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2. [Anhidrotic activity of anticholinergics in mice. Influence of mode of administration].

Author

Marcy R, Quermonne MA, and Nguyen TM

Subjects
Administration, Topical, Animals, Atropine administration & dosage, Atropine pharmacology, Drug Evaluation, Preclinical, Hydroxyzine administration & dosage, Hydroxyzine pharmacology, Injections, Mice, Quaternary Ammonium Compounds administration & dosage, Quaternary Ammonium Compounds pharmacology, Scopolamine administration & dosage, Scopolamine pharmacology, Parasympatholytics pharmacology, Sweating drug effects
Abstract

Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relative anhidrotic activities according to the mode of administration of the different anticholinergics showed definite differences, e.g. hydroxyzine, which was the less active per i.p. route, was the most active per topical route. The method is likely to be a useful test for selecting the most active anticholinergic and its most efficient route of administration for the treatment of hyperhidrosis.

Published
1977

3. [Variation of the anhidrotic activities of anticholinergics with different routes of administration (author's transl)].

Author

Marcy R, Quermonne MA, and Nguyen TM

Subjects
Administration, Topical, Animals, Atropine administration & dosage, Atropine pharmacology, Hydroxyzine administration & dosage, Hydroxyzine pharmacology, Injections, Intraperitoneal, Mice, Quaternary Ammonium Compounds administration & dosage, Quaternary Ammonium Compounds pharmacology, Scopolamine administration & dosage, Scopolamine pharmacology, Hypohidrosis drug therapy, Parasympatholytics administration & dosage, Parasympatholytics pharmacology
Abstract

Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relative anhidrotic activities according to the mode of administration of the different anticholinergics showed definite differences, e.g. hydroxyzine, which was the less active per i.p. route, was the most active per topical route. The method is likely to be a useful test for selecting the most active anticholinergic and its most efficient route of administration for the treatment of hyperhidrosis.

Published
1977

10. [Influence of several drugs of the adrenergic sphere on rat paw inflammatory edema. I. Action of naphtazoline, ephedrine, metaraminol, bamethan, yohimbin and propranolol].

Author

Marçais H and Marcy R

Subjects
Animals, Ephedrine therapeutic use, Ethanolamines therapeutic use, Metaraminol therapeutic use, Naphthalenes therapeutic use, Propranolol therapeutic use, Rats, Secologanin Tryptamine Alkaloids therapeutic use, Anti-Inflammatory Agents, Edema prevention & control, Sympatholytics therapeutic use, Sympathomimetics therapeutic use, Vasoconstrictor Agents therapeutic use, Vasodilator Agents therapeutic use
Published
1970

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