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Functional mobility tests, such as the L test of functional mobility, are recommended to provide clinicians with information regarding the mobility progress of lower-limb amputees. Smartphone inertial sensors have been used to perform subtask segmentation on functional mobility tests, providing further clinically useful measures such as fall risk. However, L test subtask segmentation rule-based algorithms developed for able-bodied individuals have not produced sufficiently acceptable results when tested with lower-limb amputee data. In this paper, a random forest machine learning model was trained to segment subtasks of the L test for application to lower-limb amputees. The model was trained with 105 trials completed by able-bodied participants and 25 trials completed by lower-limb amputee participants and tested using a leave-one-out method with lower-limb amputees. This algorithm successfully classified subtasks within a one-foot strike for most lower-limb amputee participants. The algorithm produced acceptable results to enhance clinician understanding of a person's mobility status (>85% accuracy, >75% sensitivity, >95% specificity). [ABSTRACT FROM AUTHOR]

Patients with Parkinson's disease (PD) often show early deficits in cognitive control, with primary difficulties in flexibility and relatively intact stable representations. The aim of our study was to assess executive function using an ecologically valid approach that combines measures of stability and flexibility. Fourteen patients without cognitive deficits and sixteen comparable control subjects completed a standardized neuropsychological test battery and a newly developed cognitive control challenge task (C3T). We found that the accuracy of C3T performance decreased with age in healthy participants and remained impaired in PD patients regardless of age. In addition, PD patients showed significantly lower overall performance for cognitive control tasks than healthy controls, even when they scored in the normal range on standardized neuropsychological tests. PD Patients responded significantly faster than healthy control subjects regarding flexible cognitive control tasks due to their impulsivity. Correlations showed that the C3T task targets multiple cognitive systems, including working memory, inhibition, and task switching, providing a reliable measure of complex cognitive control. C3T could be a valuable tool for characterizing cognitive deficits associated with PD and appears to be a more sensitive measure than standardized neuropsychological tests. A different assessment approach could potentially detect early signs of the disease and identify opportunities for early intervention with neuroprotective therapies. [ABSTRACT FROM AUTHOR]

The 6-min walk test (6MWT) is commonly used to assess a person's physical mobility and aerobic capacity. However, richer knowledge can be extracted from movement assessments using artificial intelligence (AI) models, such as fall risk status. The 2-min walk test (2MWT) is an alternate assessment for people with reduced mobility who cannot complete the full 6MWT, including some people with lower limb amputations; therefore, this research investigated automated foot strike (FS) detection and fall risk classification using data from a 2MWT. A long short-term memory (LSTM) model was used for automated foot strike detection using retrospective data (n = 80) collected with the Ottawa Hospital Rehabilitation Centre (TOHRC) Walk Test app during a 6-min walk test (6MWT). To identify FS, an LSTM was trained on the entire six minutes of data, then re-trained on the first two minutes of data. The validation set for both models was ground truth FS labels from the first two minutes of data. FS identification with the 6-min model had 99.2% accuracy, 91.7% sensitivity, 99.4% specificity, and 82.7% precision. The 2-min model achieved 98.0% accuracy, 65.0% sensitivity, 99.1% specificity, and 68.6% precision. To classify fall risk, a random forest model was trained on step-based features calculated using manually labeled FS and automated FS identified from the first two minutes of data. Automated FS from the first two minutes of data correctly classified fall risk for 61 of 80 (76.3%) participants; however, <50% of participants who fell within the past six months were correctly classified. This research evaluated a novel method for automated foot strike identification in lower limb amputee populations that can be applied to both 6MWT and 2MWT data to calculate stride parameters. Features calculated using automated FS from two minutes of data could not sufficiently classify fall risk in lower limb amputees. [ABSTRACT FROM AUTHOR]

Foot strike detection is important when evaluating a person's gait characteristics. Accelerometer and gyroscope signals from smartphones have been used to train artificial intelligence (AI) models for automated foot strike detection in able-bodied and elderly populations. However, there is limited research on foot strike detection in lower limb amputees, who have a more variable and asymmetric gait. A novel method for automated foot strike detection in lower limb amputees was developed using raw accelerometer and gyroscope signals collected from a smartphone positioned at the posterior pelvis. Raw signals were used to train a decision tree model and long short-term memory (LSTM) model for automated foot strike detection. These models were developed using retrospective data (n = 72) collected with the TOHRC Walk Test app during a 6-min walk test (6MWT). An Android smartphone was placed on a posterior belt for each participant during the 6MWT to collect accelerometer and gyroscope signals at 50 Hz. The best model for foot strike identification was the LSTM with 100 hidden nodes in the LSTM layer, 50 hidden nodes in the dense layer, and a batch size of 64 (99.0% accuracy, 86.4% sensitivity, 99.4% specificity, and 83.7% precision). This research created a novel method for automated foot strike identification in lower extremity amputee populations that is equivalent to manual labelling and accessible for clinical use. Automated foot strike detection is required for stride analysis and to enable other AI applications, such as fall detection. [ABSTRACT FROM AUTHOR]