1. Value of ascitic fibronectin and cholesterol concentration in the differentiation between malignancy-related and non-malignant ascites.
- Author
-
Archimandritis A, Kapsalas D, Douvara M, Tjivras M, Tsirantonaki M, and Fertakis A
- Subjects
- Ascitic Fluid blood, Ascitic Fluid diagnosis, Cholesterol blood, Diagnosis, Differential, Fibronectins blood, Humans, Neoplasms complications, Neoplasms diagnosis, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Ascitic Fluid etiology, Cholesterol analysis, Fibronectins analysis
- Abstract
In this prospective study, we tried to evaluate various "humoral tests of malignancy" regarding their efficiency of discriminating between malignancy-related and non-malignant ascites. Fibronectin, total protein, number of cells, LDH, pH, specific gravity and cytology were compared in the ascitic fluid of 51 patients with malignancy-related and 52 patients with non-malignant ascites; patients with tuberculous peritonitis were not included. Ascitic fluid cholesterol was determined in 36 of 51 malignancy-related and in 37 of 52 non-malignant ascites. Cytology and fibronectin were found 100% specific with diagnostic efficiency 87.5% and 94.2% respectively under optimal conditions. Cholesterol was neither sensitive nor specific. It is concluded that fibronectin was a valuable test for malignancy-associated ascites.
- Published
- 1996