1. Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.
- Author
-
Piccinin E, Arconzo M, Graziano G, Vacca M, Peres C, Bellafante E, Villani G, and Moschetta A
- Subjects
- Animals, Female, Liver Diseases metabolism, Mice, MicroRNAs genetics, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha genetics, Real-Time Polymerase Chain Reaction, Liver metabolism, MicroRNAs metabolism, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha metabolism
- Abstract
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
- Published
- 2019
- Full Text
- View/download PDF