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1. Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Ingeniería Química, Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Universidad de Sevilla, Mehdi-Sefiani, Hanaa, Pérez-Puyana, Víctor Manuel, Ostos Marcos, Francisco José, Sepúlveda Ferrer, Ranier Enrique, Romero García, Alberto, Rafii-El-Idrissi Benhnia, Mohammed, Chicardi Augusto, Ernesto, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Ingeniería Química, Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Universidad de Sevilla, Mehdi-Sefiani, Hanaa, Pérez-Puyana, Víctor Manuel, Ostos Marcos, Francisco José, Sepúlveda Ferrer, Ranier Enrique, Romero García, Alberto, Rafii-El-Idrissi Benhnia, Mohammed, and Chicardi Augusto, Ernesto

Abstract

A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. In addition, the kinetic behaviour was studied for both infiltration and degradation-release processes. A higher infiltration rate was observed in the Ti60 foam. The maximum infiltration hydrogel was achieved for the Ti30 and Ti60 foams after 120 min and 75 min, respectively. Further, both processes followed a Lucas-Washburn theoretical behaviour, typical for the infiltration of a fluid by capillarity in porous channels. Regarding the subsequent degradation-release process, both systems showed similar exponential degradation performance, with the full release from Ti60 foam (80 min), versus 45 min for Ti30, due to the greater interconnected porosity open to the surface of the Ti60 foam in comparison with the Ti30 foam. In addition, the optimal biocompatibility of the hydrogel was confirmed, with the total absence of cytotoxicity and the promotion of cell growth in the fibroblast cells evaluated.

Published
2023

2. Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery

Author

Mehdi-Sefiani, Hanaa, Pérez-Puyana, Víctor Manuel, Ostos Marcos, Francisco José, Sepúlveda Ferrer, Ranier Enrique, Romero García, Alberto, Rafii-El-Idrissi Benhnia, Mohammed, Chicardi Augusto, Ernesto, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Ingeniería Química, Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología, and Universidad de Sevilla

Subjects
Degradation rate, Hydrogel, Porous titanium, Infiltration, Gelatin, Solid foams
Abstract

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. In addition, the kinetic behaviour was studied for both infiltration and degradation-release processes. A higher infiltration rate was observed in the Ti60 foam. The maximum infiltration hydrogel was achieved for the Ti30 and Ti60 foams after 120 min and 75 min, respectively. Further, both processes followed a Lucas-Washburn theoretical behaviour, typical for the infiltration of a fluid by capillarity in porous channels. Regarding the subsequent degradation-release process, both systems showed similar exponential degradation performance, with the full release from Ti60 foam (80 min), versus 45 min for Ti30, due to the greater interconnected porosity open to the surface of the Ti60 foam in comparison with the Ti30 foam. In addition, the optimal biocompatibility of the hydrogel was confirmed, with the total absence of cytotoxicity and the promotion of cell growth in the fibroblast cells evaluated.

Published
2023

3. Synthesis and Characterization of a Nearly Single Bulk Ti2AlN MAX Phase Obtained from Ti/AlN Powder Mixture through Spark Plasma Sintering

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Física de la Materia Condensada, Salvo, Christopher, Chicardi Augusto, Ernesto, Poyato, Rosalía, García-Garrido, Cristina, Jiménez, José Antonio, López Pernía, Cristina, Tobosque, Pablo, Mangalaraja, Ramalinga Viswanathan, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Física de la Materia Condensada, Salvo, Christopher, Chicardi Augusto, Ernesto, Poyato, Rosalía, García-Garrido, Cristina, Jiménez, José Antonio, López Pernía, Cristina, Tobosque, Pablo, and Mangalaraja, Ramalinga Viswanathan

Published
2021

4. Study of the Influence of Sintering Atmosphere and Mechanical Activation on the Synthesis of Bulk Ti2AlN MAX Phase Obtained by Spark Plasma Sintering

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla, Salvo, Christopher, Chicardi Augusto, Ernesto, García Garrido, Cristina, Poyato Galán, Rosalía, Jiménez, José A., Viswanathan Mangalaraja, Ramalinga, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla, Salvo, Christopher, Chicardi Augusto, Ernesto, García Garrido, Cristina, Poyato Galán, Rosalía, Jiménez, José A., and Viswanathan Mangalaraja, Ramalinga

Abstract

The influence of the mechanical activation process and sintering atmosphere on the microstructure and mechanical properties of bulk Ti2AlN has been investigated. The mixture of Ti and AlN powders was prepared in a 1:2 molar ratio, and a part of this powder mixture was subjected to a mechanical activation process under an argon atmosphere for 10 h using agate jars and balls as milling media. Then, the sintering and production of the Ti2AlN MAX phase were carried out by Spark Plasma Sintering under 30 MPa with vacuum or nitrogen atmospheres and at 1200 °C for 10 min. The crystal structure and microstructure of consolidated samples were characterized by X-ray Diffraction, Scanning Electron Microscopy, and Energy Dispersive X-ray Spectroscopy. The X-ray diffraction patterns were fitted using the Rietveld refinement for phase quantification and determined their most critical microstructural parameters. It was determined that by using nitrogen as a sintering atmosphere, Ti4AlN3 MAX phase and TiN were increased at the expense of the Ti2AlN. In the samples prepared from the activated powders, secondary phases like Ti5Si3 and Al2O3 were formed. However, the higher densification level presented in the sample produced by using both nitrogen atmosphere and MAP powder mixture is remarkable. Moreover, the high-purity Ti2AlN zone of the MAX-1200 presented a hardness of 4.3 GPa, and the rest of the samples exhibited slightly smaller hardness values (4.1, 4.0, and 4.2 GPa, respectively) which are matched with the higher porosity observed on the SEM images.

Published
2021

5. Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, Montoya García, María José, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, and Montoya García, María José

Abstract

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

Published
2021

6. Use of Impedance Spectroscopy for the Characterization of In-Vitro Osteoblast Cell Response in Porous Titanium Bone Implants

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Tecnología Electrónica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TIC178: Diseño y Test de Circuitos Integrados de Señal Mixta, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Giner García, Mercedes, Olmo Fernández, Alberto, Hernández, Miguel, Trueba Muñoz, Paloma, Chicardi Augusto, Ernesto, Civantos, Ana, Vázquez Gámez, María de los Ángeles, Montoya García, María José, Torres Hernández, Yadir, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Tecnología Electrónica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TIC178: Diseño y Test de Circuitos Integrados de Señal Mixta, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Giner García, Mercedes, Olmo Fernández, Alberto, Hernández, Miguel, Trueba Muñoz, Paloma, Chicardi Augusto, Ernesto, Civantos, Ana, Vázquez Gámez, María de los Ángeles, Montoya García, María José, and Torres Hernández, Yadir

Published
2020

7. Influence of the Test Configuration and Temperature on the Mechanical Behaviour of WC-Co

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Junta de Andalucía, González, Luis Manuel, Chicardi Augusto, Ernesto, Gotor, F.J., Bermejo, Raúl, Llanes, Luis, Torres Hernández, Yadir, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Junta de Andalucía, González, Luis Manuel, Chicardi Augusto, Ernesto, Gotor, F.J., Bermejo, Raúl, Llanes, Luis, and Torres Hernández, Yadir

Abstract

In this work, the effect of the test configuration and temperature on the mechanical behaviour of cemented carbides (WC-Co) with different carbide grain sizes (dWC) and cobalt volume fractions (VCo), implying different binder mean free paths ( Co), was studied. The mechanical strength was measured at 600º C with bar-shaped specimens subjected to uniaxial four-point bending (4PB) tests and with disc specimens subjected to biaxial ball-on-three-balls (B3B) tests. The results were analysed within the frame of theWeibull theory and compared with strength measurements performed at room temperature under the same loading conditions. A mechanical degradation greater than 30% was observed when the samples were tested at 600ºC due to oxidation phenomena, but higherWeibull moduli were obtained as a result of narrower defect size distributions. A fractographic analysis was conducted with broken specimens from each test configuration. The number of fragments (Nf) and the macroscopic fracture surface were related to the flexural strength and fracture toughness of WC-Co. For a given number of fragments, higher mechanical strength values were always obtained for WC-Co grades with higher KIc. The observed differences were discussed based on a linear elastic fracture mechanics (LEFM) model, taking into account the effect of the temperature and microstructure of the cemented carbides on the mechanical strength.

Published
2020

8. Characterization and Monitoring of Titanium Bone Implants with Impedance Spectroscopy

Author

Universidad de Sevilla. Departamento de Tecnología Electrónica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. TIC178: Diseño y Test de Circuitos Integrados de Señal Mixta, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Olmo Fernández, Alberto, Hernández, Miguel, Chicardi Augusto, Ernesto, Torres Hernández, Yadir, Universidad de Sevilla. Departamento de Tecnología Electrónica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. TIC178: Diseño y Test de Circuitos Integrados de Señal Mixta, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Olmo Fernández, Alberto, Hernández, Miguel, Chicardi Augusto, Ernesto, and Torres Hernández, Yadir

Abstract

Porous titanium is a metallic biomaterial with good properties for the clinical repair of cortical bone tissue, although the presence of pores can compromise its mechanical behavior and clinical use. It is therefore necessary to characterize the implant pore size and distribution in a suitable way. In this work, we explore the new use of electrical impedance spectroscopy for the characterization and monitoring of titanium bone implants. Electrical impedance spectroscopy has been used as a non-invasive route to characterize the volumetric porosity percentage (30%, 40%, 50% and 60%) and the range of pore size (100–200 and 355–500 mm) of porous titanium samples obtained with the space-holder technique. Impedance spectroscopy is proved to be an appropriate technique to characterize the level of porosity of the titanium samples and pore size, in an affordable and non-invasive way. The technique could also be used in smart implants to detect changes in the service life of the material, such as the appearance of fractures, the adhesion of osteoblasts and bacteria, or the formation of bone tissue.

Published
2020

9. Development of a TiNbTaMoZr-Based High Entropy Alloy with Low Young´s Modulus by Mechanical Alloying Route

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Física de la Materia Condensada, Universidad de Sevilla, Normand, Juliette, Moriche Tirado, Rocío, García Garrido, Cristina, Sepúlveda Ferrer, Ranier Enrique, Chicardi Augusto, Ernesto, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Física de la Materia Condensada, Universidad de Sevilla, Normand, Juliette, Moriche Tirado, Rocío, García Garrido, Cristina, Sepúlveda Ferrer, Ranier Enrique, and Chicardi Augusto, Ernesto

Abstract

In this work, an equiatomic TiNbTaMoZr-based high-entropy alloy (HEA) has been developed by a powder metallurgy route, which consists of a process of combined one-step low-temperature mechanical milling starting from the transition metals as raw materials and a subsequent pressureless sintering. In this way, the optimized synthesized specimen, after 10 h of milling time, showed two di erent body-centered cubic (bcc) TiNbTaMoZr alloys, which, after sintering at 1450 C, 1 h of dwell time and a heating and cooling rate of 5 C min-1, it remained formed as two bcc TiNbTaMoZr-based HEAs. This material, with micrometric and equiaxed particles, and with homogeneously distributed phases, presented a Young’s modulus that was significantly higher (5.8 GPa) and lower (62.1 GPa) than that of the usual commercially pure (cp) Ti and Ti6Al4V alloy used for bone-replacement implants. It also presented similar values to those of the HEAs developed for the same purpose. These interesting properties would enable this TiNbTaMoZr-based HEA to be used as a potential biomaterial for bulk or porous bone implants with high hardness and low Young´s modulus, thereby preventing the appearance of stress-shielding phenomena

Published
2020

10. Study of the Effect of the Floating Die Compaction on Mechanical Properties of Titanium Foams

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT). Chile, Fondo de Equipamiento Científico y Tecnológico (FONDEQUIP). Chile, Sauceda, Sergio, Lascano, Sheila, Béjar, Luis, Neves, Guilherme Oliveira, Chicardi Augusto, Ernesto, Salvo, Christopher, Aguilar, Claudio, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT). Chile, Fondo de Equipamiento Científico y Tecnológico (FONDEQUIP). Chile, Sauceda, Sergio, Lascano, Sheila, Béjar, Luis, Neves, Guilherme Oliveira, Chicardi Augusto, Ernesto, Salvo, Christopher, and Aguilar, Claudio

Abstract

Titanium (Ti) and its alloys are used for biomedical applications because of their high resistance to corrosion, good strength-to-weight ratio, and high fatigue resistance. However, a problem that compromises the performance of the material is the mismatch between Young’s modulus of Ti and the bone, which brings about stress shielding. One strategy that has been investigated to reduce this di erence is the manufacture of Ti-based foams, using powder metallurgy (PM) methods, such as the space-holder technique. However, in the uniaxial compaction, both non-uniform density distribution and mechanical properties remain because of the compaction method. This work studies the influence of compaction by adopting a floating-action die related to a single-action die (SAD), on the density of green and sintered Ti foams with porosities around 50 vol.% characterized by optical microscopy, ultrasound analysis, compression tests, and microhardness. The compaction process employing a floating-action die generates Ti foams with a higher density up to 10% with more control of the spacer particle added compared to the single-action die. Furthermore, compaction method has no relevant e ect on microhardness and Young’s modulus, which allows getting better consolidated samples with elastic modules similar to those of human bone.

Published
2020

11. Effects of Boron Addition on the Microstructure and Mechanical Properties of (Ti,Ta)(C,N)-Co Based Cermets

Author

Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Chicardi Augusto, Ernesto, Gotor Martínez, Francisco José, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Chicardi Augusto, Ernesto, and Gotor Martínez, Francisco José

Abstract

In this work, a titanium–tantalum carbonitride based cermet, with cobalt as the binder phase and boron as a sintering additive, was developed by a mechanically induced self-sustaining reaction process using two different methodologies. The boron additive was added to prevent the formation of brittle intermetallic compounds generally formed during the liquid phase sintering step due to the excessive ceramic dissolution into the molten binder phase. A systematic study was carried out to understand the effects of boron addition on the nature of the phases, microstructure, and mechanical properties of cermets. With the boron addition, the formation of two different boride solid solutions, i.e., (Ti,Ta)B2 and (Ti,Ta)3B4, was observed. Moreover, the nature of the binder was also modified, from the (Ti,Ta)Co2 brittle intermetallic compound (for cermets without boron addition) to ductile and tough (Ti,Ta)Co3 and -Co phases (for cermets with boron addition). These modifications caused, as a general trend, the increase of hardness and toughness in cermets.

Published
2019

12. Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, Montoya García, María José, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, and Montoya García, María José

Abstract

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

13. Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, Montoya García, María José, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, and Montoya García, María José

Abstract

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

14. Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, Montoya García, María José, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, and Montoya García, María José

Abstract

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

15. Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, Montoya García, María José, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, and Montoya García, María José

Abstract

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

16. Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, Montoya García, María José, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS211: Metabolismo Cálcico, Hipertensión y Arteriosclerosis, Universidad de Sevilla. TEP973: Tecnología de Polvos y Corrosión, Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales, Giner García, Mercedes, Chicardi Augusto, Ernesto, Costa Martins, Alzenira de Fátima, Santana, Laura, Vázquez Gámez, María de los Ángeles, García Garrido, Cristina, Colmenero, Miguel Ángel, Olmo-Montes, Francisco Jesús, Torres Hernández, Yadir, and Montoya García, María José

Abstract

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

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