1. New Flavones, a 2-(2-Phenylethyl)-4H-chromen-4-one Derivative, and Anti-Inflammatory Constituents from the Stem Barks of Aquilaria sinensis
- Author
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Ping-Jyun Sung, Chih-Wen Shu, Jih Jung Chen, Mei-Ing Chung, Tsong-Long Hwang, Sin-Ling Wang, and Ming-Jen Cheng
- Subjects
Aquilaria sinensis ,medicine.drug_class ,Stereochemistry ,Neutrophils ,flavone ,2-(2-phenylethyl)-4H-chromen-4-one ,Anti-Inflammatory Agents ,Pharmaceutical Science ,Flavones ,Anti-inflammatory ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,chemistry.chemical_compound ,lcsh:Organic chemistry ,Drug Discovery ,medicine ,Humans ,Physical and Theoretical Chemistry ,anti-inflammatory activity ,Cytochalasin B ,chemistry.chemical_classification ,biology ,Molecular Structure ,Superoxide ,Plant Extracts ,Organic Chemistry ,Elastase ,structure elucidation ,biology.organism_classification ,Thymelaeaceae ,Tracheophyta ,chemistry ,Chemistry (miscellaneous) ,Chromone ,Plant Bark ,Molecular Medicine ,Leukocyte Elastase - Abstract
In the current study, two new flavones, 4′-O-geranyltricin (1) and 3′-O-geranylpolloin (2), and a new 2-(2-phenylethyl)-4H-chromen-4-one derivative, 7-hydroxyl-6-methoxy-2-(2-phenylethyl)chromone (3), have been isolated from the stem barks of A. sinensis, together with 21 known compounds 4–24. The structures of new compounds 1–3 were determined through spectroscopic and MS analyses. Compounds 2, 3, 5, 6, and 8–10 exhibited inhibition (IC50 ≤ 12.51 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3, 6, 8, 10, and 19 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 15.25 μM. This investigation reveals bioactive isolates (especially 2, 3, 5, 6, 8, 9, 10, and 19) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
- Published
- 2015