1. Austin-Type Meroterpenoids from Fungi Reported in the Last Five Decades: A Review.
- Author
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He, Jia-Li, Chen, Chang-Jing, Liu, Yong-Hong, Gao, Cheng-Hai, Wang, Rui-Ping, Zhang, Wen-Fei, and Bai, Meng
- Subjects
FUNGI classification ,FUNGI ,CYTOTOXINS ,CHEMICAL potential ,PENICILLIUM ,ASPERGILLUS - Abstract
Austin was first isolated as a novel polyisoprenoid mycotoxin from Aspergillus ustus in 1976. Subsequently, some new austin-type meroterpenoids (ATMTs) have been continually found. This review attempts to give a comprehensive summary of progress on the isolation, chemical structural features, biological activities, and fungal biodiversity of 104 novel ATMTs from 5 genera of terrestrial- and marine-derived fungi reported from October 1976 to January 2023. The genera of Penicillium and Aspergillus are the two dominant producers, producing 63.5% and 30.8% of ATMTs, respectively. Moreover, about 26.9% of ATMTs display various pronounced bioactivities, including insecticidal, anti-inflammatory, cytotoxicity, antibacterial, and PTP1B inhibitory activities. The chemical diversity and potential activities of these novel fungal ATMTs are reviewed for a better understanding, and a relevant summary focusing on the source fungi and their taxonomy is provided to shed light on the future development and research of austin-type meroterpenoids. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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