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Aroma is among of the most important criteria that indicate the quality of food and beverage products. Aroma compounds can be found as free molecules or glycosides. Notably, a significant portion of aroma precursors accumulates in numerous food products as nonvolatile and flavorless glycoconjugates, termed glycosidic aroma precursors. When subjected to enzymatic hydrolysis, these seemingly inert, nonvolatile glycosides undergo transformation into fragrant volatiles or volatiles that can generate odor-active compounds during food processing. In this context, microbial β-glucosidases play a pivotal role in enhancing or compromising the development of flavors during food and beverage processing. β-glucosidases derived from bacteria and yeast can be utilized to modulate the concentration of particular aroma and taste compounds, such as bitterness, which can be decreased through hydrolysis by glycosidases. Furthermore, oral microbiota can influence flavor perception by releasing volatile compounds that can enhance or alter the perception of food products. In this review, considering the glycosidic flavor precursors present in diverse food and beverage products, we underscore the significance of glycosidases with various origins. Subsequently, we delve into emerging insights regarding the release of aroma within the human oral cavity due to the activity of oral microbial glycosidases. [ABSTRACT FROM AUTHOR]

The challenge in the field of inertial confinement fusion (ICF) research is related to the study of alternative schemes for fuel ignition on laser systems of medium and megajoule scales. At the moment, it is considered promising to use the method of shock ignition of fuel in a pre-compressed cryogenic target using a focused shock wave (shock- or self-ignition (SI) mode). To confirm the applicability of this scheme to ICF, it is necessary to develop technologies for mass-fabrication of the corresponding targets with a spherically symmetric cryogenic layer (hereinafter referred to as SI-targets). These targets have a low initial aspect ratio Acl (Acl = 3 and Acl = 5) because they are expected to be more hydrodynamically stable during implosion. The paper discusses the preparation of SI-targets for laser experiments using the free-standing target (FST) layering method developed at the Lebedev Physical Institute (LPI). It is shown that, based on FST, it is possible to build a prototype layering module for in-line production of free-standing SI-targets, and the layering time, τform, does not exceed 30 s both for deuterium and deuterium-tritium fuel. Very short values of τform make it possible to obtain layers with a stable isotropic fuel structure to meet the requirements of implosion physics. [ABSTRACT FROM AUTHOR]

The paper presents the results of mathematical and experimental modeling of in-line production of inertial fusion energy (IFE) targets of a reactor-scaled design. The technical approach is the free-standing target (FST) layering method in line-moving spherical shells. This includes each step of the fabrication and injection processes in the FST transmission line (FST-TL) considered as a potential solution of the problem of mass target manufacturing. Finely, we discuss the development strategy of the FST-TL creation seeking to develop commercial power production based on laser IFE. [ABSTRACT FROM AUTHOR]

The purpose of this study was the identification of genetic lineages and antimicrobial resistance (AMR) and virulence genes in Klebsiella pneumoniae isolates associated with severe infections in the neuro-ICU. Susceptibility to antimicrobials was determined using the Vitek-2 instrument. AMR and virulence genes, sequence types (STs), and capsular types were identified by PCR. Whole-genome sequencing was conducted on the Illumina MiSeq platform. It was shown that K. pneumoniae isolates of ST14K2, ST23K57, ST39K23, ST76K23, ST86K2, ST218K57, ST219KL125/114, ST268K20, and ST2674K47 caused severe systemic infections, including ST14K2, ST39K23, and ST268K20 that were associated with fatal incomes. Moreover, eight isolates of ST395K2 and ST307KL102/149/155 were associated with manifestations of vasculitis and microcirculation disorders. Another 12 K. pneumoniae isolates of ST395K2,KL39, ST307KL102/149/155, and ST147K14/64 were collected from patients without severe systemic infections. Major isolates (n = 38) were XDR and MDR. Beta-lactamase genes were identified: blaSHV (n = 41), blaCTX-M (n = 28), blaTEM (n = 21), blaOXA-48 (n = 21), blaNDM (n = 1), and blaKPC (n = 1). The prevalent virulence genes were wabG (n = 41), fimH (n = 41), allS (n = 41), and uge (n = 34), and rarer, detected only in the genomes of the isolates causing severe systemic infections—rmpA (n = 8), kfu (n = 6), iroN (n = 5), and iroD (n = 5) indicating high potential of the isolates for hypervirulence. [ABSTRACT FROM AUTHOR]