1. First Reported Circulation of Equine Influenza H3N8 Florida Clade 1 Virus in Horses in Italy.
- Author
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Ricci, Ida, Tofani, Silvia, Lelli, Davide, Vincifori, Giacomo, Rosone, Francesca, Carvelli, Andrea, Diaconu, Elena Lavinia, La Rocca, Davide, Manna, Giuseppe, Sabatini, Samanta, Costantini, Donatella, Conti, Raffaella, Pacchiarotti, Giulia, and Scicluna, Maria Teresa
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EQUINE influenza ,VIRUS diseases ,INFLUENZA A virus ,HORSE breeding ,COMMUNICABLE diseases ,HORSES ,INFLUENZA viruses - Abstract
Simple Summary: Equine influenza (EI) is an acute and highly contagious viral disease of equids characterized by fever and respiratory signs. Ongoing antigenic mutations that are typical of influenza viruses, which may cause a reduction in the effectiveness of vaccines, highlight how crucial both surveillance and virus characterization are for updating vaccine compositions. The aim of this study was to verify the identity of the equine influenza virus strains detected in Italy, especially in the absence of formal active surveillance. Twenty nasal swabs, collected from symptomatic horses located in North and Central Italy between February and April 2019 were positive for influenza A virus (IAV) RRT-PCR. Sequencing identified an isolated strain as H3N8 Florida lineage clade 1 for one sample from Brescia, Lombardy Region. This study is the first report of H3N8 Florida lineage clade 1 circulation in Italy, confirming the value of monitoring for EIV circulating strain in relation to the appropriateness of the vaccine virus composition for maximum efficacy. Background: Equine influenza (EI) is a highly contagious viral disease of equids characterized by pyrexia and respiratory signs. Like other influenza A viruses, antigenic drift or shift could lead to a vaccine-induced immunity breakdown if vaccine strains are not updated. The aim of this study was to genetically characterize EIV strains circulating in Italy, detected in PCR-positive samples collected from suspected cases, especially in the absence of formal active surveillance. Methods: Between February and April 2019, blood samples and nasal swabs collected from each of the 20 symptomatic horses from North and Central Italy were submitted to the National Reference Centre for Equine Diseases in Italy to confirm preliminary analysis performed by other laboratories. Results: None of the sera analysed using haemagglutination inhibition and single radial haemolysis presented a predominant serological reactivity pattern for any antigen employed. All nasal swabs were positive with IAV RRT-PCR. Only one strain, isolated in an embryonated chicken egg from a sample collected from a horse of a stable located in Brescia, Lombardy, was identified as H3N8 Florida lineage clade 1 (FC1). In the constructed phylogenetic trees, this strain is located within the FC1, together with the virus isolated in France in 2018 (MK501761). Conclusions: This study reports the first detection of H3N8 FC1 in Italy, highlighting the importance of monitoring circulating EIV strains to verify the vaccine composition appropriateness for maximum efficacy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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