1. Rho GTPases Signaling in Zebrafish Development and Disease
- Author
-
Marie-José Boueid, Emilie Lesport, Aya Mikdache, Cindy Degerny, and Marcel Tawk
- Subjects
rac1 GTP-Binding Protein ,rho GTP-Binding Proteins ,RHOA ,Cell ,Disease ,CDC42 ,Review ,small GTPases ,Cell Movement ,medicine ,Animals ,Regeneration ,Cdc42 ,GEF ,cdc42 GTP-Binding Protein ,lcsh:QH301-705.5 ,Zebrafish ,Organism ,biology ,Rho GTPases ,RhoA ,GAP ,General Medicine ,Zebrafish Proteins ,biology.organism_classification ,zebrafish ,Cell biology ,Rac ,medicine.anatomical_structure ,lcsh:Biology (General) ,biology.protein ,rhoA GTP-Binding Protein ,Intracellular ,Signal Transduction - Abstract
Cells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review our knowledge on how zebrafish helped us understand the role of some of these proteins in a multitude of in vivo cellular behaviors. Zebrafish studies offer a unique opportunity to explore the role and more specifically the spatial and temporal dynamic of Rho GTPases activities within a complex environment at a level of details unachievable in any other vertebrate organism.
- Published
- 2020