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This paper addresses the facility location problem under a mill pricing policy, integrating customers' behavior through the concept of preferences. The problem is modeled as a bilevel optimization problem, where the existence of ties in customers' preferences can lead to an ill-posed bilevel problem due to the possible existence of multiple optima to the lower-level problem. As the commonly employed optimistic and pessimistic strategies are inadequate for this problem, a specific approach is proposed bearing in mind the customers' rational behavior. In this work, we propose a novel formulation of the problem as a bilevel model in which each customer faces a lexicographic biobjective problem in which the preference is maximized and the total cost of accessing the selected facility is minimized. This allows for a more accurate representation of customer preferences and the resulting decisions regarding facility location and pricing. To address the complexities of this model, we apply duality theory to the lower-level problems and, ultimately, reformulate the bilevel problem as a single-level mixed-integer optimization problem. This reformulation incorporates big-M constants, for which we provide valid bounds to ensure computational tractability and solution quality. The computational study conducted allows us to assess, on the one hand, the effectiveness of the proposed reformulation to address the bilevel model and, on the other hand, the impact of the length of the customer preference lists and fixed opening cost for facilities on the computational time and the optimal solution. [ABSTRACT FROM AUTHOR]

Optimizing the use of existing high-voltage transmission lines demands real-time condition monitoring to ensure structural integrity and continuous service. Operating these lines at the current capacity is limited by safety margins based on worst-case weather scenarios, as exceeding these margins risks bringing conductors dangerously close to the ground. The integration of optical fibers within modern transmission lines enables the use of Distributed Fiber Optic Sensing (DFOS) technology, with Chirped-Pulse Phase-Sensitive Optical Time-Domain Reflectometry (CP- Φ OTDR) proving especially effective for this purpose. CP- Φ OTDR measures wind-induced vibrations along the conductor, allowing for an analysis of frequency-domain vibration modes that correlate with conductor length and sag across spans. This monitoring system, capable of covering distances up to 40 km from a single endpoint, enables dynamic capacity adjustments for optimized line efficiency. Beyond sag monitoring, CP- Φ OTDR provides robust detection of external threats, including environmental interference and mechanical intrusions, which could compromise cable stability. By simultaneously monitoring the Optical Phase Conductor (OPPC) and Optical Ground Wire (OPGW), this study offers the first comprehensive, real-time evaluation of both structural integrity and potential external aggressions on overhead transmission lines. The findings demonstrate that high-frequency data offer valuable insights for classifying mechanical intrusions and environmental interferences based on spectral content, while low-frequency data reveal the diurnal temperature-induced sag evolution, with distinct amplitude responses for each cable. These results affirm CP- Φ OTDR's unique capacity to enhance line safety, operational efficiency, and proactive maintenance by delivering precise, real-time assessments of both structural integrity and external threats. [ABSTRACT FROM AUTHOR]

This article draws on the stimulus–organism–response (SOR) model to understand the role of negative emotions in the anti-brand behaviors of online users who consume snow sports brands. To this end, both the online social influence and the mediating effect of symbolic incongruence (stimulus) on the generation of negative emotions (anger, stress, frustration, fear, boredom and sadness) (organism), and how these influence the formation of negative customer brand engagement (nCBE) (response), are analyzed. The study also analyses the moderating effects of "level of expertise", this makes it possible to capture differences in behaviors based on the profile of the users in each of the proposed relationships. Questionnaire responses of 400 ski and snowboard users over 18 years of age were analyzed using a quantitative methodology. The results obtained have important theoretical and practical implications, since they confirm that online social influences have both a direct and indirect (mediating) effect on negative emotions, which positively affects the nCBE of online users of snow sports brands. Significant differences in behavior based on experience level (moderation effect) were also found. The study proposes useful practical recommendations applicable in online environments that the extreme sports industry could use to neutralize/avoid highly detrimental consequences. [ABSTRACT FROM AUTHOR]

This document is an editorial for a special issue of the journal Processes on the topic of Computational Fluid Dynamics (CFD) applications in energy engineering research and simulation. The editorial highlights the significant progress made in CFD over the past few decades, with advancements in numerical methods, physical models, and computer technology. CFD is now widely used in both industry and academia, with a range of applications in energy engineering, such as power generation, wind energy, and fuel cells. The special issue covers various topics, including rotating machinery, oil and gas applications, and novel technologies. Contributions come from 22 countries, with notable contributions from China, the USA, Korea, Mexico, and Spain. The editorial concludes by mentioning specific research articles that have the potential to further advance CFD in energy engineering applications. [Extracted from the article]

This study aims to determine whether post-hospitalization psychological distress is associated with exercise capacity, physical function and health status in COVID-19 survivors. In this observational study, hospitalized COVID patients were included and divided into two groups according to the mental component summary subscale of the 12-item Short-Form Health Survey. Patients with a score ≤ 45 were included in the psychological distress group, and patients with a score > 45 were included in the non-psychological distress group. The main variables were exercise capacity, physical function, and health status. Patients were evaluated at discharge, 3 months, and at 6 months follow-up. Finally, a total of 60 patients were included in the study. Significant differences were found in exercise capacity, physical function, and health status (p < 0.05), with worse results in the group with psychological distress at discharge and 3 months follow-up. At 6 months after discharge, COVID patients with psychological distress exhibited worse results in exercise capacity, physical function, and health status, being significant exercise capacity and physical function (p < 0.05). It can be concluded that COVID patients with psychological distress at hospital discharge reported worse exercise capacity, physical function and health status at hospital discharge, 3 months and 6 months follow-up. [ABSTRACT FROM AUTHOR]

A rich tradition of studies on languages with differential object marking (DOM) is available in the literature. Languages like Spanish or Romanian are frequently cited in discussions about DOM, but Valencian is seldom mentioned in this context. This oversight may stem from a lack of familiarity with the Valencian language and an over-reliance on guidelines set by textbooks and official prescriptive grammars—in the case of Valencian, by the Acadèmia Valenciana de la Llengua—which drafts the linguistic regulations of the Valencian language. This study aimed to analyze the usage of the DOM in Valencian and explore the social variables that help explain this usage (sex, age, and education). To achieve this goal, Spanish–Valencian bilingual participants completed an oral production task to evaluate their use of DOM in Valencian. Statistical analysis revealed that Valencian is a DOM language that marks direct objects that refer to humans and definite entities. These results point to the linguistic ideologies in Valencia that attempt to artificially create linguistic differentiation between Valencian and Spanish, the co-official languages in the region. Furthermore, the results emphasize the limitations of top-down prescriptive policies in modifying vernacular linguistic varieties. [ABSTRACT FROM AUTHOR]

The introduction of exoskeletons in industry has focused on improving worker safety. Exoskeletons have the objective of decreasing the risk of injury or fatigue when performing physically demanding tasks. Exoskeletons' effect on the muscles is one of the most common focuses of their assessment. The present study aimed to analyze the muscle interactions generated during load-handling tasks in laboratory conditions with and without a passive lumbar exoskeleton. The electromyographic data of the muscles involved in the task were recorded from twelve participants performing load-handling tasks. The correlation coefficient, coherence coefficient, mutual information, and multivariate sample entropy were calculated to determine if there were significant differences in muscle interactions between the two test conditions. The results showed that muscle coordination was affected by the use of the exoskeleton. In some cases, the exoskeleton prevented changes in muscle coordination throughout the execution of the task, suggesting a more stable strategy. Additionally, according to the directed Granger causality, a trend of increasing bottom-up activation was found throughout the task when the participant was not using the exoskeleton. Among the different variables analyzed for coordination, the most sensitive to changes was the multivariate sample entropy. [ABSTRACT FROM AUTHOR]

Simple Summary: Advances in malignant pleural mesothelioma research have led to the approval of first-line immunotherapies and the development of numerous trials of new first-line treatment regimens. Knowledge of predictive factors of response to treatments could help identify patients who benefit from treatments. The purpose of this review is to describe the state of the art in the treatment of patients with MPM at present. Malignant pleural mesothelioma (MPM) is a locally aggressive disease related to asbestos exposure with a median survival for untreated patients of 4–8 months. The combination of chemotherapy based on platinum and antifolate is the standard treatment, and the addition of bevacizumab adds two months to median survival. Recently, in first-line treatment, immunotherapy combining nivolumab with ipilimumab has been shown to be superior to chemotherapy in the CheckMate-743 study in terms of overall survival (18.1 months), leading to its approval by the FDA and EMA. The positive results of this study represent a new standard of treatment for patients with MPM; however, not all patients will benefit from immunotherapy treatment. In an effort to improve the selection of patient candidates for immunotherapy for different tumors, biomarkers that have been associated with a greater possibility of response to treatment have been described. MPM is a type of tumor with low mutational load and neo-antigens, making it a relatively non-immunogenic tumor for T cells and possibly less susceptible to responding to immunotherapy. Different retrospective studies have shown that PD-L1 expression occurs in 20–40% of patients and is associated with a poor prognosis; however, the predictive value of PD-L1 in response to immunotherapy has not been confirmed. The purpose of this work is to review the state of the art of MPM treatment in the year 2023, focusing on the efficacy results of first-line or subsequent immunotherapy studies on patients with MPM and possible chemo-immunotherapy combination strategies. Additionally, potential biomarkers of response to immunotherapy will be reviewed, such as histology, PD-L1, lymphocyte populations, and TMB. [ABSTRACT FROM AUTHOR]

Advances in research on environmental problems and public awareness of them have led to renewed concern about the need to establish mechanisms and figures to protect and manage sites so that geoecological processes remain outside the dynamics of anthropic occupation. This research has been approached from an inductive and qualitative perspective based on case studies to examine the articulation of the Spanish geoparks, their dynamics, and the experiences of private valorization in them. Geological heritage is seen as a lever for the promotion of the territory. In all cases, although the geological–geomorphological–paleontological–environmental resources must be significant, this designation aims to enhance the value of all assets, both natural and cultural, conceiving the geopark not as a figure of environmental protection but as a "figure to promote local development". A total of 48 land stewardship initiatives were identified in 11 of the 15 Spanish geoparks. The most significant presence of initiatives was found in the geoparks of Catalonia, followed by the Lanzarote Geopark. No nature-based schools are located within geoparks, except for Wild Me in Central Catalonia. However, the presence of nature-based schools in biosphere reserves (BRs) seems to be more common. Framing alternative proposals, such as nature-based schools in these areas and using land stewardship in their operation, can become an opportunity to protect a region's geological and cultural heritage and improve local communities' quality of life through sustainable and responsible economic and tourism activities. Early-years education in the natural environment facilitates the acquisition of long-term pro-environmental skills, competencies, and behaviors that last into adulthood and act as multipliers for others. [ABSTRACT FROM AUTHOR]

Simple Summary: Recently immunotherapy has been approved in first line for patients with MPM. However, the benefit of immunotherapy in MPM is modest, and recognizing the immune landscape of this tumor could guide the optimal therapeutic strategy. In some tumors dynamic changes of TILs has been reported after chemotherapy, endocrine therapy and immunotherapy. We investigated the changes in expression of TILs in human MPM tumor tissue using immunohistochemistry and patterns of gene expression from paired samples. We included samples of patients treated with chemotherapy, immunotherapy and patients without any treatment between the samples. In our series, after systemic treatment or at progressive disease we observed a decrease of the number of TILs and a downregulation of the immune-related genes. In patients without any treatment between the samples we found an increase of immune cells. We suggest that the immune system tends to turn off during the evolution of disease of after treatment. MPM is an aggressive disease with an immunosuppressive tumor microenvironment, and interest in exploring immunotherapy in this disease has been increasing. In the first line of treatment, the combination of nivolumab and ipilimumab demonstrated an improvement in survival over chemotherapy. The presence of TILs has been recognized as a marker of antitumor immune response to chemotherapy in solid tumors. The aim of our study is to identify the effect of treatment on immune cells and the immune gene profile in MPM. We investigated the changes in expression of TILs in 10 human MPM paired tumor tissues using immunohistochemistry and gene expression analysis from paired untreated and treated samples. In this small series, we demonstrated that during the evolution of disease without any treatment there was an increase in the inflammatory component in tumor samples. After systemic treatment there was a decrease in the number of TILs. We observed that after systemic treatment or disease progression immune gene signatures were suppressed. Our integrated analysis of paired samples with immune profile and genomic changes on MPM suggested that during the evolution of the disease the immune system tends to switch, turning off with treatment. [ABSTRACT FROM AUTHOR]

This review focuses on analysing the strategy and aspirations of the European Union within the hydrogen sector. This aim is achieved through the examination of the European Parliament's hydrogen strategy, allowing for a study of actions and projects in hydrogen technologies. The Parliament's hydrogen strategy is the document that provides the guideline of how the EU intends to function in the hydrogen sector and manages to cover a wide range of topics, all of them significant to represent the entirety of the hydrogen sector. It touches on subjects such as hydrogen demand, infrastructure, research, and standards, among others. The review discusses also the aspect that the EU intends to be a leader in the hydrogen sector, including the large-scale industrialization of key elements such as electrolysers, and this purpose is corroborated by the large number of associations, strategies, plans, and projects that are being established and developed by the European Union. The most important conclusions to learn from this analysis are that hydrogen has many of the right characteristics to make it the key to decarbonisation, especially in hard-to-abate sectors, and that it is bound to be one of the main actors in the imminent green transition. Moreover, hydrogen seems to be having its breakthrough, and this field's development can have benefits not only from an environmental perspective but also from an economical one, enabling the way into the green transition and the fight against climate change. [ABSTRACT FROM AUTHOR]

Regenerative endodontic treatment (RET) has been considered a reliable procedure to treat immature necrotic teeth; however, the effect of dental trauma on the prognosis of RET is questionable. This systematic review aimed to evaluate the current level of evidence for revascularization techniques (the RET) in the management of traumatized necrotic immature permanent teeth with or without periapical radiolucent areas. Four electronic databases—PubMed, Web of Science, Scopus, and Embase—were searched until November 2022. Only randomized clinical trials, cohort studies, and case-control studies with a minimum of 10 cases and 12 months of follow-ups were included. The search identified 363 preliminary results. After discarding the duplicates and screening the titles, abstracts, and full texts, 13 articles were considered eligible. The results showed that RET techniques seemed to have high survival and success rates, 93.8% and 88.3%, respectively, in the treatment of traumatized necrotic immature permanent teeth. Root maturation with RET techniques seemed to be lower in traumatized teeth. Future studies are needed to evaluate root maturation in traumatized teeth using 3-dimensional radiographic evaluations. In addition, the lack of literature on the studies comparing RET and apexification (calcium hydroxide or an MTA) in the treatment of traumatized necrotic immature teeth highlights the necessity for high-level clinical studies comparing these treatment modalities. [ABSTRACT FROM AUTHOR]

The animal-powered waterwheels of the meandering River Medjerda in Testour, a Tunisian town of Moorish foundation, are compared with those in the alluvial plain of the River Júcar in the region of Ribera Alta (Valencia, Spain). The methodology used in this research is qualitative-analytical and based on the comparative study of groundwater catchment systems on Mediterranean alluvial plains. The environmental characteristics (geological, climatic, hydrological and hydrogeomorphic) of both sectors are analysed to confirm the environmental similarities between both sites. The location and characteristics of these systems have also been analysed, including aspects such as technological evolution and current status, as well as their coexistence with other traditional irrigation systems. The similarity in the location, characteristics, and state of the systems in the two chosen sectors is confirmed, as well as the near absence of significant differences. For this reason, the work highlights the importance of environmental factors as opposed to cultural factors in the use and location of waterwheels. [ABSTRACT FROM AUTHOR]

As part of the European Commission research project DIY4U focused on the development of machinery to be installed in supermarket allowing customers to define their customized detergent according to their needs. These machines will mix the detergent components (surfactant, fatty acid, water, perfume, etc.) already in the detergent canister as sold to consumers. To avoid long waiting times for customers, and to obtain a product with good quality and consistency, mixing must be very efficient. A mixing process with rotation and displacement by means of rotating the canister around an axis below the canister bottom has been checked by means of Computational Fluid Dynamics (CFD) tools after validation of one case with lab results. This is a new approach for liquid detergents, as commonly is a powder detergent production process. The mixing process has been simulated for 39 different combinations of components mass fraction percentages and the mixing quality observed during the mixing period. A response surface obtained from these simulations has been developed to be included in a Digital Twin, this being a task within this DIY4U project. The results show that this system is very efficient, taking a few seconds to develop a complete mixing. Also, the mixing time differences are quite small, requiring all customers to wait just few seconds independently of their detergent formulation. [ABSTRACT FROM AUTHOR]

The aim of this study was to determine the association between the mother's periodontal condition and perinatal complications, such as preterm birth (PTB) and/or low birth weight (LBW), in a cohort of women in Valencia, Spain. Other related factors, such as tobacco, were also analysed. A prospective cohort study was carried out in a sample of 102 women with a single foetus and ages ranging between 18 and 42 years. Sociodemographic and obstetric variables, caries status, percentage of bleeding, clinical attachment loss (CAL), and probing pocket depth (PPD) data have been collected and analysed. The mean age was 32.4 years, and the BMI was normal. The average weight of new-borns (NB) was 3034 g. A total of 9.8% of the women smoked during their pregnancy. Bleeding percentage was 16.43% (SD 14.81%) and PPDs > 3 mm 8.8 (SD 11.08). The mean of CAL > 0 mm was 1.14 (SD 2.83). The frequency of PTB and LBW was 26%. No statistically significant differences were found between probing depth > 3 mm or CAL > 1 mm, with PTB and/or LBW. Periodontal disease in the mother was not statistically significantly related to either PTB or LBW. Tobacco use during pregnancy showed a statistical significance linked to LBW, but not with PTB. [ABSTRACT FROM AUTHOR]

Background: Mycobacterium avium subsp. paratuberculosis (MAP) is the causal agent of paratuberculosis. This pathogen is able to survive adverse environmental conditions, including the pasteurization process. Copper, a well-studied metal, is considered an important antibacterial tool, since it has been shown to inactivate even MAP in treated milk through unknown mechanisms. The aim of the present study is to show the effect of copper ions, and reactive oxygen species (ROS) generated in response to oxidative stress, on the damage to MAP DNA when exposed to a copper ion challenge in cow's milk. Methodology: Spiked milk with different MAP bacterial loads was supplemented with blocking agents. These were either the copper chelators ethylenediaminetetraacetic acid (EDTA) and batocuproin (BCS) or the ROS quenchers D-mannitol, gallic acid and quercetin. The DNA protection, MAP viability and ROS production generated after exposure to a copper challenge were then measured. Results: In a bacterial load of 104 cells mL−1, blocking effects by both the copper chelators and all the ROS quenchers offered significant protection to MAP DNA. In a concentration of 102 cells mL−1, only D-mannitol and a mix of quenchers significantly protected the viability of the bacteria, and only at a concentration of 106 cells mL−1 was there a lower production of ROS when supplementing milk with gallic acid, quercetin and the mix of quenchers. Conclusion: Based on these findings, it may be concluded that MAP DNA damage can be attributed to the combined effect of the direct copper ions and ROS generated. Nevertheless, taking into account the antioxidant environment that milk provides, the direct effect of copper could play a prominent role. [ABSTRACT FROM AUTHOR]

(1) Background: For normo-nourished colorectal cancer patients, the need for immunonutrients after elective surgery is not known. (2) Methods: Multicenter, randomized, double-blind, phase III clinical trial comparing the postoperative diet with 200 mL oligomeric hyperproteic normocaloric (OHN; experimental arm) supplement vs. 200 mL immunonutritional (IN) (active comparator) supplement twice a day for five days in 151 normo-nourished adult colorectal-resection patients following the multimodal rehabilitation ERAS protocol. The proportions of patients with complications (primary outcome) and those who were readmitted, hospitalized for <7 days, had surgical site infections, or died due to surgical complications (secondary outcome) were compared between the two groups until postoperative day 30. Tolerance to both types of supplement and blood parameters was also assessed until day 5. (3) Results: Mean age was 69.2 and 84 (58.7%) were men. Complications were reported in 41 (28.7%) patients and the incidence did not differ between groups (18 (25%) vs. 23 (32.4%) patients with OHN and IN supplement, respectively; p = 0.328). No significant differences were found for the rest of the variables. (4) Conclusions: IN supplement may not be necessary for the postoperative recovery of colorectal cancer patients under the ERAS regimen and with normal nutritional status at the time of surgery. [ABSTRACT FROM AUTHOR]

Manual material handling tasks in industry cause work-related musculoskeletal disorders. Exoskeletons are being introduced to reduce the risk of musculoskeletal injuries. This study investigated the effect of using a passive lumbar exoskeleton in terms of moderate ergonomic risk. Eight participants were monitored by electromyogram (EMG) and motion capture (MoCap) while performing tasks with and without the lumbar exoskeleton. The results showed a significant reduction in the root mean square (VRMS) for all muscles tracked: erector spinae ( 8 % ), semitendinosus ( 14 % ), gluteus ( 5 % ), and quadriceps ( 10.2 % ). The classic fatigue parameters showed a significant reduction in the case of the semitendinosus: 1.7 % zero-crossing rate, 0.9 % mean frequency, and 1.12 % median frequency. In addition, the logarithm of the normalized Dimitrov's index showed reductions of 11.5, 8, and 14% in erector spinae, semitendinosus, and gluteus, respectively. The calculation of range of motion in the relevant joints demonstrated significant differences, but in almost all cases, the differences were smaller than 10 % . The findings of the study indicate that the passive exoskeleton reduces muscle activity and introduces some changes of strategies for motion. Thus, EMG and MoCap appear to be appropriate measurements for designing an exoskeleton assessment procedure. [ABSTRACT FROM AUTHOR]

In this study, we compare the efficacy and diagnostic concordance of the ICDAS, the radiographic criterion and the instrument known as the DIAGNOdent fluorescence laser pen on occlusal caries lesions using a histological section as the gold standard. Of 100 teeth that did not present cavitated occlusal lesions or occlusal fillings, 80 were chosen through a randomization program and examined by two previously trained and calibrated researchers. Subsequently, the teeth were sectioned with a diamond disk and observed under an optical microscope. The results were studied for caries with a limit established in enamel and caries with extension to dentin. The intra-examiner (0.821–0.933) and inter-examiner (0.817–0.924) reproducibility obtained for both ICDAS and DIAGNOdent for the diagnosis of borderline enamel caries was high. Similarly, intra-examiner (0.686–1.000) and inter-examiner (0.809–0.944) reproducibility for diagnosis of caries with dentin extension was also high for both methods. The sensitivity obtained was 0.76 (ICDAS), 0.87 (DIAGNOdent) and 0.58 (Rx), whereas the specificity obtained was 0.66 (ICDAS), 0.4 (DIAGNOdent) and 0.77 (Rx) for lesions limited to enamel. For lesions with extension to dentin, the sensitivity obtained was 0.73 (ICDAS), 0.82 (DIAGNOdent) and 0.09 (Rx), and the specificity obtained was 0.79 (ICDAS), 0.52 (DIAGNOdent) and 0.97 (Rx). Sensitivity increases in both cases by combining diagnostic methods. In conclusion, ICDAS and DIAGNOdent are better diagnostic methods than Rx for the detection of occlusal caries, and the combination of these methods helps to obtain a better diagnosis. [ABSTRACT FROM AUTHOR]

Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were assessed using the EUCAST E.Def 7.3.2 broth dilution method. Fluconazole-resistant C. parapsilosis isolates (FRCP) were studied for sequencing of the ERG11 gene. The incidence of candidemia and C. parapsilosis bloodstream infection increased significantly in the pandemic period (p = 0.021). ICU admission, mechanical ventilation, parenteral nutrition and corticosteroids administration were more frequent in patients with candidemia who had been admitted due to COVID-19. Fifteen cases of FRCP fungemia were detected. The first case was recorded 10 months before the pandemic in a patient transferred from another hospital. The incidence of FRCP in patients admitted for COVID-19 was 1.34 and 0.16 in all other patients (p < 0.001). ICU admission, previous Candida spp. colonization, arterial catheter use, parenteral nutrition and renal function replacement therapy were more frequent in patients with candidemia due to FRCP. All FRCP isolates showed the Y132F mutation. In conclusion, the incidence of candidemia experienced an increase during the COVID-19 pandemic and FRCP fungemia was more frequent in patients admitted due to COVID-19. [ABSTRACT FROM AUTHOR]

This paper addresses a biobjective bus routing problem that pays attention to both the routing cost and the total distance walked by the individuals to reach their assigned pickup point. These two objectives are conflicting. Generally, the less the individuals walk, the more the number of visited pickup points and so the more the routing cost. In addition, the problem deals with finding the set of pickup points visited among the set of potential locations, identifying the set of individuals assigned to each visited pickup point, and designing the bus routes. Taking into account the highly combinatorial nature of the problem, an evolutionary algorithm is proposed to approach the associated Pareto front. Its main novelties are twofold. The first is the way in which the chromosomes are encoded since they only provide information about the number of routes and the visited pickup points. The second novelty lies in the procedure to construct a feasible solution from the chromosome, which involves a heuristic and several local search procedures to improve both objective functions. Computational experiments are carried out to check the performance of the algorithm in terms of the quality of the Pareto front yielded. [ABSTRACT FROM AUTHOR]

Salinas and saltscapes are relevant geoheritage sites with important implications on socioeconomic activities beyond the production of salt, particularly tourism and education. As cultural landscapes, they also have implications related to the identity of their communities. This work presents the study of the patrimonialization processes of four sites in Europe (Añana in Spain, Guérande in France, Læsø in Denmark, and Sečovlje in Slovenia). Lessons obtained from these processes may contribute to the recovery and valuation of similar saltscapes and other forms of geoheritage. The study is based on interviews with relevant stakeholders, a survey of the related grey and scientific literature, and a simplified SWOT analysis. Despite their differences in historical background and current management, all four sites share features that have contributed to the success of their patrimonialization processes, such as having a dedicated entity for this purpose or being protected in some way. They also share common threats that need to be addressed, such as the banalization of the heritage discourse. Other saltscapes and geoheritage sites in general may benefit from these common features, which should serve as an inspiration and not as a template. In the end, shifting from a little-known productive, (proto-)industrial activity toward a sustainable, multifunctional landscape in which geoeducation and tourism are paramount contributes to a more resilient and educated society. [ABSTRACT FROM AUTHOR]

Featured Application: This work has direct application in live automatic captioning of audiovisual material, which is fundamental in accessibility. This paper describes the automatic speech recognition (ASR) systems built by the MLLP-VRAIN research group of Universitat Politècnica de València for the Albayzín-RTVE 2020 Speech-to-Text Challenge, and includes an extension of the work consisting of building and evaluating equivalent systems under the closed data conditions from the 2018 challenge. The primary system (p-streaming_1500ms_nlt) was a hybrid ASR system using streaming one-pass decoding with a context window of 1.5 seconds. This system achieved 16.0% WER on the test-2020 set. We also submitted three contrastive systems. From these, we highlight the system c2-streaming_600ms_t which, following a similar configuration as the primary system with a smaller context window of 0.6 s, scored 16.9% WER points on the same test set, with a measured empirical latency of 0.81 ± 0.09 s (mean ± stdev). That is, we obtained state-of-the-art latencies for high-quality automatic live captioning with a small WER degradation of 6% relative. As an extension, the equivalent closed-condition systems obtained 23.3% WER and 23.5% WER, respectively. When evaluated with an unconstrained language model, we obtained 19.9% WER and 20.4% WER; i.e., not far behind the top-performing systems with only 5% of the full acoustic data and with the extra ability of being streaming-capable. Indeed, all of these streaming systems could be put into production environments for automatic captioning of live media streams. [ABSTRACT FROM AUTHOR]

Hospital environments are facing new challenges this century. One of the most important is the quality of services to patients. Social robots are gaining prominence due to the advantages they offer; in particular, several of their main uses have proven beneficial during the pandemic. This study aims to shed light on the current status of the design of social robots and their interaction with patients. To this end, a systematic review was conducted using WoS and MEDLINE, and the results were exhaustive analyzed. The authors found that most of the initiatives and projects serve the elderly and children, and specifically, that they helped these groups fight diseases such as dementia, autism spectrum disorder (ASD), cancer, and diabetes. [ABSTRACT FROM AUTHOR]

computational fluid dynamics (CFD) analysis of air distribution in a representative railway vehicle equipped with a heating, ventilation, air conditioning (HVAC) system is presented in this paper. Air distribution in the passenger's compartment is a very important factor to regulate temperature and air velocity in order to achieve thermal comfort. A complete CFD model, including the car's geometry in detail, the passengers, the luminaires, and other the important features related to the HVAC system (air supply inlets, exhaust outlets, convectors, etc.) are developed to investigate eight different typical scenarios for Northern Europe climate conditions. The results, analyzed and discussed in terms of temperature and velocity fields in different sections of the tram, and also in terms of volumetric parameters representative of the whole tram volume, show an adequate behavior from the passengers' comfort point of view, especially for summer climate conditions. [ABSTRACT FROM AUTHOR]

Background: Scientific evidence is scarce for the antimicrobial effect of copper on bacteria characterized as more resistant. Using Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant microorganism, as a pathogen model, copper ion treatment has shown a significant bactericidal effect; however, the sustainability of MAP against copper toxicity was also reported in several studies. Accordingly, the present study aimed to evaluate the impacts of copper on MAP. Methodology: This study considered physicochemical properties and copper concentration in a buffer since it could modulate MAP response during the application of copper treatment. Results: Despite the efficacy of copper ions in significantly reducing the MAP load in Phosphate Buffered Saline, some MAP cells were able to survive. The copper concentration generated by the copper ion treatment device increased significantly with increasing exposure times. MAP bacterial load decreased significantly when treated with copper ions as the exposure times increased. An increase in pH decreased oxygen consumption, and an increase in conductivity was reported after treatment application. Conclusions: Even with higher concentrations of copper, the efficacy of MAP control was not complete. The concentration of copper must be a key element in achieving control of highly resistant microorganisms. [ABSTRACT FROM AUTHOR]