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Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B12 and folic acid may reduce depressive symptoms and improve health-related quality of life (HR-QoL) in older adults. This study aimed to test this hypothesis in a randomized controlled trial. Participants (N = 2919, ≥65 years, Hcy concentrations ≥12 µmol/L) received either 500 µg vitamin B12 and 400 µg folic acid daily or placebo for two years. Both tablets contained 15 µg vitamin D3. Depressive symptoms were measured with the Geriatric Depression Scale-15 (GDS-15). HR-QoL was assessed with the SF-12 Mental and Physical component summary scores and the EQ-5D Index score and Visual Analogue Scale. Differences in two-year change scores were analyzed with Analysis of Covariance (ANCOVA). Hcy concentrations decreased more in the intervention group, but two-year change scores of the GDS-15 and three of four HR-QoL measures did not differ between groups. The EQ-5D Index score declined less in the intervention group than in the placebo group (mean change 0.00 vs. -0.02, p = 0.004). In conclusion, two-year supplementation with vitamin B12 and folic acid in older adults with hyperhomocysteinemia showed that lowering Hcy concentrations does not reduce depressive symptoms, but it may have a small positive effect on HR-QoL. [ABSTRACT FROM AUTHOR]

Women prisoners are a population at a high risk of experiencing stress, anxiety, and other mental health problems. This is because stressors in prisons, such as strict prison rules, intimidation, and conflicts with other inmates and staff, cause a high prevalence of mental health problems in women prisoners. Mental health services, such as correctional-based interventions, are an important part of overcoming these problems. Therefore, this study aimed to identify correctional-based interventions for women prisoners with mental health problems, specifically to determine the types of correctional-based interventions, the types of mental health problems experienced by women prisoners, and the effectiveness of the interventions. The method used was a scoping review based on Arksey and O'Malley's framework. Articles were searched using Scopus, CINAHL, PubMed, Science Direct, and Google Scholar with the keywords "Mental Health Care" OR "Mental Health Services" AND "Correctional Program" AND "Interventions" AND "Mental Disorder" OR "Mental Health Problems" AND Women" OR "Female" AND "Inmates" OR "Offenders" OR "Prisoners" OR "Convicts". The inclusion criteria used were the year of publication (2000–2023), full-text articles in English, and the study sample was women prisoners with mental health problems. After selection, a total of 10 articles were found to meet the review inclusion criteria. The results showed that the correctional-based interventions given to women prisoners with mental health problems included Yoga, which combines mind and body; Seeking Safety, which was a manual CBT model; Transactional Analysis (TA) training program to enhance communication, relationships, and personal well-being; Transcendental Meditation (TM), a simple technique to reduce mental stress; Acceptance and Commitment Therapy (ACT) teaches the ability to accept painful or unwanted emotions; and Trauma Effect Regulation to reduce post-traumatic stress disorder (PTSD). All correctional-based interventions had significant results and can be used by health practitioners in prisons to address mental health problems experienced by women prisoners. [ABSTRACT FROM AUTHOR]