed memories. The analysis demonstrated shorter fixations, larger duration and amplitude of saccades, and higher autobiographical specificity in women than in men. The significant gender differences in eye movement disappeared after controlling for autobiographical specificity. When retrieving autobiographical memory, female participants generated a large scan with short fixation and high saccade amplitude, while male participants increased their fixation duration and showed poorer gaze scan. The large saccades in women during autobiographical retrieval may constitute an exploratory gaze behavior enabling better autobiographical memory functioning, which is reflected by the larger number of autobiographical details retrieved compared to men. [ABSTRACT FROM AUTHOR]

Recent studies revealed that grey matter (GM) changes due to various training and learning experiences, using magnetic resonance imaging. In this study, we investigate the effect of psychological characteristics and attitudes toward training and learning on GM changes. Ninety participants were recruited and distributed into three groups: an olfactory training group that underwent 40 olfactory training sessions designed for odour classification tasks, a group classified for learning of neuroplasticity and brain healthcare using a TED Talk video and 28 daily brain healthcare messages, and a control group. Further, we assessed psychological characteristics, such as curiosity and personal growth initiatives. In the olfactory training group, we conducted a questionnaire survey on olfactory training regarding their interests and sense of accomplishment. In the olfactory training group, the GM change was significantly correlated with the sense of achievement and interest in training. The learning of neuroplasticity and brain healthcare group showed a significantly smaller 2-month GM decline than did the control group. The Curiosity and Exploration Inventory-II scores were significantly correlated with GM changes in both intervention groups only. In conclusion, our result suggested that training or learning with a sense of accomplishment, interest, and curiosity would lead to greater GM changes. [ABSTRACT FROM AUTHOR]

E-commerce is the trade of services and goods via electronic means such as the Internet. It is critical in today's business and user experience. Most current e-commerce websites employ various technologies such as recommender systems to provide customers with personalised recommendations. Taking this as a cue, this study investigates the effect of cognitive absorption to estimate the holistic experience of recommender systems on shoppers' intentions to reuse recommender systems. Data collected from 366 online shoppers were analysed using structural equation modelling to test the proposed hypotheses. The findings highlight that cognitive absorption directly and indirectly affects shoppers' behavioural intentions to reuse recommender systems. The results also exposed the moderating effect of gender on shoppers' behavioural intentions to reuse recommender systems. An importance-performance map analysis was also conducted to identify significant areas of improvement for e-vendors. This study contributes to advancing existing knowledge relevant to shoppers' behavioural intentions to reuse recommender systems. The study also provides e-vendor managers with insights into online shoppers' decision making. [ABSTRACT FROM AUTHOR]

Soft skills are the key characteristics for students' success and wellbeing in the 21st century, but they were only rarely studied contemporarily or integrated into comprehensive models of self-regulated learning. This makes it difficult to understand the role that specific skills have above and beyond the others and how they work together to favor students' achievement and life satisfaction. For this reason, in a sample of 585 students (10–18 years old), we applied an exploratory network analysis and studied three crucial soft skills (i.e., adaptability, curiosity, and perseverance) and their contemporary network of inter-relationships with a host of functional study-related factors, including self-regulated learning strategies, motivation, emotions, cognitive abilities, academic achievement, and life and school satisfaction. Results show that the three soft skills play a positive role within the school context through their association with the majority of the study-related factors that mediate their relationships with academic achievement. Importantly, the results differentiated adaptability (which mainly relates with wellbeing and emotional variables), perseverance (which relates with the cognitive and behavioral aspect of learning), and curiosity (which bridges the connection between the other skills and relates with emotional and behavioral variables) in the school context. Overall, these findings contribute to the deepening of the theoretical framework on soft skills and their role as part of a successful learning profile, and inform us about the possible effectiveness of intervention on soft skills for students' achievement and wellbeing. [ABSTRACT FROM AUTHOR]

Simple Summary: Termites are eusocial insects that live in large colonies made up of queens, kings, workers, and soldiers. Queens and kings start new colonies and continually reproduce. Workers are responsible for many crucial roles, including colony husbandry, foraging, and nest construction. Soldiers are adapted for colony defense, usually with large heads and mandibles to ward off predators, but their defensive adaptations prevent them from caring for themselves or performing tasks within the nest. The soldiers of some termite species participate in foraging, either directly by scouting food sources and recruiting workers, or indirectly by influencing worker foraging behavior through their presence. Colonies of the Formosan subterranean termite maintain relatively large soldier proportions compared to termites in their invasive range, but the potential soldier influence on foraging workers has not yet been studied. Since the soldiers of other termite species can influence food exploration, we hypothesized that soldier presence also influences foraging behavior in this species. We compared the exploratory behavior of foraging groups of 100 workers and either 0, 2, 10, or 30 soldiers to determine whether soldier concentration influenced tunnel complexity, tunnel speed, food location, or food collection. In the context of this study, soldier presence did not influence worker foraging behavior, which suggests that workers of the Formosan subterranean termite can maintain foraging efficiency regardless of fluctuations in soldier presence. Termites are eusocial insects that live in organized colonies consisting of reproductives, workers, and soldiers. Soldiers are specialized for defense but are expensive to maintain, as they are incapable of husbandry and must be fed and groomed by workers. The soldiers of several species influence foraging behavior by acting as scouts that initiate foraging or by mediating worker behavioral plasticity during food exploration. These behaviors imply that soldiers may play a keystone role in termite colony function, apart from defense. Subterranean termite workers tunnel through soil in search of food while accompanied by varying proportions of soldiers, depending on the species and colony conditions. Previous studies have shown that soldiers accelerate worker exploratory tunneling behavior in two Reticulitermes species, the colonies of which contain fewer than 2% soldiers. This effect, however, is unknown in other subterranean species with different soldier proportions. In this study, we examined the influence of soldiers on exploratory foraging behavior in the Formosan subterranean termite, Coptotermes formosanus Shiraki, which is an economically devastating invasive species that maintains a relatively high soldier proportion (about 10%). When 100 foraging workers were grouped with 0, 2, 10, or 30 soldiers in two-dimensional foraging arenas, we found no significant effect of soldiers on the tunnel length, branch pattern, food source interception, or food collected within 96 h. These results suggest that C. formosanus colonies maintain food exploration efficiency regardless of soldier proportion variation. [ABSTRACT FROM AUTHOR]

Williams–Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a chromosomic microdeletion (7q11.23). WBS has been modeled by a mouse line having a complete deletion (CD) of the equivalent mouse locus. This model has been largely used to investigate the etiopathological mechanisms of WBS, although pharmacological therapies have not been identified yet. Surprisingly, CD mice were so far mainly tested in adulthood, despite the developmental nature of WBS and the critical relevance of early timing for potential treatments. Here we provide for the first time a phenotypic characterization of CD mice of both sexes during infancy and adolescence, i.e., between birth and 7 weeks of age. CD pups of both sexes showed reduced body growth, delayed sensory development, and altered patterns of ultrasonic vocalizations and exploratory behaviors. Adolescent CD mice showed reduced locomotion and acoustic startle response, and altered social interaction and communication, the latter being more pronounced in female mice. Juvenile CD mutants of both sexes also displayed reduced brain weight, cortical and hippocampal dendritic length, and spine density. Our findings highlight the critical relevance of early neurobehavioral alterations as biomarkers of WBS pathology, underlying the importance of adolescence for identifying novel therapeutic targets for this neurological disorder. [ABSTRACT FROM AUTHOR]

The child is a trust from Allah and the ornament of the worldly life. In the early childhood period, which includes the preschool period, the child asks many questions, wants to understand everything around them, and shows an inexhaustible desire to learn. This research was carried out to examine the opinions of Qur'an course teachers about the religious and moral curiosity of preschool children. A qualitative method was used to ascertain the opinions of 40 participants in 2022. Six themes and 42 codes were determined from the answers provided by the participants to the questions in the semi-structured interview form. A content analysis method with a phenomenology design was used to analyze the data obtained in this study. It was found that children were intensely curious about the religious and moral issues of Allah, the Prophet, angels, death, heaven, hell and prayer; they can ask questions comfortably to satisfy their curiosity, and it was determined that they are excited when asking questions. It was found that teachers reacted positively to satisfy and expand children's curiosity. In addition, we concluded that family and environmental learning are important factors that increase children's curiosity, and activities such as drama, games and experiments conducted by teachers increase children's curiosity. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of nigral dopaminergic neurons. Increasing evidence supports that PD is not simply a motor disorder but a systemic disease leading to motor and non-motor symptoms, including memory loss and neuropsychiatric conditions, with poor management of the non-motor deficits by the existing dopaminergic medication. Oxidative stress is considered a contributing factor for nigrostriatal degeneration, while antioxidant/anti-inflammatory properties of natural phyto-polyphenols have been suggested to have beneficial effects. The present study aimed to determine the contribution of monoaminergic neurotransmission on the anxiety-like phenotype in a rat rotenone PD model and evaluate the possible neuroprotective effects of black Corinthian currant, Vitis vinifera, consisting of antioxidant polyphenols. Rotenone-treated rats showed anxiety-like behavior and exploratory deficits, accompanied by changes in 5-HT, SERT and β2-ARs expression in the prefrontal cortices, hippocampus and basolateral amygdala. Importantly, the motor and non-motor behavior, as well as 5-HT, SERT and β2-ARs expression patterns of the PD-like phenotype were partially recovered by a supplementary diet with currants. Overall, our results suggest that the neuroprotective effects of Corinthian currants in rotenone-induced anxiety-like behavior may be mediated via corticolimbic serotonergic transmission. [ABSTRACT FROM AUTHOR]

Bioprospecting of novel antibiotics has been the conventional norm of research fostered by researchers worldwide to combat drug resistance. With the exhaustion of incessant leads, the search for new chemical entities moves into uncharted territories such as the deep sea. The deep sea is a furthermost ecosystem with much untapped biodiversity thriving under extreme conditions. Accordingly, it also encompasses a vast pool of ancient natural products. Actinobacteria are frequently regarded as the bacteria of research interest due to their inherent antibiotic-producing capabilities. These interesting groups of bacteria occupy diverse ecological habitats including a multitude of different deep-sea habitats. In this review, we provide a recent update on the novel species and compounds of actinomycetes from the deep-sea environments within a period of 2016–2022. Within this period, a total of 24 new species of actinomycetes were discovered and characterized as well as 101 new compounds of various biological activities. The microbial communities of various deep-sea ecosystems are the emerging frontiers of bioprospecting. [ABSTRACT FROM AUTHOR]

The tip-of-the-tongue (TOT) state is a spontaneously occurring metacognitive state that indicates that the answer to a query is almost, but not quite, at hand, i.e., that resolution is imminent. Since the time of William James, a distinctive feeling of nagging frustration has been observed to be associated with TOT states. On a more positive note, TOT states are also associated with intense goal-directed curiosity and with a strong desire to know that translates into successful mental action. The present study showed that prior to the presentation of resolving feedback to verbal queries—if the individual was in a TOT state—alpha suppression was in evidence in the EEG. This alpha suppression appears to be a marker of a spontaneously occurring, conscious, and highly motivating goal-directed internal metacognitive state. At the same time, alpha expression in the same time period was associated with the feeling of not knowing, indicating a more discursive state. Both alpha and alpha suppression were observed broadly across centro-parietal scalp electrodes and disappeared immediately upon presentation of the resolving feedback. Analyses indicated that the occurrence of alpha suppression was associated with participants' verbal affirmations of being in a TOT state, which is also related to subsequent expression of a late positivity when feedback is provided, and to enhanced memory. [ABSTRACT FROM AUTHOR]

The study of curiosity as a construct has led to many conceptualisations, comprising of different dimensions. Due to this, various scales of curiosity have also been developed. Moreover, some researchers have conceived of curiosity as a general trait-like, while others have included contexts, such as the workplace, or education when investigating curiosity. This scoping review aims to scope the extant psychological literature on curiosity in order to better understand how it has been studied, specifically with regard to its dimensions, measures, and contexts. A total of 1194 records were identified, with 245 articles meeting the inclusion criteria. Results suggest that the majority of curiosity research examined curiosity as having multiple dimensions and analysed the dimensions individually, with a deprivation-type curiosity playing the biggest role. The measure most commonly used was the Epistemic Curiosity Scale, which also consisted of a deprivation-type curiosity as one of the dimensions. Findings also implied that curiosity was most studied in the context of the workplace. Supplementary findings included a lack of representation of non-Western countries, as well as needing to cross-validate a recently developed curiosity scale. This scoping review represents a consolidation of the curiosity literature and how it can further prosper. [ABSTRACT FROM AUTHOR]