1. Female Rat Behavior Effects from Low Levels of Hexavalent Chromium (Cr[VI]) in Drinking Water Evaluated with a Toxic Aging Coin Approach.
- Author
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Vielee, Samuel T., Isibor, Jessica, Buchanan, William J., Roof, Spencer H., Patel, Maitri, Meaza, Idoia, Williams, Aggie, Toyoda, Jennifer H., Lu, Haiyan, Wise, Sandra S., Kouokam, J. Calvin, Young Wise, Jamie, Aboueissa, AbouEl-Makarim, Cai, Jun, Cai, Lu, and Wise Jr., John P.
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AGE differences ,DRINKING age ,HEXAVALENT chromium ,POLLUTANTS ,GRIP strength ,DRINKING water - Abstract
We are facing a critical aging crisis, with geriatric populations (65+) growing to unprecedented proportions and ~4 million people (a 6.5-fold increase) expected to become centenarians by 2050. This is compounded by environmental pollution, which affects individuals of all ages and contributes to age-related diseases. As we have a limited understanding of how environmental pollutants affect older populations distinctly from younger populations, these longer-lived geriatric populations present a key knowledge gap. To address this knowledge gap, we employ a "Toxic Aging Coin" approach: heads consider how age impacts chemical toxicity, and tails consider how chemicals act as gerontogens—or how they accelerate biological aging. We employed this approach to investigate hexavalent chromium (Cr[VI]) impacts on female rats exposed to 0.05 or 0.1 mg Cr(VI)/L in drinking water for 90 days; these are the maximum contaminant levels (i.e., the highest levels permitted) from the World Health Organization and U.S. Environmental Protection Agency, respectively. During exposure, rats performed a battery of behavior assays to assess grip strength, locomotor coordination, anxiety, spatial memory, sociability, and social novelty preference. We observed age differences in Cr(VI) neurotoxicity, with grip strength, locomotor function, and spatial memory in middle-aged females being particularly affected. We further compared these results in females to results in males, noting many sex differences, especially in middle-aged rats. These data emphasize the need to consider age and sex as variables in toxicology and to revisit drinking water regulations for Cr(VI). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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