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Start Over Author "Bubo Zhou" Publisher mary ann liebert inc
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2. Detecting Single Nucleotide Polymorphisms in MEF2B and UCP3 and Elucidating Their Association with Sheep Growth Traits

Author

Wenxin Li, Jiangbo Cheng, Xiaobin Yang, Xiaolong Li, Yukun Zhang, Bubo Zhou, Weimin Wang, Lvfeng Yuan, Changchun Lin, Xiaoxue Zhang, Jianghui Wang, Liming Zhao, Qizhi Song, Deyin Zhang, Yuan Zhao, Fadi Li, and Dan Xu

Subjects
Silent mutation, medicine.medical_specialty, Single-nucleotide polymorphism, Cell Biology, General Medicine, Biology, Body weight, DNA sequencing, Endocrinology, Internal medicine, Genotype, Correlation analysis, Genetics, medicine, Synonymous substitution, Molecular Biology, UCP3
Abstract

Herein we detected single nucleotide polymorphisms in MEF2B and UCP3 by DNA sequencing and the KASPar technology and analyzed their association with sheep growth traits. Two synonymous mutations, g.1826 C > T and g.10266 G > C, were detected, respectively, and they were found to be significantly associated with sheep growth traits (p T, the average body weight and chest and cannon circumference of sheep with the CC genotype were significantly higher than those of sheep with the CT and TT genotypes (p C, the average body weight and chest and cannon circumference of sheep with the GG genotype were significantly higher than those of sheep with the GC and CC genotypes (p < 0.05). Moreover, the average body weight of sheep with the CC/GG genotype was higher compared with those of other genotype combinations. We also assessed MEF2B and UCP3 expression in different sheep tissues, confirming their expression in all examined tissues. To summarize, we believe that the polymorphisms identified in MEF2B and UCP3 can serve as molecular markers for sheep growth traits.

Published
2021

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