1. DNA-Encoded Glutamine Synthetase Enzyme as Ammonia-Lowering Therapeutic for Hyperammonemia
- Author
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Karuppiah Muthumani, Laurent Humeau, Xizhou Zhu, David B. Weiner, Makan Khoshnejad, Rehman Qureshi, Ami Patel, Yaya Dia, Ziyang Xu, Kun Yun, and Krzysztof Wojtak
- Subjects
Glutamine ,Brain damage ,Gene delivery ,Biochemistry ,Mice ,Ammonia ,chemistry.chemical_compound ,Glutamate-Ammonia Ligase ,Glutamine synthetase ,Drug Discovery ,Genetics ,medicine ,Animals ,Humans ,Hyperammonemia ,Molecular Biology ,chemistry.chemical_classification ,Electroporation ,food and beverages ,DNA ,medicine.disease ,Disease Models, Animal ,Enzyme ,Liver ,chemistry ,Molecular Medicine ,medicine.symptom - Abstract
Hyperammonemia is a dangerous life-threatening metabolic complication characterized by markedly elevated ammonia levels that can lead to irreversible brain damage if not carefully monitored. Current pharmacological treatment strategies available for hyperammonemia patients are suboptimal and associated with major side effects. In this study, we focus on developing and evaluating the
- Published
- 2020