1. Short Communication: Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders
- Author
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Ratto-Kim, Silvia, Schuetz, Alexandra, Sithinamsuwan, Pasiri, Barber, John, Hutchings, Nicholas, Lerdlum, Sukalaya, Fletcher, James L. K., Phuang-Ngern, Yuwadee, Chuenarom, Weerawan, Tipsuk, Somporn, Pothisri, Mantana, Jadwattanakul, Tanate, Jirajariyavej, Supunnee, Sajjaweerawan, Chayada, Akapirat, Siriwat, Chalermchai, Thep, Suttichom, Duanghathai, Kaewboon, Boot, Prueksakaew, Peeriya, Karnsomlap, Putthachard, Clifford, David, Paul, Robert H., de Souza, Mark S., Kim, Jerome H., Ananworanich, Jintanat, and Valcour, Victor
- Subjects
Adult ,Male ,Immunity, Cellular ,AIDS Dementia Complex ,Immunology ,HIV Infections ,CD8-Positive T-Lymphocytes ,Middle Aged ,Viral Load ,Lymphocyte Activation ,Thailand ,Plasma ,Young Adult ,Humans ,Female - Abstract
HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8(+) T cell activation (HLA-DR(+)/CD38(+)) and HIV-specific CD8(+) T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8(+) T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b(+)) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8(+) T cells in the mechanism of HAND development.
- Published
- 2018