1. The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis
- Author
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Milos Stulic, Milica Stojkovic Lalosevic, Djordje Culafic, Natasa Dostanic, Milica Ćulafić, Tamara Alempijevic, Sandra Vezmar Kovačević, Radmila Obrenovic, and Goran Jankovic
- Subjects
Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Cirrhosis ,liver cirrhosis ,Cystatin C ,hepatic artery resistive index ,Chronic liver disease ,Severity of Illness Index ,Gastroenterology ,Article ,03 medical and health sciences ,Liver disease ,Hepatic Artery ,0302 clinical medicine ,Fibrosis ,Internal medicine ,medicine ,Humans ,Clinical significance ,biology ,business.industry ,Area under the curve ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,3. Good health ,Cross-Sectional Studies ,medicine.anatomical_structure ,Area Under Curve ,030220 oncology & carcinogenesis ,biology.protein ,Female ,Vascular Resistance ,030211 gastroenterology & hepatology ,business ,Artery - Abstract
Background: Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis. Methods: The cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons. Results: We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 ± 0.06) and there was the statistically significant difference compared to controls (0.66 ± 0.03) (p < 0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child–Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results. Conclusion: We confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis.
- Published
- 2018