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1. Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mouse Model of Alport Syndrome

Author

Lucy Phillips, Shiguang Liu, Fang Wang, Li Yang, Oxana Ibraghimov-Beskrovnaya, Deidre Mackenna, Jifan Guo, Suxia Wang, Wenping Song, Jie Ding, Ekkehard Leberer, Cynthia Pryce, Ethan Y Xu, Qun He, Yanqin Zhang, and Joseph Boulanger

Subjects
Collagen Type IV, Male, Adolescent, Biopsy, Nephritis, Hereditary, Disease, Kidney, Autoantigens, Severity of Illness Index, Mice, Type IV collagen, microRNA, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Alport syndrome, Child, Molecular Biology, Gene, Genetic Association Studies, Mice, Knockout, business.industry, Gene Expression Profiling, medicine.disease, Fibrosis, Disease Models, Animal, MicroRNAs, Gene Expression Regulation, Cancer research, Molecular Medicine, Female, business, Biomarkers, Kidney disease
Abstract

Alport syndrome is a genetic disease caused by mutations in type IV collagen and is characterized by progressive kidney disease. The Col4α3−/− mouse model recapitulates the main features of human A...

Published
2019
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