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Your search keyword '"Geyer, Charles E."' showing total 14 results
Start Over Author "Geyer, Charles E." Publisher massachusetts medical society
14 results on '"Geyer, Charles E."'

1. Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer

Author

Tutt, Andrew N.J., primary, Garber, Judy E., additional, Kaufman, Bella, additional, Viale, Giuseppe, additional, Fumagalli, Debora, additional, Rastogi, Priya, additional, Gelber, Richard D., additional, de Azambuja, Evandro, additional, Fielding, Anitra, additional, Balmaña, Judith, additional, Domchek, Susan M., additional, Gelmon, Karen A., additional, Hollingsworth, Simon J., additional, Korde, Larissa A., additional, Linderholm, Barbro, additional, Bandos, Hanna, additional, Senkus, Elżbieta, additional, Suga, Jennifer M., additional, Shao, Zhimin, additional, Pippas, Andrew W., additional, Nowecki, Zbigniew, additional, Huzarski, Tomasz, additional, Ganz, Patricia A., additional, Lucas, Peter C., additional, Baker, Nigel, additional, Loibl, Sibylle, additional, McConnell, Robin, additional, Piccart, Martine, additional, Schmutzler, Rita, additional, Steger, Guenther G., additional, Costantino, Joseph P., additional, Arahmani, Amal, additional, Wolmark, Norman, additional, McFadden, Eleanor, additional, Karantza, Vassiliki, additional, Lakhani, Sunil R., additional, Yothers, Greg, additional, Campbell, Christine, additional, and Geyer, Charles E., additional

Published
2021
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2. Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer

Author

Tutt, Andrew N J, Garber, Judy E, Kaufman, Bella, Viale, Giuseppe, Fumagalli, Debora, Rastogi, Priya, Gelber, Richard D, de Azambuja, Evandro, Fielding, Anitra, Balmaña, Judith, Domchek, Susan M, Gelmon, Karen A, Hollingsworth, Simon J, Korde, Larissa A, Linderholm, Barbro, Bandos, Hanna, Senkus, Elżbieta, Suga, Jennifer M, Shao, Zhimin, Pippas, Andrew W, Nowecki, Zbigniew, Huzarski, Tomasz, Ganz, Patricia A, Lucas, Peter C, Baker, Nigel, Loibl, Sibylle, McConnell, Robin, Piccart, Martine, Schmutzler, Rita, Steger, Guenther G, Costantino, Joseph P, Arahmani, Amal, Wolmark, Norman, McFadden, Eleanor, Karantza, Vassiliki, Lakhani, Sunil R, Yothers, Greg, Campbell, Christine, and Geyer, Charles E

Subjects
610 Medicine & health
Abstract

BACKGROUND Poly(adenosine diphosphate-ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients with BRCA1 or BRCA2 germline mutation-associated early breast cancer. METHODS We conducted a phase 3, double-blind, randomized trial involving patients with human epidermal growth factor receptor 2 (HER2)-negative early breast cancer with BRCA1 or BRCA2 germline pathogenic or likely pathogenic variants and high-risk clinicopathological factors who had received local treatment and neoadjuvant or adjuvant chemotherapy. Patients were randomly assigned (in a 1:1 ratio) to 1 year of oral olaparib or placebo. The primary end point was invasive disease-free survival. RESULTS A total of 1836 patients underwent randomization. At a prespecified event-driven interim analysis with a median follow-up of 2.5 years, the 3-year invasive disease-free survival was 85.9% in the olaparib group and 77.1% in the placebo group (difference, 8.8 percentage points; 95% confidence interval [CI], 4.5 to 13.0; hazard ratio for invasive disease or death, 0.58; 99.5% CI, 0.41 to 0.82; P

Published
2021
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3. Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer

Author

Swain, Sandra M., Jong-Hyeon, Jeong, Geyer, Charles E. Jr, Costantino, Joseph P., Pajon, Eduardo R., Fehrenbacher, Louis, Atkins, James N., Polikoff, Jonathan, Vogel, Victor G., Erban, John K., Rastogi, Priya, Livingston, Robert P., Perez, Edith A., Mamounas, Eleftherios, P., Land, Stephanie R., Ganz, Patricia A., and Wolmark, Norman

Subjects
Docetaxel -- Comparative analysis, Docetaxel -- Health aspects, Breast cancer -- Drug therapy, Doxorubicin -- Comparative analysis, Doxorubicin -- Health aspects, Chemotherapy -- Evaluation, Amenorrhea -- Causes of, Cancer -- Chemotherapy, Cancer -- Evaluation
Abstract

A study was conducted to evaluate and compare the efficacy of concurrent docetaxel (ACT) versus sequential regimens of ACT on survival rate in early breast cancer. Results indicated that sequential ACT far greatly improved disease free survival as well as overall survival rate in the case of such patients.

Published
2010

4. Lapatinib plus capecitabine for HER2-positive advanced breast cancer

Author

Geyer, Charles E., Forster, John, Lindquist, Deborah, Chan, Stephen, Romieu, C. Gilles, Pienkowski, Tadeusz, Jagiello-Gruszfeld, Agnieszka, Crown, John, Chan, Arlene, Kaufman, Bella, Skarlos, Dimosthenis, Campone, Mario, Davidson, Neville, and Berger, Mark

Subjects
Lapatinib (Medication) -- Dosage and administration, Breast cancer -- Drug therapy
Abstract

A phase 3, randomized, open-label study compared lapatinib plus capecitabine with capecitabine alone in women with progressive, human epidermal growth factor receptor type 2-positive (HER2-positive), locally advanced or metastatic breast cancer who were previously treated with a minimum of an anthracycline, a taxane, and trastuzumab. Results provide support for the use of lapatinib and capecitabine in women with progression of HER2-positive breast cancer after treatment with trastuzumab.

Published
2006

5. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

Author

Romond, Edward H., Davidson, Nancy E., Swain, Sandra M., Visscher, Daniel W., Mamounas, Eleftherios P., Perez, Edith A., Bryant, John, Suman, Vera J., Geyer, Charles E., Jr., Martino, Silvana, Paik, Soonmyung, Kaufman, Peter A., Elizabeth Tan-Chiu, Fehrenbacher, Louis, Kutteh, Leila A., Vogel, Victor G., Pisansky, Thomas M., Yothers, Greg, Jenkins, Robert B., Brown, Ann M., Dakhil, Shaker R., Lingle, Wilma L., Klein, Pamela M., Ingle, James N., and Wolmark, Norman

Subjects
Breast cancer -- Drug therapy, Women -- Health aspects
Abstract

The combined results of two trials, which compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed herceptin (HER2)-positive breast cancer, are presented. Trastuzumab combined with paclitaxel after doxorubicin and cyclophosphamide improves outcomes among women with surgically removed HER2-positive breast cancer.

Published
2005

6. Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer

Author

Sparano, Joseph A., primary, Gray, Robert J., additional, Ravdin, Peter M., additional, Makower, Della F., additional, Pritchard, Kathleen I., additional, Albain, Kathy S., additional, Hayes, Daniel F., additional, Geyer, Charles E., additional, Dees, Elizabeth C., additional, Goetz, Matthew P., additional, Olson, John A., additional, Lively, Tracy, additional, Badve, Sunil S., additional, Saphner, Thomas J., additional, Wagner, Lynne I., additional, Whelan, Timothy J., additional, Ellis, Matthew J., additional, Paik, Soonmyung, additional, Wood, William C., additional, Keane, Maccon M., additional, Gomez Moreno, Henry L., additional, Reddy, Pavan S., additional, Goggins, Timothy F., additional, Mayer, Ingrid A., additional, Brufsky, Adam M., additional, Toppmeyer, Deborah L., additional, Kaklamani, Virginia G., additional, Berenberg, Jeffrey L., additional, Abrams, Jeffrey, additional, and Sledge, George W., additional

Published
2019
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7. Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer

Author

von Minckwitz, Gunter, primary, Huang, Chiun-Sheng, additional, Mano, Max S., additional, Loibl, Sibylle, additional, Mamounas, Eleftherios P., additional, Untch, Michael, additional, Wolmark, Norman, additional, Rastogi, Priya, additional, Schneeweiss, Andreas, additional, Redondo, Andres, additional, Fischer, Hans H., additional, Jacot, William, additional, Conlin, Alison K., additional, Arce-Salinas, Claudia, additional, Wapnir, Irene L., additional, Jackisch, Christian, additional, DiGiovanna, Michael P., additional, Fasching, Peter A., additional, Crown, John P., additional, Wülfing, Pia, additional, Shao, Zhimin, additional, Rota Caremoli, Elena, additional, Wu, Haiyan, additional, Lam, Lisa H., additional, Tesarowski, David, additional, Smitt, Melanie, additional, Douthwaite, Hannah, additional, Singel, Stina M., additional, and Geyer, Charles E., additional

Published
2019
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8. Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer

Author

Francis, Prudence A., primary, Pagani, Olivia, additional, Fleming, Gini F., additional, Walley, Barbara A., additional, Colleoni, Marco, additional, Láng, István, additional, Gómez, Henry L., additional, Tondini, Carlo, additional, Ciruelos, Eva, additional, Burstein, Harold J., additional, Bonnefoi, Hervé R., additional, Bellet, Meritxell, additional, Martino, Silvana, additional, Geyer, Charles E., additional, Goetz, Matthew P., additional, Stearns, Vered, additional, Pinotti, Graziella, additional, Puglisi, Fabio, additional, Spazzapan, Simon, additional, Climent, Miguel A., additional, Pavesi, Lorenzo, additional, Ruhstaller, Thomas, additional, Davidson, Nancy E., additional, Coleman, Robert, additional, Debled, Marc, additional, Buchholz, Stefan, additional, Ingle, James N., additional, Winer, Eric P., additional, Maibach, Rudolf, additional, Rabaglio-Poretti, Manuela, additional, Ruepp, Barbara, additional, Di Leo, Angelo, additional, Coates, Alan S., additional, Gelber, Richard D., additional, Goldhirsch, Aron, additional, and Regan, Meredith M., additional

Published
2018
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9. Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

Author

Sparano, Joseph A., primary, Gray, Robert J., additional, Makower, Della F., additional, Pritchard, Kathleen I., additional, Albain, Kathy S., additional, Hayes, Daniel F., additional, Geyer, Charles E., additional, Dees, Elizabeth C., additional, Goetz, Matthew P., additional, Olson, John A., additional, Lively, Tracy, additional, Badve, Sunil S., additional, Saphner, Thomas J., additional, Wagner, Lynne I., additional, Whelan, Timothy J., additional, Ellis, Matthew J., additional, Paik, Soonmyung, additional, Wood, William C., additional, Ravdin, Peter M., additional, Keane, Maccon M., additional, Gomez Moreno, Henry L., additional, Reddy, Pavan S., additional, Goggins, Timothy F., additional, Mayer, Ingrid A., additional, Brufsky, Adam M., additional, Toppmeyer, Deborah L., additional, Kaklamani, Virginia G., additional, Berenberg, Jeffrey L., additional, Abrams, Jeffrey, additional, and Sledge, George W., additional

Published
2018
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10. Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

Author

Sparano, Joseph A., primary, Gray, Robert J., additional, Makower, Della F., additional, Pritchard, Kathleen I., additional, Albain, Kathy S., additional, Hayes, Daniel F., additional, Geyer, Charles E., additional, Dees, Elizabeth C., additional, Perez, Edith A., additional, Olson, John A., additional, Zujewski, JoAnne, additional, Lively, Tracy, additional, Badve, Sunil S., additional, Saphner, Thomas J., additional, Wagner, Lynne I., additional, Whelan, Timothy J., additional, Ellis, Matthew J., additional, Paik, Soonmyung, additional, Wood, William C., additional, Ravdin, Peter, additional, Keane, Maccon M., additional, Gomez Moreno, Henry L., additional, Reddy, Pavan S., additional, Goggins, Timothy F., additional, Mayer, Ingrid A., additional, Brufsky, Adam M., additional, Toppmeyer, Deborah L., additional, Kaklamani, Virginia G., additional, Atkins, James N., additional, Berenberg, Jeffrey L., additional, and Sledge, George W., additional

Published
2015
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11. Adjuvant Ovarian Suppression in Premenopausal Breast Cancer

Author

Francis, Prudence A., primary, Regan, Meredith M., additional, Fleming, Gini F., additional, Láng, István, additional, Ciruelos, Eva, additional, Bellet, Meritxell, additional, Bonnefoi, Hervé R., additional, Climent, Miguel A., additional, Da Prada, Gian Antonio, additional, Burstein, Harold J., additional, Martino, Silvana, additional, Davidson, Nancy E., additional, Geyer, Charles E., additional, Walley, Barbara A., additional, Coleman, Robert, additional, Kerbrat, Pierre, additional, Buchholz, Stefan, additional, Ingle, James N., additional, Winer, Eric P., additional, Rabaglio-Poretti, Manuela, additional, Maibach, Rudolf, additional, Ruepp, Barbara, additional, Giobbie-Hurder, Anita, additional, Price, Karen N., additional, Colleoni, Marco, additional, Viale, Giuseppe, additional, Coates, Alan S., additional, Goldhirsch, Aron, additional, and Gelber, Richard D., additional

Published
2015
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12. Adjuvant Exemestane with Ovarian Suppression in Premenopausal Breast Cancer

Author

Pagani, Olivia, primary, Regan, Meredith M., additional, Walley, Barbara A., additional, Fleming, Gini F., additional, Colleoni, Marco, additional, Láng, István, additional, Gomez, Henry L., additional, Tondini, Carlo, additional, Burstein, Harold J., additional, Perez, Edith A., additional, Ciruelos, Eva, additional, Stearns, Vered, additional, Bonnefoi, Hervé R., additional, Martino, Silvana, additional, Geyer, Charles E., additional, Pinotti, Graziella, additional, Puglisi, Fabio, additional, Crivellari, Diana, additional, Ruhstaller, Thomas, additional, Winer, Eric P., additional, Rabaglio-Poretti, Manuela, additional, Maibach, Rudolf, additional, Ruepp, Barbara, additional, Giobbie-Hurder, Anita, additional, Price, Karen N., additional, Bernhard, Jürg, additional, Luo, Weixiu, additional, Ribi, Karin, additional, Viale, Giuseppe, additional, Coates, Alan S., additional, Gelber, Richard D., additional, Goldhirsch, Aron, additional, and Francis, Prudence A., additional

Published
2014
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13. Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer

Author

Bear, Harry D., primary, Tang, Gong, additional, Rastogi, Priya, additional, Geyer, Charles E., additional, Robidoux, André, additional, Atkins, James N., additional, Baez-Diaz, Luis, additional, Brufsky, Adam M., additional, Mehta, Rita S., additional, Fehrenbacher, Louis, additional, Young, James A., additional, Senecal, Francis M., additional, Gaur, Rakesh, additional, Margolese, Richard G., additional, Adams, Paul T., additional, Gross, Howard M., additional, Costantino, Joseph P., additional, Swain, Sandra M., additional, Mamounas, Eleftherios P., additional, and Wolmark, Norman, additional

Published
2012
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