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Anaerobic exercise decreases systemic pH and increases metabolic acidosis in athletes, altering the acid-base homeostasis. In addition, nutritional recommendations advising athletes to intake higher amounts of proteins and simple carbohydrates (including from sport functional supplements) could be detrimental to restoring acid-base balance. Here, this specific nutrition could be classified as an acidic diet and defined as 'Westernized athletic nutrition'. The maintenance of a chronic physiological state of low-grade metabolic acidosis produces detrimental effects on systemic health, physical performance, and inflammation. Therefore, nutrition must be capable of compensating for systemic acidosis from anaerobic exercise. The healthy gut microbiota can contribute to improving health and physical performance in athletes and, specifically, decrease the systemic acidic load through the conversion of lactate from systemic circulation to short-chain fatty acids in the proximal colon. On the contrary, microbial dysbiosis results in negative consequences for host health and physical performance because it results in a greater accumulation of systemic lactate, hydrogen ions, carbon dioxide, bacterial endotoxins, bioamines, and immunogenic compounds that are transported through the epithelia into the blood circulation. In conclusion, the systemic metabolic acidosis resulting from anaerobic exercise can be aggravated through an acidic diet, promoting chronic, low-grade metabolic acidosis in athletes. The individuality of athletic training and nutrition must take into consideration the acid-base homeostasis to modulate microbiota and adaptive physiological responses. [ABSTRACT FROM AUTHOR]

Domestic horses routinely participate in vigorous and various athletic activities. This enables the horse to serve as a model for studying athletic physiology and immunology in other species, including humans. For instance, as a model of physical efforts, such as endurance rides (long-distance running/aerobic exercise) and races (anaerobic exercise), the horse can be useful in evaluating post-exercise response. Currently, there has been significant interest in finding biomarkers, which characterize the advancement of training and adaptation to physical exercise in the horse. The parallels in cellular responses to physical exercises, such as changes in receptor expression and blood cell activity, improve our understanding of the mechanisms involved in the body's response to intense physical activity. This study focuses on the changes in levels of the pro- and anti-inflammatory cytokines and cellular response in the context of post-exercise immune response. Both the direction of changes in cytokine levels and cellular responses of the body, such as proliferation and expression of surface markers on lymphocytes, monocytes and neutrophils, show cross-functional similarities. This review reveals that horses are robust research models for studying the immune response to physical exercise in human athletes. [ABSTRACT FROM AUTHOR]

Tensiomyography (TMG) has been described as an effective method for identifying differences in muscle response to athletic training stimuli. However, there is a lack of studies that evaluated changes in muscle contractile properties in response to anaerobic effort and related these changes to Wingate test parameters in more than one lower limb superficial muscle. The main contribution of this work is to evaluate changes in the contractile properties of muscles in response to anaerobic exercise. In a group of 20 physically active men, the body composition analysis was performed using a Tanita DC-360 device. The anaerobic effort was assessed by a Wingate test (30 s), and the contractile properties of muscles were measured using a TMG S2 device. The TMG parameters were measured in selected superficial muscles of the dominant lower limb. The study also calculated indices of the differences (d) and the size of the effect (r). An anaerobic effort in the form of the Wingate test resulted in greater stiffness (Dm) in the vastus lateralis muscle (p = 0.0365; r = 0.47) and a delayed response to stimulus (Td) in the vastus lateralis (p = 0.0239; r = 0.51) and vastus medialis (p = 0.0031; r = 0.66) muscles. The half relaxation time (Tr) (p = 0.0478; r = 0.44) and sustained contraction time (Ts) (p = 0.0276; r = 0.49) in the rectus femoris muscle were also increased. In contrast, a prolonged stimulus-response time (Td) with a decrease in sustained contraction time (Ts) was observed in the gastrocnemius lateralis (Td: p = 0.0054; r = 0.64 and Ts: p = 0.0012; r = 0.74) and gastrocnemius medialis (Td: p = 0.0229; r = 0.52 and Ts: p = 0.0054; r = 0.64) muscles. A significant decrease in contraction time (Tc) (p = 0.0051; r = 0.63) occurred only in the soleus muscle. In addition, significant correlations were shown between selected changes in contractile properties of muscle and parameters of the Wingate anaerobic test. Anaerobic exercise has a significant effect on changes in skeletal muscle contractility parameters. TMG is an effective method for identifying differences in muscle response to sports training stimuli. [ABSTRACT FROM AUTHOR]

(1) Playing basketball entails intense anaerobic activities, including short sprints, sudden stops, rapid direction changes, and jumps. Common training methods for enhancing players' anaerobic fitness comprise sprint training, jump exercises, and interval training. The aim of this research was to compare the impact of three sprint-training methods on anaerobic capacity. (2) The study included 25 male basketball players, aged 16–18 years, from the National Youth League in Israel. The participants were divided into three groups: sled-pushing, sled-dragging (intervention), and no sled (control) sprint training. Twice-weekly sessions were conducted over a five-week period, in addition to their regular basketball training. Pre- and post-intervention tests included vertical and horizontal jumps, 5 and 20 m sprints, and agility tests. (3) The study revealed significant improvements in the horizontal jump in the sled-pushing group (≈3%) and a near-significant improvement in the sled-dragging group (≈2.9%). Less improvement was seen in the control group (≈1.8%). No improvements were seen in the vertical jump performance in any groups, despite an increase in the sled-pushing group (≈5.5%) and in the sled-dragging group (≈3%) compared to that in the control group (≈1.2%). Finally, no improvements were seen in sprint speed and agility in any group. (4) Despite the modest improvements observed in most tests across the three groups, the consistent and significant enhancement seen in the sled-pushing and sled-dragging groups compared to that in the control group suggests potential benefits for sled assistance in anaerobic training in young basketball players. [ABSTRACT FROM AUTHOR]

Adenosine triphosphate (ATP) is an energy and signaling molecule. It is synthesized endogenously and can be taken as an oral supplement. This review aimed to identify the effects of oral ATP supplementation on anaerobic exercise in healthy resistance-trained adults. A systematic review and meta-analysis were performed based on the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) criteria. The inclusion criteria were articles published from 2000 to 2022, with anaerobic variables (maximal strength, maximum repetitions, and maximum anaerobic power) measurable in healthy adults with experience in resistance training, only randomized placebo-controlled clinical trials (RCTs), and with the acute (a single dose 30 min to 24 h before the tests) and/or chronic (>1 day) oral supplementation of ATP. A total of five RCTs with 121 adult men were included. The oral ATP supplementation achieved significantly greater gains in maximal strength compared with the placebo (PL) (MD = 8.13 kg, 95%CI [3.36–12.90], p < 0.001). Still, no differences were observed in the maximum number of repetitions or the maximum anaerobic power. Furthermore, 400 mg of ATP showed improvement in anaerobic exercise regardless of the duration of the supplementation protocol. In conclusion, supplementation with 400 mg of ATP doses can improve maximal muscle strength in resistance-trained men. [ABSTRACT FROM AUTHOR]

This study aimed (1) to assess the validity of a modified method (Mmod) based on heart rate (HR)—oxygen uptake (VO2) regression functions to calculate total energy costs (Wtotal) and aerobic (Waer) and anaerobic alactic energy contribution (Wpcr) and (2) to analyse the physiological and energetic demands of high-level pommel horse routines (PH routines). The Mmod was developed because VO2 measurements are limited during high-level PH routines. Answering Part 1, nine male artistic gymnasts performed a PH routine where energy costs were calculated from VO2 measurements and then compared with energy costs determined from the HR- VO2 regressions of Mmod's two additional tests. Using the concordance correlation coefficient (CCC) and Deming regression, Waer (CCC = 0.955), Wpcr (CCC = 0.999), and Wtotal (CCC = 0.990) show substantial to almost perfect validity without constant or proportional bias. Data from eight further gymnasts performing a high-level PH routine and a graded exercise test (GXT), as well as four data sets from Part 1, were used to determine physiological and energetic demands using Mmod. VO2 and HR during PH routines reached 86.1% and 90.4% of the maximal values during GXT. Wpcr was 47.0%, anaerobic lactic energy contribution (Wblc) was 29.7%, and Waer was 23.3% of Wtotal required during PH routines. Summarising the energetic demands of high-level PH routines, they are mainly anaerobic, where Wpcr provides the largest energy share. Waer provides a substantial part of Wtotal and should therefore also be specifically trained. [ABSTRACT FROM AUTHOR]

Current studies report thermographic changes following aerobic or resistance exercise but not short, vigorous anaerobic exercise. Therefore, we investigated body surface temperature changes using thermal imaging following a short session of anaerobic exercise. We studied three different regions of interest (ROIs): the legs, chest, and forehead. Thermal imaging for each participant was performed before and immediately after completing a Wingate anaerobic test and every minute during a 15 min recovery period. Immediately after the test, the maximum temperature was significantly higher in all ROIs (legs, p = 0.0323; chest, p = 0.0455; forehead, p = 0.0444) compared to pre-test values. During the recovery period, both legs showed a significant and continuous temperature increase (right leg, p = 0.0272; left leg, p = 0.0382), whereas a non-significant drop was noted in the chest and forehead temperatures. Additionally, participants with a lower anaerobic capacity exhibited a higher delta increase in surface leg temperature than participants with higher anaerobic capacities, with a minimal change in surface leg temperature. This is the first study to demonstrate body surface temperature changes following the Wingate anaerobic test. This temperature increase is attributed to the high anaerobic mechanical power outputs achieved by the leg muscles and the time taken for temperature reduction post-exercise. [ABSTRACT FROM AUTHOR]

The aim of this study was to assess the effects of three warm-up durations on post-exercise oxidative stress biomarkers, as well as recovery from the Wingate test in 14 amateur handball players. These players completed the Wingate test three times: after 5 min, after 10 min, and then after 15 min of warm-up, spread over 2 weeks with an interval of 1 week between each session. At the end of each session of the Wingate test, blood samples were taken: at rest (PR), after warming up (PWU) and immediately at the end of the test (P0), then after 10-min (P10) and after 20-min (P20) of recovery. The measured parameters are the total antioxidant status (TAS), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), malondialdehyde (MDA), protein-bound-carbonyls (PCs) and thiobarbituric acid reactive substances (TBARSs). The main findings revealed that anaerobic exercise induces oxidative stress, as evidenced by changes in antioxidant status and significant increases in concentrations of the majority of oxidative stress indicators (p < 0.05). At P20, plasma GPx, SOD, GR, TBARSs, and PC contents, are lower and significantly different after a 15-min warm-up than after a 10-min or 5-min warm-up. ANOVA showed a significant "warm-up × recovery" effect on plasma GPx, SOD, GR, TBARSs, and PC contents [F(8.104) = 3.61; p < 0.001; η2p = 0.22, F(8.104): from 1.88 to 19.97; η2p: from 0.19 to 0.61: 0.05 < p < 0.001], respectively. We concluded that a 15-min warm-up was more efficient than the other duration in reducing a free radical rise, emphasizing the importance of the warm-up length on plasma oxidative stress biomarkers. [ABSTRACT FROM AUTHOR]

Background: Athletes in combat sports, such as judo, often experience muscle cell damage due to physical and metabolic stress. This study investigates the impact of anaerobic interval exercises involving both upper and lower limbs at different temperatures on physiological indicators. Methods: Fifteen judokas, with an average age of 20.7 ± 2.0 years, participated in the study. They had an average body height of 178 ± 6.3 cm, body mass of 76.3 ± 12.6 kg, VO2max of 43.2 ± 7.8 mL·kg−1, and peak power of 12.1 W·kg−1. The main experiment involved performing five sequences of pulsating exercise on a cycle ergometer for both upper and lower limbs. This was conducted in a thermoclimatic chamber set at temperatures of 21 ± 0.5 °C and 31 ± 0.5 °C with a relative humidity of 50 ± 5%. The sequences alternated pulsations of varying durations and loads between the upper and lower limbs, with a 15 min break following each sequence. Within each sequence, participants underwent four anaerobic limb tests. Biochemical markers, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and heat shock protein 70 (HSP70), were measured using the enzyme-linked immunosorbent assay (ELISA) method before and after exercise, and again at 1, 24, and 48 h post-exercise. Muscle cell damage was evaluated based on lactate dehydrogenase (LDH) activity and myoglobin (Mb) concentration. Results: Both temperature conditions elicited physiological and biochemical responses. Positive correlations were observed between white blood cell count (WBC) and LDH concentration at 21 °C, as well as between WBC and IL-6 at 21 °C. At 31 °C, correlations were seen between WBC and myoglobin, and WBC and LDH. Conclusions: Muscle cell damage was evident under both conditions, as indicated by increased myoglobin levels. These findings offer insights into training strategies and underscore the physiological responses observed in combat sports athletes. [ABSTRACT FROM AUTHOR]

The aim of this project was to indicate the optimal parameters such as frequency, duration of a single vibrotherapy, and body position, which will be used as a form of recovery modality after physical exercise. Sixteen healthy male volunteers were involved in this study. The aerobic and anaerobic capacity of participants was assessed. Each of the subjects performed a set of intensive physical exercises and then underwent vibrotherapy treatment. In random order, each of the men tested the effectiveness of eight of the combinations of frequency, duration, and body position. The effect of the procedure accelerating recovery was assessed 24 h after physical exercise with the Wingate test. Changes in oxygen saturation and biochemical markers (interleukins: Il-1β, Il-6, and creatine kinase: CK), hemoglobin (Hb), and hematocrit (Hct) were assessed 1 h and 24 h after the physical effort. Lactate concentrations were measured 3, 15, 30, and 60 min after the end of the vibration. It was indicated that the optimal treatment should be based on lower ranges of frequency values (2–52 Hz). The procedure with raised feet is also more beneficial than the flat, supine position. To improve the overall work, and a number of biochemical markers (CK and Il-1β), a 45 min treatment will be more efficient, because significantly lower CK activity was indicated for the 45 min treatment. For this duration, higher values of Il-1β were indicated in the measurement carried out for samples collected 60 min after the treatment and lower in the measurement carried out 24 h after the treatment. [ABSTRACT FROM AUTHOR]

Physical fitness tests are a standard means of evaluating the competence of police officers. This qualitative review aims (i) to document, compare, and examine the reference values available in the current literature regarding fitness tests for Law Enforcement Officers (LEOs), and (ii) to define reference values for the most used fitness tests to assess and predict police officer performance. A total of 1879 records were collected for review from two major literature databases, PubMed and ScienceDirect. After applying our exclusion criteria, a total of 19 studies were considered. All studies demonstrated acceptable methodological quality in fitness assessment, and the most used components were muscle strength, muscular endurance, muscle power, aerobic and anaerobic capacity, flexibility, and agility. This review provides (i) a methodological definition for the physical fitness assessment that helps select the most used fitness tests, (ii) a standardised methodology for establishing reference data for fitness tests appropriate for LEOs; and (iii) aggregate reference values for selected fitness tests. This may improve selection and retention procedures, considering that this group performs its duties in an environment and under conditions that differ from those of other occupational groups. Complementarily, this qualitative review also provides a foundation for developing effective interventions to improve each aspect of fitness testing for police officers. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate whether and how anaerobic fatigue induced by sport-specific exercise affects the postural control of highly-trained adolescent road cyclists. Twenty-three male athletes, aged 15–18 years, were included in the study. Postural control was assessed using the pedobarographic platform (bipedal upright stance, sequentially, with eyes open (EO) and closed (EC) for 60 s each, with a 30 s interval), before and 3 min after a 30 s all-out effort performed on the ergometer. The results showed significant increases in the 95%-confidence ellipse area (p-value 0.000 and 0.001 for EO and EC, respectively), as well as centre-of-pressure (CoP) range displacement in the anteroposterior (p-value 0.000 for both EO and EC) and mediolateral (p-value 0.011 and 0.001 for EO and EC, respectively) planes. In addition, a significant decrease in CoP mean sway frequency was observed (p-value 0.000 and 0.001 for EO and EC, respectively), but no changes were noted in CoP mean velocity (p-value 0.316 and 0.670 for EO and EC, respectively). In our study, it has been indicated that anaerobic fatigue induced by sport-specific exercise deteriorates postural control in adolescent cyclists. Moreover, cycling training may affect the quality of postural corrective reactions occurring in response to anaerobic fatigue. [ABSTRACT FROM AUTHOR]

The number of patients with post-COVID-19 syndrome continues to increase considerably, having serious healthcare, social and economic repercussions. The objective of this study is to describe the effectiveness of telerehabilitation to alleviate the symptoms of post-COVID-19 syndrome. A systematic review was conducted using the information available on four databases (PubMed, Medline, Scielo and PEDRo) on these patients until November 2022. The MeSH search terms were: Post-COVID syndrome, Post-COVID-19, Long COVID, Telerehabilitation, Physiotherapy, Rehabilitation, Virtual, Home care. Six articles were included which provided information on 140 patients, detailing their symptomatology, assessment, treatment and monitoring. The variables measured were dyspnea, fatigue, physical performance and quality of life. All studies included aerobic and anaerobic exercises. Most notable among the techniques used were rib cage expansion exercises, respiratory control and thoracic cage stretching, patient education, Mindfulness and virtual reality games to address physical, mental and relaxation aspects. The use of telerehabilitation could be an effective tool for the treatment of persistent symptoms after suffering from COVID-19. It has been shown in these studies that patients improve both their physical performance and their quality of life. [ABSTRACT FROM AUTHOR]

Background: Thermoregulatory processes play an important role during athletic competition. When athletes compete in an elevated ambient temperature, metabolic processes in their bodies become intensified. The main objective of the study was to determine changes in anaerobic total work (TW) and relative peak power (RPP) during a special judo fitness test at different ambient temperatures performed among judo athletes. Methods: The study included 15 judo athletes aged 20.7 ± 2.0 years, with a body height of 178 ± 6.3 cm, body mass totalling 76.3 ± 12.6 kg, VO2max at 43.2 ± 7.8 mL·kg−1, and peak power of 12.1 W·kg−1. A complete set of results was obtained for 10 athletes. In the main part of the examinations, judo athletes performed five sequences (7.20 min each), alternating efforts on a leg cycle and arm cycle ergometer in a thermal chamber at 21 ± 0.5 °C and 31 ± 0.5 °C. The efforts differed from typical interval exercise by alternating upper- and lower-limb efforts, as well as with regard to the duration of those efforts. Each sequence was followed by a 15 min interval for rest. In each sequence, subjects performed four anaerobic tests with the upper and lower limbs. Results: In the first of five series of efforts performed with the lower limbs (LL) at an ambient temperature of 21 °C, statistically significant differences (p < 0.001) were found between the mean RPP values recorded during the first and third and fourth repetitions, and between the second versus third and fourth repetitions. Statistically significant differences were also observed between the first and fourth efforts performed by the LL at 31 °C (p < 0.001) and between the second and third performed using the upper limbs (UL) at an ambient temperature of 21 °C Conclusions: Varying ambient thermal conditions do not affect the size of generated relative peak power or the volume of work performed in pulsating anaerobic exercise. [ABSTRACT FROM AUTHOR]

Simple Summary: Sport horses competing in exhausting sporting events require special attention to ensure their welfare. Changes in acute phase response induced by both aerobic and anaerobic exercise are studied for understanding the physiological response to strenuous exercise. We suggest that endurance racing induces acute phase response in horses, characterized by a decrease in calprotectin and haptoglobin values, and an increase in concentrations of ceruloplasmin and albumin, with more pronounced changes noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races. This study aimed to evaluate if exercise-induced acute phase response (APR) occurs in endurance horses in response to the race. The study included 23 horses competing in an endurance competition with a successfully passed clinical examination before the race. Blood samples were collected before the start and within 30 min after the end of the race. Haematological and biochemical tests were performed and correlated to acute phase biomarkers changes. Values of calprotectin and haptoglobin (Hp) decreased after the races compared to values before, while concentrations of ceruloplasmin and albumin recorded a significant increase. Greater changes in calprotectin values were noted in Arabian horses compared to other breeds. Values of Hp showed a significantly greater decrease after longer races. Based on study results, endurance racing induces APR in horses characterised by significant changes in selected acute phase biomarkers. More pronounced changes were noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races. [ABSTRACT FROM AUTHOR]

Simple Summary: The bulk of research on caffeine as an ergogenic aid has been on endurance performance, however there is evidence that caffeine can enhance short-term high-intensity performance. Caffeine may have an ergogenic impact during anaerobic exercise by facilitating central effects by antagonizing adenosine receptors, hence decreasing the detrimental effects of adenosine on neurotransmission, arousal, and pain perception. Caffeine intake also activates the central nervous system, which promotes alertness and concentration. Additionally, athletes typically consume coffee containing caffeine. To date, the bulk of study has focused on the administration of 3–9 mg/kg of anhydrous caffeine, as opposed to the readily accessible source of caffeine, coffee, and has mostly been conducted on males. Consequently, there is a dearth of study evaluating the ergogenic impact of caffeine on females, particularly when consuming alternative caffeine delivery methods, such as coffee. The current study is the first to investigate the effects of low (3 mg/kg) and moderate (6 mg/kg) doses of caffeine from coffee on repeated sprint performance in females. The aim of this study was to determine the effect of low and moderate doses of caffeine ingestion via caffeinated coffee on repeated sprint test (RST) and plasma catecholamine concentration in trained female team-sport athletes. In a randomized, double-blind, crossover design, 13 female team-sport athletes (VO2max: 48.7 ± 4 mL·kg·min−1) completed three RST trials, separated by 4-day, 60 min post-ingestion of either 3 mg·kg−1 (LCOF) or 6 mg·kg−1 (MCOF) or placebo (PLA). The RST consisted of 12 × 4 s sprints on a cycle ergometer interspersed with 20 s of active recovery. Blood lactate (BLa) and glucose (GLU) and epinephrine and norepinephrine concentrations were collected before and 60 min after coffee ingestion, and after RST. Heart rate (HR) and ratings of perceived exertion (RPE) were measured at the beginning of RST, and after the 6th and 12th sprints. Average peak power score during RST was significantly improved after LCOF (p = 0.016) and MCOF (p = 0.041) compared to PLA, but peak and mean power output of the individual sprints, and fatigue index were not different between trials (all p > 0.05). Epinephrine and norepinephrine concentrations were significantly higher before and after RST in LCOF and MCOF compared to PLA (all p < 0.05). BLa was also higher after RST in both LCOF and MCOF compared to PLA (p = 0.005). HR, RPE, and GLU were not different between conditions (p > 0.05). In conclusion, low and moderate dose of caffeine ingestion can enhance the average peak power score during repeated sprints. These findings partly support low and moderate doses of caffeine supplementation via coffee as a nutritional ergogenic aid for trained female team-sport players during repeated sprint exercise. [ABSTRACT FROM AUTHOR]

Lactate dehydrogenase (LDH) catalyzes the reversible conversion of L-lactate to pyruvate. LDH-A deficiency is an autosomal recessive disorder (glycogenosis type XI, OMIM#612933) caused by mutations in the LDHA gene. We present two young adult female patients presenting with intolerance to anaerobic exercise, episodes of rhabdomyolysis, and, in one of the patients, psoriasis-like dermatitis. We identified in the LDHA gene a homozygous c.410C>A substitution that predicts a p.Ser137Ter nonsense mutation in Patient One and a compound heterozygous c.410C>A (p.Ser137Ter) and c.750G>A (p.Trp250Ter) nonsense mutation in Patient Two. The pathogenicity of the variants was demonstrated by electrophoretic separation of LDH isoenzymes. Moreover, a flat lactate curve on the forearm exercise test, along with the clinical combination of myopathy and psoriatic-like dermatitis, can also lead to the diagnosis. [ABSTRACT FROM AUTHOR]

We compared the effect of bilateral knee joint cooling with or without a pre-cooling warm-up on sprint cycling performance to a non-cooling control condition. Seventeen healthy young males (25 ± 2 years, 174 ± 6 cm, 70 ± 9 kg) performed three conditions in a counterbalanced order (condition 1: warming + cooling + cycling; condition 2: cooling + cycling; condition 3: cycling). For warming, a single set of cycling intervals (a 10 s sprint with maximal effort followed by a 180 s active recovery; resistive load 4% and 1% body mass for sprint and recovery, respectively) was performed. For cycling, five sets of cycling intervals were performed. For cooling, 20 min of bilateral focal knee joint cooling was applied. Peak and average values of anaerobic capacity and wheel cadence during each set across conditions were statistically compared. There was no condition effect over set (condition × set) in anaerobic capacity (F8,224 < 1.49, p > 0.16) and wheel cadence (F8,224 < 1.48, p > 0.17). Regardless of set (condition effect: F2,224 > 8.64, p < 0.0002), conditions 1 and 2 produced higher values of anaerobic capacity (p ≤ 0.05). Similarly (condition effect: F2,224 > 4.62, p < 0.02), condition 1 showed higher wheel cadence (p < 0.02) than condition 3. A bilateral joint cooling for 20 min with or without pre-cooling warm-up may improve overall sprint cycling capacity during five sets of cycling intervals when compared to the non-cooling condition. [ABSTRACT FROM AUTHOR]

The cardiovascular benefit of statins is well established. However, only 20% of high-risk patients remain adequately adherent after 5 years of treatment. Among reasons for discontinuation, statin associated-muscle pain symptoms are the most prevalent. Aim of the present study was to evaluate the impact of high dose atorvastatin on skeletal muscle mitochondrial activity, aerobic and anaerobic exercise, and axonal excitability in a murine model of atherosclerosis. ApoE-/- mice were fed 12 weeks a high-fat high-cholesterol diet alone or containing atorvastatin (40 mg/Kg/day). Outcomes were the evaluation of muscle mitochondrial functionality, locomotion, grip test, and axonal excitability (compound action potential recording analysis of Aα motor propioceptive, Aβ mechanoceptive and C nociceptive fibres). Atorvastatin led to a reduction in muscle mitochondrial biogenesis and mitochondrial ATP production. It did not affect muscular strength but led to a time-dependent motor impairment. Atorvastatin altered the responsiveness of mechanoceptive and nociceptive fibres, respectively, the Aβ and C fibres. These findings point out to a mild sensitization on mechanical, tactile and pain sensitivity. In conclusion, although the prevalence of muscular side effects from statins may be overestimated, understanding of the underlying mechanisms can help improve the therapeutic approach and reassure adherence in patients needing-to-be-treated. [ABSTRACT FROM AUTHOR]

Simple Summary: Change-of-direction maneuvers are frequently performed by police officers and athletes. These maneuvers are typically performed with the intention of being maximally fast. Often, an officer or an athlete will run at a certain pace before commencing a change-of-direction speed maneuver. Depending on the duration and intensity of this running activity, their performance of the change-of-direction speed maneuver may be reduced. This study determined the degree to which the preceding maximal and submaximal anaerobic and aerobic activity affect the subsequent performance of the change-of-direction speed maneuver. We found that both anaerobic and aerobic running activities decreased the speed of the subsequent performance on the Illinois Agility Test. We also found that anaerobic running at 85% and 90% had a greater impact on change-of-direction speed performance than did aerobic running at these intensities. Above 90% intensity, anaerobic and aerobic performance similarly impacted the change-of-direction speed. As such, given the requirement for tactical personnel and intermittent, multidirectional sports athletes to perform a change-of-direction speed maneuver following a period of submaximal anaerobic or aerobic activity, increasing fitness may be a means of reducing the negative impacts of preceding submaximal impacts on change-of-direction speed performance. Change-of-direction speed (CODS) directly impacts success in sports, police, and military performance. Movements requiring CODS are often preceded by aerobic or anaerobic running. Therefore, this study investigated the effects of maximal and submaximal anaerobic and aerobic running on subsequent CODS performance. A sample of 50 police students (42% female and 58% male) performed a maximal 300-yard shuttle run test (SR300y) and a 2.4-km Cooper test (CT2.4km) at maximal effort and also at 95, 90, 85, 80, and 75% of maximal effort. CODS was assessed using the Illinois Agility Test (IAT) immediately following each intensity level of each test at 12 separate testing sessions. To avoid fatigue, the period between each consecutive session was a minimum of 3 days. Paired samples t-tests were used to determine the differences between the two conditions (anaerobic lactic and aerobic) and for the IAT. A repeated measure analysis of variance with a Bonferroni post hoc test was used to analyze partial effects of different running intensities on the IAT. A significant reduction in speed was observed between the initial IATmax time and the IATmax time after performing the SR300y at intensities of 95, 90, 85, and 80% of maximal speed on this test. IAT performance was significantly slower when performed after the CT2.4km at 95 and 90% of maximal aerobic speed. The effects of the SR300y on the IAT were significantly greater than the effects of the CT2.4km. No significant differences were found by sex. Building up to 90% intensity, anaerobic running has a greater negative impact on subsequent CODS performance than does aerobic running. [ABSTRACT FROM AUTHOR]

Cardiorespiratory or aerobic exercise immediately after practice of an upper-extremity motor skill task can facilitate skill consolidation, as demonstrated by enhanced performances at 24 h and 7-day retention tests. The purpose of this study was to examine the effect of acute cardiorespiratory exercise on motor skill consolidation when skill practice involved low and high levels of contextual interference introduced through repetitive and interleaved practice schedules, respectively. Forty-eight young healthy adults were allocated to one of four groups who performed either repetitive or interleaved practice of a pinch grip motor sequence task, followed by either a period of seated rest or a bout of high-intensity interval cycling. At pre- and post-practice and 24 h and 7-day retention tests, we assessed motor skill performance and β-band (15–35 Hz) intermuscular coherence using surface electromyography (EMG) collected from the abductor pollicis brevis and first dorsal interosseous. At the 7-day retention test, off-line consolidation was enhanced in the cardiorespiratory exercise relative to the rest group, but only among individuals who performed interleaved motor skill practice (p = 0.02). Similarly, at the 7-day retention test, β-band intermuscular coherence increased to a greater extent in the exercise group than in the rest group for those who performed interleaved practice (p = 0.02). Under the present experimental conditions, cardiorespiratory exercise preferentially supported motor skill consolidation and change in intermuscular coherence when motor skill practice involved higher rather than lower levels of contextual interference. [ABSTRACT FROM AUTHOR]

Oxidative stress has been recognized as a contributing factor in aging and in the progression of multiple neurological disorders such as Parkinson's disease, Alzheimer's dementia, ischemic stroke, and head and spinal cord injury. The increased production of reactive oxygen species (ROS) has been associated with mitochondrial dysfunction, altered metal homeostasis, and compromised brain antioxidant defence. All these changes have been reported to directly affect synaptic activity and neurotransmission in neurons, leading to cognitive dysfunction. In this context two non-invasive strategies could be employed in an attempt to improve the aforementioned stressful brain status. In this regard, it has been shown that exercise could increase the resistance against oxidative stress, thus providing enhanced neuroprotection. Indeed, there is evidence suggesting that regular physical exercise diminishes BBB permeability as it reinforces antioxidative capacity, reduces oxidative stress, and has anti-inflammatory effects. However, the differential effects of different types of exercise (aerobic exhausted exercise, anaerobic exercise, or the combination of both types) and the duration of physical activity will be also addressed in this review as likely determinants of therapeutic efficacy. The second proposed strategy is related to the use of probiotics, which can also reduce some biomarkers of oxidative stress and inflammatory cytokines, although their underlying mechanisms of action remain unclear. Moreover, various probiotics produce neuroactive molecules that directly or indirectly impact signalling in the brain. In this review, we will discuss how physical activity can be incorporated as a component of therapeutic strategies in oxidative stress-based neurological disorders along with the augmentation of probiotics intake. [ABSTRACT FROM AUTHOR]

The purpose of this study was to investigate the effects of listening to preferred versus non-preferred warm-up music on anaerobic sprint performance in Division I NCAA female athletes. Female collegiate athletes (n = 14) were recruited for this study. In a counterbalanced, crossover study design, participants completed two separate visits, each with a different warm-up music condition: preferred (Pref) or non-preferred (Non-pref). During each visit, participants completed a 3 min standardized cycling warm-up at 50 Watts while listening to Pref or Non-pref music. Following this, participants completed 3 - 15 s Wingate Anaerobic Tests (WAnTs) with a 2 min active recovery period in between tests. Motivation to exercise was measured immediately following the warm-up (WU), WAnT1, WAnT2, and WAnT3. The rate of perceived exertion (RPE) was also measured after each WAnT. Each visit was separated by a minimal recovery period of 48 h. Mean power, total work, RPE, and motivation were analyzed. Mean power (p = 0.044; d = 0.91) and total work (p = 0.045; d = 0.78) were significantly higher during the Pref music condition versus Non-pref. RPE remained unchanged regardless of condition (p = 0.536; d = 0.01). Motivation was significantly higher with Pref warm-up music compared to Non-pref (p < 0.001; d = 1.55). These results show that listening to Pref warm-up music has an ergogenic benefit during repeated sprints in comparison to Non-pref music and improves motivation to exercise. Listening to warm-up music prior to high-intensity repeated exercise may aid in optimizing performance and training in collegiate athletes. [ABSTRACT FROM AUTHOR]

To examine the efficacy of wild ginseng extract (WGE) on psychomotor and neuromuscular performance recovery following acute eccentric exercise. This study was a double-blind, crossover, and placebo-controlled design with a 14-day washout period. Ten male adults, aged 27.1 ± 4.33 years old, voluntarily participated in the study. Subjects were assigned to one of two parallel conditions (WGE or placebo) in a counterbalanced manner. Subjects consumed two packs of WGE (350 mg/package) or placebo drink immediately after acute eccentric exercise and the following four days. The eccentric exercise consisted of 20 min of downhill running at 60% of VO2peak and five sets (of 20) of drop jump exercise. Computer-based cognitive function test and neuromuscular performance tests, including straight leg raise, vertical jump, isometric leg strength, and anaerobic power test were administered four times, at baseline, 2 h, 48 h, and 96 h after acute exercise. The interleukin-6 (IL-6), myoglobin, cortisol, total antioxidant capacity (TAC), and perceived muscle soreness were also assessed at each time point. A significance level was set at 0.05. No significant differences between the WGE and the placebo groups were observed in psychomotor and neuromuscular performance variables. Blood markers, including IL-6 (p = 0.013), myoglobin (p < 0.001), and cortisol level (p = 0.047) were changed significantly across the time. A post-hoc test revealed that a significant increase in IL-6 was observed only in the placebo group (p = 0.014), while no significant changes found in the WGE condition. The perceived muscle soreness was not different between the WGE and the placebo conditions. The administration of WGE immediately after acute eccentric exercise and the following four days have no benefits on psychomotor and neuromuscular performance recovery in healthy adults. However, the acute WGE supplementation may attenuate the eccentric exercise-induced inflammatory process, such as IL-6, but future study with a large sample size is required to clarify the anti-inflammation process in response to acute eccentric exercise. [ABSTRACT FROM AUTHOR]

There is ample evidence that regular moderate to vigorous aerobic physical activity is related to a reduced risk for various forms of cancer to suggest a causal relationship. Exercise is associated with positive changes in fitness, body composition, and physical functioning as well as in patient-reported outcomes such as fatigue, sleep quality, or health-related quality of life. Emerging evidence indicates that exercise may also be directly linked to the control of tumour biology through direct effects on tumour-intrinsic factors. Beside a multitude of effects of exercise on the human body, one underscored effect of exercise training is to target the specific metabolism of tumour cells, namely the Warburg-type highly glycolytic metabolism. Tumour metabolism as well as the tumour-host interaction may be selectively influenced by single bouts as well as regularly applied exercise, dependent on exercise intensity, duration, frequency and mode. High-intensity anaerobic exercise was shown to inhibit glycolysis and some studies in animals showed that effects on tumour growth might be stronger compared with moderate-intensity aerobic exercise. High-intensity exercise was shown to be safe in patients; however, it has to be applied carefully with an individualized prescription of exercise. [ABSTRACT FROM AUTHOR]

It was observed previously that New Zealand blackcurrant (NZBC) extract reduced slowing of the maximal 15 m sprint speed during the Loughborough Intermittent Shuttle Test. We examined the effect of NZBC extract on the performance of the Running Based Anaerobic Sprint Test (RAST, 6 × 35-m sprints with 10 seconds passive recovery) in trained youth and recreationally active football players. Fifteen recreationally active (University team) (age: 20 ± 1 years, height: 174 ± 19 cm, body mass: 80 ± 13 kg) and nine trained youth players (English professional club) (age: 17 ± 0 years, height: 178 ± 8 cm, body mass: 69 ± 9 kg, mean ± SD) participated in three testing sessions. Prior to the RASTs, participants consumed two capsules of NZBC extract (600 mg·day-1 CurraNZ®) or placebo (P) for 7 days (double blind, randomised, cross-over design, wash-out at least 14 days). Ability difference between groups was shown by sprint 1 time. In the placebo condition, trained youth players had faster times for sprint 1 (5.00 ± 0.05 s) than recreationally active players (5.42 ± 0.08 s) (p < 0.01). In trained youth players, there was a trend for an effect of NZBC extract (p = 0.10) on the slowing of the sprint 1 time. NZBC extract reduced slowing of the sprint 5 time (P: 0.56 ± 0.22 s; NZBC: 0.35 ± 0.25, p = 0.02) and this was not observed in recreationally active players (P: 0.57 ± 0.48 s; NZBC: 0.56 ± 0.33, p = 0.90). For fatigue index, expressed as a % change in fastest sprint time, there was a strong trend to be lower in both trained youth and recreationally active players combined by NZBC extract (P: -13 ± 7%; NZBC: -11 ± 6%, p = 0.06) with 12 participants (five trained youth) experiencing less fatigue. New Zealand blackcurrant extract seems to benefit repeated sprint performance only in trained football players. [ABSTRACT FROM AUTHOR]

Acute ergogenic effects of wearing occlusal splints have been reported for aerobic and anaerobic exercises, but the literature centered on performance improvement by using jaw repositioning splints is scarce. We aimed to analyze the effect of wearing a 50% lower jaw advancement splint on biophysical and perceptual responses at low to severe running intensities. Sixteen middle- and long-distance runners performed twice a 7 × 800 m intermittent running protocol (with 1 km·h−1 increments and 30 s rest periods) in an outdoor track field using two lower intraoral splints (a placebo and a lower jaw advancer). These devices were custom manufactured for each participant and a randomized and repeated measure design was used to compare conditions. No differences between placebo and lower jaw advancer were found (e.g., 52.1 ± 9.9 vs. 53.9 ± 10.7 mL·kg−1·min−1 of oxygen uptake, 3.30 ± 0.44 vs. 3.29 ± 0.43 m of stride length and 16 ± 3 vs. 16 ± 2 Borg scores), but small effects were sometimes observed (e.g., 109.2 ± 22.5 vs. 112.7 ± 25.2 L·min−1 of ventilation, ES = −0.42). Therefore, this jaw advancement splint had no substantial ergogenic effect on biophysical and perceptual responses when running at different intensities. [ABSTRACT FROM AUTHOR]

Hypertensive disorders of pregnancy (HDP) are the most common medical complication in pregnancy, affecting approximately 10–15% of pregnancies worldwide. HDP are a major cause of maternal and perinatal morbidity and mortality, and each year, worldwide, around 70,000 mothers and 500,000 babies die because of HDP. Up-to-date high-quality systematic reviews quantifying the role of exercise and the risks of developing HDP are currently lacking. Physical exercise is considered to be safe and beneficial to pregnant women. Supervised exercise has been shown to be safe and to be more beneficial than unsupervised exercise in the general population, as well as during pregnancy in women with obesity and diabetes. Therefore, we undertook a systematic review and meta-analysis to investigate the effects of women performing supervised exercise during pregnancy compared to a control group (standard antenatal care or unsupervised exercise) on the development of HDP. We searched Medline, Embase, CINHAL, and the Cochrane Library, which were searched from inception to December 2021. We included only randomized controlled trials (RCTs) investigating the development of HDP compared to a control group (standard antenatal care or unsupervised exercise) in pregnant women performing supervised exercise. Two independent reviewers selected eligible trials for meta-analysis. Data collection and analyses were performed by two independent reviewers. The PROSPERO registration number is CRD42020176814. Of 6332 articles retrieved, 16 RCTs met the eligibility criteria, comparing a total of 5939 pregnant women (2904 pregnant women in the intervention group and 3035 controls). The risk for pregnant women to develop HDP was significantly reduced in the intervention compared to the control groups, with an estimated pooled cumulative incidence of developing HDP of 3% in the intervention groups (95% CI: 3 to 4) and of 5% in the control groups (95% CI: 5 to 6), and a pooled odds ratio (OR) comparing intervention to control of 0.54 (95% CI:0.40 to 0.72, p < 0.001). A combination of aerobic and anaerobic exercise, or yoga alone, had a greater beneficial effect compared to performing aerobic exercise only (mixed-OR = 0.50, 95% CI:0.33 to 0.75, p = 0.001; yoga-OR = 0.28, 95% CI:0.13 to 0.58, p = 0.001); aerobic exercise only-OR = 0.87, 95% CI:0.55 to 1.37, p = 0.539). Pregnancy is an opportunity for healthcare providers to promote positive health activities, thus optimizing the health of pregnant women with potential short- and long-term benefits for both mother and child. This systematic review and meta-analysis support a beneficial effect of either structured exercise (combination of aerobic, strength, and flexibility workouts) or yoga for preventing the onset of HDP. Yoga, considered a low-impact physical activity, could be more acceptable and safer for women in pregnancy in reducing the risk of developing HDP. [ABSTRACT FROM AUTHOR]

Physical activity may benefit health by modulating oxidative stress and inflammation. However, the selection of suitable exercise-induced oxidative stress biomarkers is still challenging. This study aimed at systematically summarizing the available evidence on exercise-induced oxidative stress measured in urine and/or saliva. Two meta-analyses including the most frequently quantified biomarkers of oxidative stress, namely, urinary isoprostane and DNA oxidation products, were performed. Three electronic databases (PubMed, EMBASE and Cochrane CENTRAL) were interrogated. Among 4479 records, 43 original articles were included in the systematic review and 11 articles were included in meta-analysis I and II, respectively. We observed a pooled trend of increase of urinary isoprostanes in response to physical activity (+0.95, 95% CI: −0.18; 2.09). In comparison with aerobic exercise, anaerobic training determined a greater induction of isoprostanes (+5.21, 95% CI: 2.76; 7.66, p < 0.0001), which were markedly increased after vigorous physical activity (+6.01, 95% CI: 1.18; 10.84, p < 0.001) and slightly decreased in response to exercise interventions protracted over time (e.g., months) (−1.19, 95% CI: −2.25; −0.12, p < 0.001). We recommend the most integrative approach of oxidative stress multi-marker panels in response to physical activity instead of selecting one preferential biomarker to quantify physical activity-induced oxidative stress in humans. [ABSTRACT FROM AUTHOR]

Changes of circulating free plasma DNA (cfDNA) are associated with different types of tissue injury, including those induced by intensive aerobic and anaerobic exercises. Observed changes are dependent from induced inflammation, and thus it may be a potential marker for athletic overtraining. We aimed to identify the response of cfDNA to different types of exercise, with association to exercise intensity as a potential marker of exercise load. Fifty volunteers (25 athletes and 25 physically active men) were assigned to the study and performed maximal aerobic (Bruce test) and anaerobic (Wingate Anaerobic Test) test. Blood samples for cfDNA analysis were collected at four time-points: before, 2–5 min after, 30 min after and 60 min after each type of maximal physical activity. The two-way ANOVA revealed a significant effect of group factor on serum cfDNA concentrations (32.15% higher concentration of cfDNA in the athletes). In turn the results of the post hoc test for the interaction of the repeated measures factor and the group showed that while the concentration of cfDNA decreased by 40.10% in the period from 30 min to 60 min after exercise in the control group, the concentration of cfDNA in the group of athletes remained at a similar level. Our analysis presents different responses depending on the intensity and duration of exercise. Our observations imply that formation of cfDNA is associated with response to physical activity but only during maximal effort. [ABSTRACT FROM AUTHOR]

Pre-competitive conditioning has become a substantial part of successful performance. In addition to temperature changes, a metabolic conditioning can have a significant effect on the outcome, although the right dosage of such a method remains unclear. The main goal of the investigation was to measure how a lower body high-intensity anaerobic cycling pre-load exercise (HIE) of 25 s affects cardiorespiratory and metabolic responses in subsequent upper body performance. Thirteen well-trained college-level male cross-country skiers (18.1 ± 2.9 years; 70.8 ± 7.6 kg; 180.6 ± 4.7 cm; 15.5 ± 3.5% body fat) participated in the study. The athletes performed a 1000-m maximal double-poling upper body ergometer time trial performance test (TT) twice. One TT was preceded by a conventional low intensity warm-up (TTlow) while additional HIE cycling was performed 9 min before the other TT (TThigh). Maximal double-poling performance after the TTlow (225.1 ± 17.6 s) was similar (p > 0.05) to the TThigh (226.1 ± 15.7 s). Net blood lactate (La) increase (delta from end of TT minus start) from the start to the end of the TTlow was 10.5 ± 2.2 mmol L−1 and 6.5 ± 3.4 mmol L−1 in TThigh (p < 0.05). La net changes during recovery were similar for both protocols, remaining 13.5% higher in TThigh group even 6 min after the maximal test. VCO2 was lower (p < 0.05) during the last 400-m split in TThigh, however during the other splits no differences were found (p < 0.05). Respiratory exchange ratio (RER) was significantly lower in TThigh in the third, fourth and the fifth 200 m split. Participants individual pacing strategies showed high relation (p < 0.05) between slower start and faster performance. In conclusion, anaerobic metabolic pre-conditioning leg exercise significantly reduced net-La increase, but all-out upper body performance was similar in both conditions. The pre-conditioning method may have some potential but needs to be combined with a pacing strategy different from the usual warm-up procedure. [ABSTRACT FROM AUTHOR]

Background: The objectives of this systematic review and meta-analysis were to quantify the effectiveness of endurance training (ET) on aerobic performance (i.e., peak oxygen uptake (VO2peak)) in healthy and unhealthy middle and very old adults aged 70 years and older, and to provide dose–response relationships of training prescription variables (in terms of frequency, and volume). Methods: Several scholarly databases (i.e., PubMed/MEDLINE, SpringerLink, ScienceDirect Journals, and Taylor & Francis Online—Journals) were searched, identifying randomized controlled studies that investigated the effectiveness of ET on VO2peak in older adults. Standardized mean differences (SMD) were calculated. Results: In terms of changes differences between experimental and control group, ET produced significant large effects on VO2peak performance (SMD = 2.64 (95%CI 0.97–4.31)). The moderator analysis revealed that "health status" variable moderated ET effect onVO2peak performance. More specifically, ET produced larger SMD magnitudes on VO2peak performance in healthy compared with unhealthy individuals. With regard to the dose–response relationships, findings from the meta-regression showed that none of the included training prescription variables predicted ET effects on VO2peak performance. Conclusions: ET is an effective mean for improving aerobic performance in healthy older adults when compared with their unhealthy counterparts. [ABSTRACT FROM AUTHOR]

Lactate is widely measured in critically ill patients as a robust indicator of patient deterioration and response to treatment. Plasma concentrations represent a balance between lactate production and clearance. Analysis has typically been performed with the aim of detecting tissue hypoxia. However, there is a diverse range of processes unrelated to increased anaerobic metabolism that result in the accumulation of lactate, complicating clinical interpretation. Further, lactate levels can change rapidly over short spaces of time, and even subtle changes can reflect a profound change in the patient's condition. Hence, there is a significant need for frequent lactate monitoring in critical care. Lactate monitoring is commonplace in sports performance monitoring, given the elevation of lactate during anaerobic exercise. The desire to continuously monitor lactate in athletes has led to the development of various technological approaches for non-invasive, continuous lactate measurements. This review aims firstly to reflect on the potential benefits of non-invasive continuous monitoring technology within the critical care setting. Secondly, we review the current devices used to measure lactate non-invasively outside of this setting and consider the challenges that must be overcome to allow for the translation of this technology into intensive care medicine. This review will be of interest to those developing continuous monitoring sensors, opening up a new field of research. [ABSTRACT FROM AUTHOR]

Background: Chronotropic incompetence in patients taking beta-blockers is associated with poor prognosis; however, its impact on exercise capacity (EC) remains unclear. Methods: We analyzed data from consecutive patients taking beta-blockers referred for cardiopulmonary exercise testing to assess EC. Chronotropic incompetence was defined as chronotropic index (CI) ≤ 62%. Results: Among 140 patients all taking beta-blockers (age 61 ± 9.7 years; 73% males), 64% with heart failure, chronotropic incompetence was present in 80.7%. EC assessed as peak oxygen uptake was lower in the group with chronotropic incompetence, 18.3 ± 5.7 vs. 24.0 ± 5.3 mL/kg/min, p < 0.001. EC correlated positively with CI (β = 0.14, p < 0.001) and male gender (β = 5.12, p < 0.001), and negatively with age (β = −0.17, p < 0.001) and presence of heart failure (β = −3.35, p < 0.001). Beta-blocker dose was not associated with EC. Partial correlation attributable to CI accounted for more than one-third of the variance in EC explained by the model (adjusted R2 = 59.8%). Conclusions: In patients taking beta-blockers, presence of chronotropic incompetence was associated with lower EC, regardless of the beta-blocker dose. CI accounted for more than one-third of EC variance explained by our model. [ABSTRACT FROM AUTHOR]

Aerobic and resistance exercise (acute and chronic) independently and collectively induce beneficial responses in the brain that may influence memory function, including an increase in cerebral blood flow, neurogenesis, neuroelectrical alterations, and protein production. However, whether aerobic and resistance exercise improve memory via similar or distinct mechanisms has yet to be fully explained. Here, we review the unique influence of aerobic and resistance exercise on neural modulation, proteins, receptors, and ultimately, episodic memory. Resistance training may optimize neural communication, information processing and memory encoding by affecting the allocation of attentional resources. Moreover, resistance exercise can reduce inflammatory markers associated with neural communication while increasing peripheral and central BDNF (brain-derived neurotrophic factor) production. Aerobic training increases hippocampal levels of BDNF and TrkB (Tropomyosin receptor kinase B), protein kinases and glutamatergic proteins. Likewise, both aerobic and anaerobic exercise can increase CREB (cAMP response element-binding protein) phosphorylation. Thus, we suggest that aerobic and resistance exercise may influence episodic memory via similar and, potentially, distinct mechanisms. [ABSTRACT FROM AUTHOR]

Physical activity has been found to aid the maintenance of health in the elderly. Exercise-induced skeletal muscle contractions lead to the production and secretion of many small proteins and proteoglycan peptides called myokines. Thus, studies on myokines are necessary for ensuring the maintenance of skeletal muscle health in the elderly. This review summarizes 13 myokines regulated by physical activity that are affected by aging and aims to understand their potential roles in metabolic diseases. We categorized myokines into two groups based on regulation by aerobic and anaerobic exercise. With aging, the secretion of apelin, β-aminoisobutyric acid (BAIBA), bone morphogenetic protein 7 (BMP-7), decorin, insulin-like growth factor 1 (IGF-1), interleukin-15 (IL-15), irisin, stromal cell-derived factor 1 (SDF-1), sestrin, secreted protein acidic rich in cysteine (SPARC), and vascular endothelial growth factor A (VEGF-A) decreased, while that of IL-6 and myostatin increased. Aerobic exercise upregulates apelin, BAIBA, IL-15, IL-6, irisin, SDF-1, sestrin, SPARC, and VEGF-A expression, while anaerobic exercise upregulates BMP-7, decorin, IGF-1, IL-15, IL-6, irisin, and VEGF-A expression. Myostatin is downregulated by both aerobic and anaerobic exercise. This review provides a rationale for developing exercise programs or interventions that maintain a balance between aerobic and anaerobic exercise in the elderly. [ABSTRACT FROM AUTHOR]

Background: Benefits of sprint interval training performed in hypoxia (SIH) compared to normoxia (SIN) have been assessed by studies mostly conducted around 3000 m of simulated altitude. The present study aims to determine whether SIH at an altitude as high as 4000 m can elicit greater adaptations than the same training at 2000 m, 3000 m or sea-level. Methods: Thirty well-trained endurance male athletes (18–35 years old) participated in a six-week repeated sprint interval training program (30 s all-out sprint, 4 min 30 s recovery; 4–9 repetitions, 2 sessions/week) at sea-level (SL, n = 8), 2000 m (FiO2 16.7%, n = 8), 3000 m (FiO2 14.5%, n = 7) or 4000 m (FiO2 13.0%, n = 7). Aerobic and anaerobic exercise components were evaluated by an incremental exercise test, a 600 kJ time trial and a Wingate test before and after the training program. Results: After training, peak power output (PPO) during the incremental exercise test increased (~6%) without differences between groups. The lactate threshold assessed by Dmax increased at 2000 m (+14 ± 12 W) and 4000 m (+12 ± 11 W) but did not change at SL and 3000 m. Mean power during the Wingate test increased at SL, 2000 m and 4000 m, although peak power increased only at 4000 m (+38 ± 38 W). Conclusions: The present study indicates that SIH using 30 s sprints is as efficient as SIN for improving aerobic and anaerobic qualities. Additional benefits such as lactate-related adaptations were found only in SIH and Wingate peak power only increased at 4000 m. This finding is of particular interest for disciplines requiring high power output, such as in very explosive sports. [ABSTRACT FROM AUTHOR]

SuperPro Designer® is a process simulator software used for analyzing the techno-economic feasibility of large-scale bioprocesses. Its predetermined built-in features allow for easy implementation by non-experts, but a lack of examples limits its appropriation. This study aims to validate the implementation of SuperPro Designer® by non-experts for the techno-economic analysis of anaerobic digestion in Colombia, using vinasse as feedstock. These results demonstrate the financial feasibility of such a process when a processing flow rate of 25 m3/h is ensured. Additionally, this study validates the manageability of the tool for assessing the economic feasibility of a technology, a key practice during technology development regardless of the area of expertise. [ABSTRACT FROM AUTHOR]

This study was aimed at examining the impact of common types of physical efforts used to determine the aerobic and anaerobic performance of the participants on the complement system in their peripheral blood. Fifty-one physically active young males aged 16 years old (range 15–21 years) were divided into two age groups (younger, 15–17 years old and older, 18–21 years old) and performed two types of intensive efforts: aerobic (endurance; 20-m shuttle run test; Beep) and anaerobic (speed; repeated speed ability test; RSA). Venous blood samples were collected before and after each exercise (5 and 60 min) to profile the complement system components, namely the levels of C2, C3, C3a, iC3b, and C4. The endurance effort caused a decrease in the post-test C3 (p < 0.001 for both age groups) and increase in post-test C3a (p < 0.001 and p < 0.01 for the younger and older group, respectively), recovery iC3b (p < 0.001 and p < 0.05 for younger and older group, respectively), recovery C2 (p < 0.01 for both age groups), and post-test C4 (p < 0.05 and p < 0.01 for the younger and older group, respectively) levels, while the speed effort caused a decrease only in the post-test C2 (p < 0.05 for younger participants) and post-test C4 levels (p < 0.001 and p < 0.01 for the younger and older group, respectively) and an increase in the recovery C3a level (p < 0.05). Our study provides evidence that different types of physical effort promote different immune responses in physically active young men. Aerobic exercise induced the activation of an alternative pathway of the complement system, whilst the anaerobic effort had little influence. A better understanding of the post-exercise immune response provides a framework to prescribe physical activity to achieve different health outcomes. [ABSTRACT FROM AUTHOR]

Beta-alanine (BA) is a precursor to carnosine which functions as a buffer assisting in the maintenance of intracellular pH during high-intensity efforts. Rugby is a sport characterized by multiple intermittent periods of maximal or near maximal efforts with short periods of rest/active recovery. The purpose of this pilot study was to evaluate the impact of six weeks of beta-alanine supplementation on anaerobic performance measures in collegiate rugby players. Twenty-one male, collegiate rugby players were recruited, while fifteen completed post-testing (Mean ± SD; Age: 21.0 ± 1.8 years, Height: 179 ± 6.3 cm, Body Mass: 91.8 ± 13.3 kg, % Body Fat: 21.3 ± 4.4). Supplementation was randomized in a double-blind, placebo-controlled manner between 6.4 g/d of beta-alanine and 6.4 g/d of maltodextrin placebo. Body composition, upper and lower-body maximal strength and muscular endurance, intermittent sprint performance, and post-exercise lactate, heart rate, and rating of perceived exertion were assessed before and after supplementation. Data were analyzed using a 2 × 2 (group × time) mixed factorial analysis of variance (ANOVA) with repeated measures on time. No significant interaction effects were noted for body mass, fat mass, fat-free mass, and percent bodyfat (p > 0.05). No performance effects resulting from beta-alanine supplementation were detected. Results from this initial pilot investigation suggest that BA exerts little to no impact on body composition parameters, muscular strength, muscular endurance, or intermittent sprinting performance. With the limited research exploring the impact of BA in this sporting context, these initial findings offer little support for BA use, but more research is needed to fully understand the potential impact of BA on various aspects of resistance exercise performance. [ABSTRACT FROM AUTHOR]

This study aimed to examine the extent to which maturity offset, strength, and movement competency influences motor skill performance in adolescent boys. One hundred and eight secondary school boys completed anthropometric and physical testing on two non-consecutive days for the following variables: Maturity offset, isometric mid-thigh pull absolute (IMTPABS) and relative (IMTPREL) peak force, resistance training skills quotient, 10-, 20-, and 30-m sprint time, countermovement jump height, horizontal jump distance, anaerobic endurance performance, and seated medicine ball throw (SMBT). The IMTPREL displayed significant small to large correlations with all performance variables (r = 0.27–0.61), whereas maturity offset was significantly correlated with IMTPABS (r = 0.69), sprint (r = 0.29–0.33), jump (r = 0.23–0.34), and SMBT (r = 0.32). Absolute and relative strength were the strongest predictors of all performance variables and combined with maturity to explain 21%–76% of the variance. Low and average relative strength boys were nearly eight times (odds ratio: 7.80, confidence interval: 1.48–41.12, p < 0.05) and nearly four times (odds ratio: 3.86, confidence interval: 0.95–15.59, p < 0.05) more likely to be classified as lower competency compared to high relative strength boys. Relative strength has more influence on motor skill performance than maturity when compared with movement competency. [ABSTRACT FROM AUTHOR]

Lower body compression (LBC) has been shown as an effective recovery tool from basketball but it is unknown how it affects performance. The purpose of this study was to examine the effects of wearing a LBC garment on anaerobic exercise performance in collegiate basketball players. Healthy Division I collegiate basketball players (n = 12) were recruited for this study. In a crossover, counterbalanced study design, subjects volunteered to participate in two separate visits each with a different condition: wearing a LBC garment or non-compressive control (CON) garment. During each visit, subjects completed 2 × 30 second Wingate Anaerobic Tests (WAnTs) separated by a 5-min active recovery period. Each visit was separated by a 72 h washout period. Results revealed that over the 2 × 30 second WAnTs, mean power output (p = 0.028; d= 0.35), anaerobic capacity (p = 0.018; d = 0.45), and total work (p = 0.027; d = 0.36) were higher when wearing the LBC versus CON garment. However, peak power output (p = 0.319; d = 0.09), anaerobic power (p = 0.263; d = 0.23), and fatigue index (p = 0.749; d = 0.05) were not statistically different. Rating of perceived exertion (RPE) was significantly lower (p = 0.032; d = 0.72) with LBC compared to CON. Results indicate that LBC may increase anaerobic exercise performance in collegiate basketball players. [ABSTRACT FROM AUTHOR]

This study investigated relationships between shorter (505, change-of-direction (COD) deficit as a derived physical quality) and longer (Illinois agility test; IAT) COD tests with linear speed, lower-body power (multidirectional jumping), and strength in recreationally-trained individuals. Twenty-one males and 22 females (similar to collegiate club-sport and tactical athletes) were assessed in: 505 and COD deficit from each leg; IAT; 20 m sprint; vertical jump (VJ height, peak anaerobic power measured in watts (PAPw), power-to-body mass ratio); standing broad jump; lateral jump (LJ) from each leg; and absolute and relative isometric midthigh pull (IMTP) strength. Partial correlations calculated sex-determined relationships between the COD and performance tests, with regression equations calculated (p < 0.05). The 505 and IAT correlated with all tests except PAPw and absolute IMTP (r = ±0.43–0.71). COD deficit correlated with the LJ (r = −0.34–0.60). Left- and right-leg 505 was predicted by sex, 20 m sprint, and left-leg LJ (70–77% explained variance). Right-leg COD deficit was predicted by sex and left-leg LJ (27% explained variance). IAT was predicted by sex, 20 m sprint, right-leg LJ, and relative IMTP (84% explained variance). For individuals with limited training time, improving linear speed, and relative lower-body power and strength, could enhance shorter and longer COD performance. [ABSTRACT FROM AUTHOR]

Background: Visual feedback may help elicit peak performance during different types of strength and power testing, but its effect during the anaerobic Wingate test is unexplored. Therefore, the purpose of this study was to determine the effect of visual feedback on power output during a hockey-specific intermittent Wingate test (AnWT6x6) consisting of 6 stages of 6 s intervals with a 1:1 work-to-rest ratio. Methods: Thirty elite college-aged hockey players performed the AnWT6x6 with either constant (n = 15) visual feedback during all 6 stages (CVF) or restricted (n = 15) visual feedback (RVF) where feedback was shown only during the 2nd through 5th stages. Results: In the first stage, there were moderate-to-large effect sizes for absolute peak power (PP) output and PP relative to body mass and PP relative to fat-free mass. However, the remaining stages (2–6) displayed small or negligible effects. Conclusions: These data indicate that visual feedback may play a role in optimizing power output in a non-fatigued state (1st stage), but likely does not play a role in the presence of extreme neuromuscular fatigue (6th stage) during Wingate testing. To achieve the highest peak power, coaches and researchers could provide visual feedback during Wingate testing, as it may positively influence performance in the early stages of testing, but does not result in residual fatigue or negatively affect performance during subsequent stages. [ABSTRACT FROM AUTHOR]

Although reliability correlations of traditional power indices of the Wingate test have been well documented, no study has analyzed new generation power indices based on milliseconds obtained from a Peak Bike. The purpose of this study was to investigate the retest reliability of new generation power indices. Thirty-two well-trained male athletes who were specialized in basketball, football, tennis, or track and field volunteered to take part in the study (age: 24.3 ± 2.2 years; body mass: 77 ± 8.3 kg; height: 180.3 ± 6.3 cm). Participants performed two Wingate all-out sessions on two separate days. Intra-class correlation coefficient (ICC), standard error measurement (SEM), smallest real differences (SRD) and coefficient of variation (CV) scores were analyzed based on the test and retest data. Reliability results of traditional power indices calculated based on 5-s means such as peak power, average power, power drop, and fatigue index ratio were similar with the previous findings in literature (ICC ≥ 0.94; CV ≤ 2.8%; SEM ≤ 12.28; SRD% ≤ 7.7%). New generation power indices such as peak power, average power, lowest power, power drop, fatigue index, power decline, maximum speed as rpm, and amount of total energy expenditure demonstrated high reliability (ICC ≥ 0.94; CV ≤ 4.3%; SEM ≤ 10.36; SRD% ≤ 8.8%). Time to peak power, time at maximum speed, and power at maximum speed showed a moderate level of reliability (ICC ≥ 0.73; CV ≤ 8.9%; SEM ≤ 63.01; SRD% ≤ 22.4%). The results of this study indicate that reliability correlations and SRD% of new generation power and fatigue-related indices are similar with traditional 5-s means. However, new time-related indices are very sensitive and moderately reliable. [ABSTRACT FROM AUTHOR]