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Hydrogen fuel cell vehicles (HFCVs) represent an important breakthrough in the hydrogen energy industry. The safe utilization of hydrogen is critical for the sustainable and healthy development of hydrogen fuel cell vehicles. In this study, risk factors and preventive measures are proposed for on-board hydrogen systems during the process of transportation, storage, and use of fuel cell vehicles. The relevant hydrogen safety standards in China are also analyzed, and suggestions involving four safety strategies and three safety standards are proposed. [ABSTRACT FROM AUTHOR]

Background: In the diasporic eastern coastal region of China, leftover children are a unique group of children; their social adaptation challenges are more prominent due to transnational separation from parents. This study explores the relationship between parent-offspring communication and school adaptation among leftover children. Methods: We administered questionnaires to 957 children from six schools in June and December of 2022. All students in the sample were randomly selected from within the classrooms. In total, 561 (47.95% female, mean age = 12.84, SD = 0.95) of them were leftover children. Self-report questionnaires on communication with their parents, school adaptation, companionship, and feelings of safety were used in this investigation We subsequently used SPSS software and the PROCESS plugin to analyze the relationships between variables. Results: A significant and positive relationship was found between parent-offspring communication and school adaptation in leftover children. Companionship mediated this effect. Additionally, the impact of parent-offspring communication on companionship was moderated by a sense of safety. Conclusions: The study concluded that parent-offspring communication, school adaptation, companionship, and a sense of safety were all positively correlated. In addition, companionship partially mediated the relationship between parent-offspring communication and school adaptation. Moreover, a sense of safety played a moderating role. These conclusions can provide empirical support for improving the school adaptation of leftover children. [ABSTRACT FROM AUTHOR]

The present study was conducted to analyze the level of four priority polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), chrysene (Chr), benzo[a]anthracene (BaA), and benzo[b]fluoranthene (BbF), in traditionally smoked chicken products marketed in China. The results show that the amount of ƩPAH4 (the sum of four different PAHs: BaP, Chr, BaA, and BbF) was 30.43–225.17 and 18.75–129.54 µg/kg in the skin and meat of smoked chicken products, respectively. The content of ƩPAH4 in the smoked skin was significantly higher as compared to the smoked meat (p < 0.05). The calculation of MOE (margin of exposure) results suggested the possibilities of ingestion risk associated with the consumption of smoked chicken skin. Furthermore, the formaldehyde content in the skin of smoked chicken was 2.17–6.84 mg/kg and 0.86–2.95 mg/kg in the smoked meat. These results indicate that optimization or alternative methods for food processing should be developed to reduce the high level of harmful substances formed during processing to ensure the safety of smoked chicken products. Moreover, along with harmful substances, the moisture content and color of traditionally smoked chicken were analyzed to provide a practical reference for healthy, safe and green processing technology for smoked chicken. [ABSTRACT FROM AUTHOR]

Simple Summary: Afatinib has been approved for patients with lung cancer carrying uncommon epidermal growth factor receptor gene (EGFR) mutations. Dacomitinib, another second-generation inhibitor, has also shown promising potential for these mutations. This is the first and largest comparative study on second-generation inhibitors in patients with uncommon EGFR mutations to date. We found that dacomitinib demonstrated a more favorable activity with manageable toxicity compared with afatinib, which provided more evidence for dacomitinib application in this setting. (1) Background: Afatinib has been approved for patients with non-small cell lung cancer (NSCLC) carrying major uncommon epidermal growth factor receptor gene (EGFR) mutations. Dacomitinib, another second-generation tyrosine kinase inhibitor, has also shown promising potential for uncommon EGFR mutations. However, no comparative study has been conducted. (2) Methods: Two cohorts were employed: the AFANDA cohort, an ambispective cohort including 121 patients with uncommon EGFR mutations admitted to two tertiary hospitals in China, and an external validation afatinib cohort (ex-AC), extracted from the Afatinib Uncommon EGFR Mutations Database (N = 1140). The AFANDA cohort was divided into an afatinib cohort (AC) and a dacomitinib cohort (DC) for internal exploration. Objective response rate (ORR), progression-free survival (PFS), and adverse events (AEs) were assessed for comparison. Progression patterns and resistance mechanisms were explored. (3) Results: In total, 286 patients with advanced NSCLC carrying uncommon EGFR mutations treated with afatinib or dacomitinib were enrolled, including 79 in the AFANDA cohort (44 in the DC, 35 in the AC) and 207 in the ex-AC. In internal exploration, the ORR of the DC was significantly higher than that of the AC (60.5 vs. 26.7%, p = 0.008), but there was no significant difference in median PFS between the DC and the AC (12.0 months vs. 10.0 months, p = 0.305). Multivariate analysis confirmed an independent favorable effect of dacomitinib on PFS (hazard ratio (HR), 1.909; p = 0.047). In external validation, multivariate analysis confirmed the independent prognostic role of dacomitinib in PFS (HR, 1.953; p = 0.029). Propensity score matching analysis confirmed the superiority of dacomitinib over afatinib in terms of PFS in both univariate and multivariate analyses. Toxicity profiling analysis suggested more G1 (p = 0.006), but fewer G3 (p = 0.036) AEs in the DC than in the AC. Progression patterns revealed that the incidence of intracranial progression in the AC was significantly higher than that in the DC (50 vs. 21.1%, p = 0.002). Drug resistance analysis indicated no significant difference in the occurrence of T790M between the AC and the DC (11.8 vs. 15.4%, p = 0.772). (4) Conclusions: Compared with afatinib, dacomitinib demonstrated a more favorable activity with manageable toxicity and different progression patterns in patients with NSCLC carrying uncommon EGFR mutations. [ABSTRACT FROM AUTHOR]

Subway transportation is one of the most prevalent urban transportation methods globally. Millions of people around the globe use this medium as their mode of transportation daily. However, subway stations may be highly prone to fire, smoke, or explosion accidents. The safety of people using subway stations demands a robust and practical framework to assess fire hazards and risks. This study provides a methodology to assess fire risk at a subway station. This study integrates fault tree analysis (FTA) and fuzzy analysis to conduct a comprehensive fire risk assessment. An integrated numerical model of fire temperature and fatality rate was developed using probit correlations for various fire exposure scenarios. The fire dynamics simulator (FDS) provides the probability distribution of casualties caused by fire. To demonstrate the operationalization of the model, Line 1 of the Harbin Metro, located in China, is used as a case study. Results show a probability of 42% of having fire risk in the subway station. Results reveal the highest fatality rate is 6.2% when evacuation time exceeds 200 s. The research helps us to understand the spread of smoke and temperature distribution due to a fire in a subway station. This study is helpful for fire protection engineers, safety managers, and local fire departments to develop a contingency plan to deal with fire in a subway station. [ABSTRACT FROM AUTHOR]

The risk of ship–bridge collisions should be evaluated using advanced models to consider different anti-collision and bridge-protection measures. This study aimed to propose a method to evaluate the effectiveness of active and passive safety measures in preventing ship–bridge collision. A novel ship–bridge collision probability formulation taking into consideration different safety measures was proposed. The model was applied at Jintang Bridge in China where the surrounding vessel traffic is ultra-crowded. We calculated the collision probability between the bridge and passing traffic using automatic identification system (AIS) data, Monte Carlo simulation, and Bayesian networks. Results under four different safety measures (i.e., active measures, passive measures, both measures and none) were analyzed and compared. The analysis concluded that both active and passive safety measures are effective in reducing the ship–bridge collision probability. Active measures, if deployed properly, can provide protection at an equivalent level than passive measures against collision risks. However, passive measures, such as setting arresting cables, are necessary in cases where the response time of the active measures is long. The proposed method and the results obtained from the case study may be useful for robust and systematic effectiveness evaluation of safety measures in other cases worldwide. [ABSTRACT FROM AUTHOR]