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4 results on '"Skene, Allan M."'

1. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome

Author

Cannon, Christopher P., McCabe, Carolyn H., Muhlestein, Brent, Cairns, Richard, Braunwald, Eugene, Grayston J. Thomas, Giugliano, Robert P., and Skene, Allan M.

Subjects
Antibiotics -- Health aspects, Coronary heart disease -- Risk factors, Chlamydia -- Care and treatment
Abstract

The antibiotic treatment of Chlamydia pneumoniae found within atherosclerotic plaques, and elevated titers of antibody to this organism linked to a higher risk of coronary events is studied. It is concluded that despite long-term treatment with a bactericidal antibiotic effective against Chlamydia pneumoniae, no reduction in the rate of cardiovascular events was observed.

Published
2005

2. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation

Author

Sabatine, Marc S., Gibson, C. Michael, Montalescot, Gilles, Claeys, Marc J., Skene, Allan M., Braunwald, Eugene, McCabe, Carolyn H., Hill, Karen A., Cools, Frank, Theroux, Pierre, and Lopez-Sendon, Jose L.

Subjects
Plavix (Medication) -- Usage, Thrombolytic drugs -- Usage, Heart attack -- Drug therapy
Abstract

A study is conducted enrolling 3491 patients in the age group of 18 to 75 years of age, who presented within 12 hours after the onset of an ST-elevation myocardial infarction and randomly assigned them to receive clopidogrel or placebo. In patients 75 years or younger who have myocardial infraction with ST-segment elevation, the addition of clopidogrel improves the patency rate of the infarct-related artery and reduces ischemic complications.

Published
2005

3. Intensive versus moderate lipid lowering with statins after acute coronary syndromes

Author

Cannon, Christopher P., Braunwald, Eugene, McCabe, Carolyn H., Rader, Daniel J., Pfeffer, Marc A., Skene, Allan M., Rouleau, Jean L., Belder, Rene, Joyal, Steven V., and Hill, Karen A.

Subjects
Cardiovascular diseases -- Risk factors, Cardiovascular diseases -- Drug therapy, Antilipemic agents -- Evaluation, Statins -- Evaluation
Abstract

The risk of Cardiovascular events may be reduced by Lipid-lowering therapy with statins. An intensive lipid-lowering statin regimen provides greater protection against death or major cardiovascular events for patients who have had an acute coronary syndrome.

Published
2004

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