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Radar jamming recognition is a key step in electronic countermeasures, and accurate and sufficient labeled samples are essential for supervised learning-based recognition methods. However, in real practice, collected radar jamming samples often have weak labels (i.e., noisy-labeled or unlabeled ones), which degrade recognition performance. Additionally, recognition performance is hindered by limitations in capturing the global features of radar jamming. The Transformer (TR) has advantages in modeling long-range relationships. Therefore, a weakly supervised Transformer is proposed to address the issues of performance degradation under weak supervision. Specifically, complementary label (CL) TR, called RadarCL-TR, is proposed to improve radar jamming recognition accuracy with noisy samples. CL learning and a cleansing module are successively utilized to detect and remove potentially noisy samples. Thus, the adverse influence of noisy samples is mitigated. Additionally, semi-supervised learning (SSL) TR, called RadarSSL-PL-TR, is proposed to boost recognition performance under unlabeled samples via pseudo labels (PLs). Network generalization is improved by training with pseudo-labeling unlabeled samples. Moreover, the RadarSSL-PL-S-TR is proposed to further promote recognition performance, where a selection module identifies reliable pseudo-labeling samples. The experimental results show that the proposed RadarCL-TR and RadarSSL-PL-S-TR outperform comparison methods in recognition accuracy by at least 7.07 % and 6.17 % with noisy and unlabeled samples, respectively. [ABSTRACT FROM AUTHOR]

Recently, transformer has gradually attracted interest for its excellence in modeling the long-range dependencies of spatial-spectral features in HSI. However, transformer has the problem of the quadratic computational complexity due to the self-attention mechanism, which is heavier than other models and thus has limited adoption in HSI processing. Fortunately, the recently emerging state space model-based Mamba shows great computational efficiency while achieving the modeling power of transformers. Therefore, in this paper, we first proposed spectral-spatial Mamba (SS-Mamba) for HSI classification. Specifically, SS-Mamba mainly includes a spectral-spatial token generation module and several stacked spectral-spatial Mamba blocks. Firstly, the token generation module converts any given HSI cube to spatial and spectral tokens as sequences. And then these tokens are sent to stacked spectral-spatial mamba blocks (SS-MB). Each SS-MB includes two basic mamba blocks and a spectral-spatial feature enhancement module. The spatial and spectral tokens are processed separately by the two basic mamba blocks, correspondingly. Moreover, the feature enhancement module modulates spatial and spectral tokens using HSI sample's center region information. Therefore, the spectral and spatial tokens cooperate with each other and achieve information fusion within each block. The experimental results conducted on widely used HSI datasets reveal that the proposed SS-Mamba requires less processing time compared with transformer. The Mamba-based method thus opens a new window for HSI classification. [ABSTRACT FROM AUTHOR]

Background: Current artificial intelligence (AI) in histopathology typically specializes on a single task, resulting in a heavy workload of collecting and labeling a sufficient number of images for each type of cancer. Heterogeneous transfer learning (HTL) is expected to alleviate the data bottlenecks and establish models with performance comparable to supervised learning (SL). Methods: An accurate source domain model was trained using 28,634 colorectal patches. Additionally, 1000 sentinel lymph node patches and 1008 breast patches were used to train two target domain models. The feature distribution difference between sentinel lymph node metastasis or breast cancer and CRC was reduced by heterogeneous domain adaptation, and the maximum mean difference between subdomains was used for knowledge transfer to achieve accurate classification across multiple cancers. Result: HTL on 1000 sentinel lymph node patches (L-HTL-1000) outperforms SL on 1000 sentinel lymph node patches (L-SL-1-1000) (average area under the curve (AUC) and standard deviation of L-HTL-1000 vs. L-SL-1-1000: 0.949 ± 0.004 vs. 0.931 ± 0.008, p value = 0.008). There is no significant difference between L-HTL-1000 and SL on 7104 patches (L-SL-2-7104) (0.949 ± 0.004 vs. 0.948 ± 0.008, p value = 0.742). Similar results are observed for breast cancer. B-HTL-1008 vs. B-SL-1-1008: 0.962 ± 0.017 vs. 0.943 ± 0.018, p value = 0.008; B-HTL-1008 vs. B-SL-2-5232: 0.962 ± 0.017 vs. 0.951 ± 0.023, p value = 0.148. Conclusions: HTL is capable of building accurate AI models for similar cancers using a small amount of data based on a large dataset for a certain type of cancer. HTL holds great promise for accelerating the development of AI in histopathology. [ABSTRACT FROM AUTHOR]

First-line treatment for osteosarcoma includes chemotherapy and surgery. However, the five-year survival rate of refractory osteosarcoma remains unsatisfactory. Osteosarcoma cancer stem cells, possessing stemness and chemoresistance, are one of the critical causes of poor response to chemotherapy. Elucidating regulatory signaling pathways of osteosarcoma cancer stem cells may provide a rationale for improving regimens against chemoresistant osteosarcoma. Methotrexate (MTX)-resistant osteosarcoma cells were established. microRNA expression profiles were used for detecting differentially expressed microRNA in resistant clones and the parental cells. microRNA target databases were employed to predict potential microRNA and mRNA interactions. Flow cytometry was performed to measure stem cell marker Prominin-1 (CD133)-positive cells. Immunofluorescence staining was applied to detect CD133 expression. miR-197-3p mimic or anti-miR-197-3p stably transfected cells were used to generate xenograft models. In the study, we found that miR-197-3p was increased in MTX-resistant cell lines. Overexpression of miR-197-3p enhanced the expression of cancer stem cell markers CD133, Octamer-binding protein 4 (OCT4), Transcription factor SOX-2 (SOX2), and Homeobox protein NANOG (NANOG), as well as chemoresistance-associated genes ATP-dependent translocase ABCB1 (ABCB1) and Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2), whereas miR-197-3p knockdown inhibited stemness and recovered sensitivity to MTX. We also classified the tumor suppressor Speckle-type POZ protein-like (SPOPL) as a target of miR-197-3p. The miR-197-3p mutation that could not combine SPOPL promoter regions was unable to sustain stemness or chemoresistance. Collectively, we discovered miR-197-3p conferred osteosarcoma stemness and chemotherapy resistance by targeting SPOPL, prompting promising therapeutic candidates for refractory osteosarcoma treatment. [ABSTRACT FROM AUTHOR]

Recently, deep learning methods, especially convolutional neural networks (CNNs), have achieved good performance for hyperspectral image (HSI) classification. However, due to limited training samples of HSIs and the high volume of trainable parameters in deep models, training deep CNN-based models is still a challenge. To address this issue, this study investigates contrastive learning (CL) as a pre-training strategy for HSI classification. Specifically, a supervised contrastive learning (SCL) framework, which pre-trains a feature encoder using an arbitrary number of positive and negative samples in a pair-wise optimization perspective, is proposed. Additionally, three techniques for better generalization in the case of limited training samples are explored in the proposed SCL framework. First, a spatial–spectral HSI data augmentation method, which is composed of multiscale and 3D random occlusion, is designed to generate diverse views for each HSI sample. Second, the features of the augmented views are stored in a queue during training, which enriches the positives and negatives in a mini-batch and thus leads to better convergence. Third, a multi-level similarity regularization method (MSR) combined with SCL (SCL–MSR) is proposed to regularize the similarities of the data pairs. After pre-training, a fully connected layer is combined with the pre-trained encoder to form a new network, which is then fine-tuned for final classification. The proposed methods (SCL and SCL–MSR) are evaluated on four widely used hyperspectral datasets: Indian Pines, Pavia University, Houston, and Chikusei. The experiment results show that the proposed SCL-based methods provide competitive classification accuracy compared to the state-of-the-art methods. [ABSTRACT FROM AUTHOR]

Object detection in remote-sensing images (RSIs) is always a vibrant research topic in the remote-sensing community. Recently, deep-convolutional-neural-network (CNN)-based methods, including region-CNN-based and You-Only-Look-Once-based methods, have become the de-facto standard for RSI object detection. CNNs are good at local feature extraction but they have limitations in capturing global features. However, the attention-based transformer can obtain the relationships of RSI at a long distance. Therefore, the Transformer for Remote-Sensing Object detection (TRD) is investigated in this study. Specifically, the proposed TRD is a combination of a CNN and a multiple-layer Transformer with encoders and decoders. To detect objects from RSIs, a modified Transformer is designed to aggregate features of global spatial positions on multiple scales and model the interactions between pairwise instances. Then, due to the fact that the source data set (e.g., ImageNet) and the target data set (i.e., RSI data set) are quite different, to reduce the difference between the data sets, the TRD with the transferring CNN (T-TRD) based on the attention mechanism is proposed to adjust the pre-trained model for better RSI object detection. Because the training of the Transformer always needs abundant, well-annotated training samples, and the number of training samples for RSI object detection is usually limited, in order to avoid overfitting, data augmentation is combined with a Transformer to improve the detection performance of RSI. The proposed T-TRD with data augmentation (T-TRD-DA) is tested on the two widely-used data sets (i.e., NWPU VHR-10 and DIOR) and the experimental results reveal that the proposed models provide competitive results (i.e., centuple mean average precision of 87.9 and 66.8 with at most 5.9 and 2.4 higher than the comparison methods on the NWPU VHR-10 and the DIOR data sets, respectively) compared to the competitive benchmark methods, which shows that the Transformer-based method opens a new window for RSI object detection. [ABSTRACT FROM AUTHOR]

In recent years, supervised learning-based methods have achieved excellent performance for hyperspectral image (HSI) classification. However, the collection of training samples with labels is not only costly but also time-consuming. This fact usually causes the existence of weak supervision, including incorrect supervision where mislabeled samples exist and incomplete supervision where unlabeled samples exist. Focusing on the inaccurate supervision and incomplete supervision, the weakly supervised classification of HSI is investigated in this paper. For inaccurate supervision, complementary learning (CL) is firstly introduced for HSI classification. Then, a new method, which is based on selective CL and convolutional neural network (SeCL-CNN), is proposed for classification with noisy labels. For incomplete supervision, a data augmentation-based method, which combines mixup and Pseudo-Label (Mix-PL) is proposed. And then, a classification method, which combines Mix-PL and CL (Mix-PL-CL), is designed aiming at better semi-supervised classification capacity of HSI. The proposed weakly supervised methods are evaluated on three widely-used hyperspectral datasets (i.e., Indian Pines, Houston, and Salinas datasets). The obtained results reveal that the proposed methods provide competitive results compared to the state-of-the-art methods. For inaccurate supervision, the proposed SeCL-CNN has outperformed the state-of-the-art method (i.e., SSDP-CNN) by 0.92%, 1.84%, and 1.75% in terms of OA on the three datasets, when the noise ratio is 30%. And for incomplete supervision, the proposed Mix-PL-CL has outperformed the state-of-the-art method (i.e., AROC-DP) by 1.03%, 0.70%, and 0.82% in terms of OA on the three datasets, with 25 training samples per class. [ABSTRACT FROM AUTHOR]

Recently, many convolutional neural network (CNN)-based methods have been proposed to tackle the classification task of hyperspectral images (HSI). In fact, CNN has become the de-facto standard for HSI classification. It seems that the traditional neural networks such as multi-layer perceptron (MLP) are not competitive for HSI classification. However, in this study, we try to prove that the MLP can achieve good classification performance of HSI if it is properly designed and improved. The proposed Modified-MLP for HSI classification contains two special parts: spectral–spatial feature mapping and spectral–spatial information mixing. Specifically, for spectral–spatial feature mapping, each input sample of HSI is divided into a sequence of 3D patches with fixed length and then a linear layer is used to map the 3D patches to spectral–spatial features. For spectral–spatial information mixing, all the spectral–spatial features within a single sample are feed into the solely MLP architecture to model the spectral–spatial information across patches for following HSI classification. Furthermore, to obtain the abundant spectral–spatial information with different scales, Multiscale-MLP is proposed to aggregate neighboring patches with multiscale shapes for acquiring abundant spectral–spatial information. In addition, the Soft-MLP is proposed to further enhance the classification performance by applying soft split operation, which flexibly capture the global relations of patches at different positions in the input HSI sample. Finally, label smoothing is introduced to mitigate the overfitting problem in the Soft-MLP (Soft-MLP-L), which greatly improves the classification performance of MLP-based method. The proposed Modified-MLP, Multiscale-MLP, Soft-MLP, and Soft-MLP-L are tested on the three widely used hyperspectral datasets. The proposed Soft-MLP-L leads to the highest OA, which outperforms CNN by 5.76%, 2.55%, and 2.5% on the Salinas, Pavia, and Indian Pines datasets, respectively. The obtained results reveal that the proposed models provide competitive results compared to the state-of-the-art methods, which shows that the MLP-based methods are still competitive for HSI classification. [ABSTRACT FROM AUTHOR]

Jamming is a big threat to the survival of a radar system. Therefore, the recognition of radar jamming signal type is a part of radar countermeasure. Recently, convolutional neural networks (CNNs) have shown their effectiveness in radar signal processing, including jamming signal recognition. However, most of existing CNN methods do not regard radar jamming as a complex value signal. In this study, a complex-valued CNN (CV-CNN) is investigated to fully explore the inherent characteristics of a radar jamming signal, and we find that we can obtain better recognition accuracy using this method compared with a real-valued CNN (RV-CNN). CV-CNNs contain more parameters, which need more inference time. To reduce the parameter redundancy and speed up the recognition time, a fast CV-CNN (F-CV-CNN), which is based on pruning, is proposed for radar jamming signal fast recognition. The experimental results show that the CV-CNN and F-CV-CNN methods obtain good recognition performance in terms of accuracy and speed. The proposed methods open a new window for future research, which shows a huge potential of CV-CNN-based methods for radar signal processing. [ABSTRACT FROM AUTHOR]

In recent years, many convolutional neural network (CNN)-based methods have been proposed to address the scene classification tasks of remote sensing images. Since the number of training samples in RS datasets is generally small, data augmentation is often used to expand the training set. It is, however, not appropriate when original data augmentation methods keep the label and change the content of the image at the same time. In this study, label augmentation (LA) is presented to fully utilize the training set by assigning a joint label to each generated image, which considers the label and data augmentation at the same time. Moreover, the output of images obtained by different data augmentation is aggregated in the test process. However, the augmented samples increase the intra-class diversity of the training set, which is a challenge to complete the following classification process. To address the above issue and further improve classification accuracy, Kullback–Leibler divergence (KL) is used to constrain the output distribution of two training samples with the same scene category to generate a consistent output distribution. Extensive experiments were conducted on widely-used UCM, AID and NWPU datasets. The proposed method can surpass the other state-of-the-art methods in terms of classification accuracy. For example, on the challenging NWPU dataset, competitive overall accuracy (i.e., 91.05%) is obtained with a 10% training ratio. [ABSTRACT FROM AUTHOR]

Recently, a great many deep convolutional neural network (CNN)-based methods have been proposed for hyperspectral image (HSI) classification. Although the proposed CNN-based methods have the advantages of spatial feature extraction, they are difficult to handle the sequential data with and CNNs are not good at modeling the long-range dependencies. However, the spectra of HSI are a kind of sequential data, and HSI usually contains hundreds of bands. Therefore, it is difficult for CNNs to handle HSI processing well. On the other hand, the Transformer model, which is based on an attention mechanism, has proved its advantages in processing sequential data. To address the issue of capturing relationships of sequential spectra in HSI in a long distance, in this study, Transformer is investigated for HSI classification. Specifically, in this study, a new classification framework titled spatial-spectral Transformer (SST) is proposed for HSI classification. In the proposed SST, a well-designed CNN is used to extract the spatial features, and a modified Transformer (a Transformer with dense connection, i.e., DenseTransformer) is proposed to capture sequential spectra relationships, and multilayer perceptron is used to finish the final classification task. Furthermore, dynamic feature augmentation, which aims to alleviate the overfitting problem and therefore generalize the model well, is proposed and added to the SST (SST-FA). In addition, to address the issue of limited training samples in HSI classification, transfer learning is combined with SST, and another classification framework titled transferring-SST (T-SST) is proposed. At last, to mitigate the overfitting problem and improve the classification accuracy, label smoothing is introduced for the T-SST-based classification framework (T-SST-L). The proposed SST, SST-FA, T-SST, and T-SST-L are tested on three widely used hyperspectral datasets. The obtained results reveal that the proposed models provide competitive results compared to the state-of-the-art methods, which shows that the concept of Transformer opens a new window for HSI classification. [ABSTRACT FROM AUTHOR]

The aniline point (AP) is an important physical property of a petroleum fraction. The AP gives an indication of the aromatic hydrocarbon content in a hydrocarbon mixture and can also be an indicator of the ignition point of a diesel fraction. In this study, common estimation methods were introduced and evaluated, and their limitations were analyzed. Multiple linear regression was used in constructing a quantitative function to solve for the AP using the average boiling point and specific gravity. The iterative modification algorithm of the ternary interaction algorithm was used to obtain the predicted value of the petroleum fraction AP, and the proposed algorithm was tested using 127 actual petroleum fractions. The average estimation deviation of the proposed method was 3.55%; hence, compared to the commonly used estimation methods, the prediction accuracy was significantly improved. This method offers important practical value in the calculation of the petroleum fraction AP and other petroleum fraction properties, thereby providing reference significance. [ABSTRACT FROM AUTHOR]

Hyperspectral remote sensing obtains abundant spectral and spatial information of the observed object simultaneously. It is an opportunity to classify hyperspectral imagery (HSI) with a fine-grained manner. In this study, the fine-grained classification of HSI, which contains a large number of classes, is investigated. On one hand, traditional classification methods cannot handle fine-grained classification of HSI well; on the other hand, deep learning methods have shown their powerfulness in fine-grained classification. So, in this paper, deep learning is explored for HSI supervised and semi-supervised fine-grained classification. For supervised HSI fine-grained classification, densely connected convolutional neural network (DenseNet) is explored for accurate classification. Moreover, DenseNet is combined with pre-processing technique (i.e., principal component analysis or auto-encoder) or post-processing technique (i.e., conditional random field) to further improve classification performance. For semi-supervised HSI fine-grained classification, a generative adversarial network (GAN), which includes a discriminative CNN and a generative CNN, is carefully designed. The GAN fully uses the labeled and unlabeled samples to improve classification accuracy. The proposed methods were tested on the Indian Pines data set, which contains 33,3951 samples with 52 classes. The experimental results show that the deep learning-based methods provide great improvements compared with other traditional methods, which demonstrate that deep models have huge potential for HSI fine-grained classification. [ABSTRACT FROM AUTHOR]

Capsule networks can be considered to be the next era of deep learning and have recently shown their advantages in supervised classification. Instead of using scalar values to represent features, the capsule networks use vectors to represent features, which enriches the feature presentation capability. This paper introduces a deep capsule network for hyperspectral image (HSI) classification to improve the performance of the conventional convolutional neural networks (CNNs). Furthermore, a modification of the capsule network named Conv-Capsule is proposed. Instead of using full connections, local connections and shared transform matrices, which are the core ideas of CNNs, are used in the Conv-Capsule network architecture. In Conv-Capsule, the number of trainable parameters is reduced compared to the original capsule, which potentially mitigates the overfitting issue when the number of available training samples is limited. Specifically, we propose two schemes: (1) A 1D deep capsule network is designed for spectral classification, as a combination of principal component analysis, CNN, and the Conv-Capsule network, and (2) a 3D deep capsule network is designed for spectral-spatial classification, as a combination of extended multi-attribute profiles, CNN, and the Conv-Capsule network. The proposed classifiers are tested on three widely-used hyperspectral data sets. The obtained results reveal that the proposed models provide competitive results compared to the state-of-the-art methods, including kernel support vector machines, CNNs, and recurrent neural network. [ABSTRACT FROM AUTHOR]