1. [Rapid Idylla™ mutational testing: Current and future theranostic applications].
- Author
-
Bourhis A, Remoué A, Samaison L, and Uguen A
- Subjects
- DNA Mutational Analysis, High-Throughput Nucleotide Sequencing, Humans, Mutation, Precision Medicine, Proto-Oncogene Proteins B-raf genetics, Proto-Oncogene Proteins p21(ras) genetics, Carcinoma, Non-Small-Cell Lung diagnosis, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung genetics, Colorectal Neoplasms diagnosis, Colorectal Neoplasms drug therapy, Colorectal Neoplasms genetics, Lung Neoplasms diagnosis, Lung Neoplasms drug therapy, Lung Neoplasms genetics
- Abstract
Molecular analyses have become mandatory for treatment choices in patients with various advanced cancers. Beside next generation sequencing (NGS) analyzing genes panels, non-NGS targeted analyses about the main biomarkers remain of interest. In this article, we review the data about the fast and fully automated real-time PCR platform Idylla™ (Biocartis, Mechelen, Belgium) permitting the mutational analyses of BRAF, KRAS, NRAS, EGFR and microsatellite instability notably in melanoma, non-small-cell lung cancer and colorectal cancer samples. Future applications as well as the implementation of Idylla™ in the workflow of pathology and/or molecular biology laboratories are also discussed., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF