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AbstractThe effect of a mangosteen product containing multivitamins and essential minerals was tested on immune function and well-being in healthy adults. A randomized, double blinded, placebo-controlled study was conducted in 59 healthy human subjects (40–60 years old). Changes from baseline immune function were measured after a 30-day consumption of the mangosteen product and the placebo. The subjects' self-appraisal of their health status was also surveyed. A xanthone-rich mangosteen product intake increased mean values for peripheral T-helper cell frequency (P= .020) and reduced the serum C-reactive protein concentration (P= .014). Increases in peripheral CD4/CD8 double-positive (DP) T-cell frequency and serum complement C3, C4, and interleukin (IL)-1αconcentrations were significantly higher in the experimental group than in the placebo group (DP, P= .038; C3, P= .017; C4, P= .031; IL-1α, P= .006). At the end of study, serum IL-1αand IL-1βconcentrations in the study group were significantly higher than that in the placebo group (IL-1α, P= .033; IL-1β, P= .04). Furthermore, more participants in the experimental group reported greatly improved overall health status compared with participants receiving placebo (P= .001). The results indicated that the intake of an antioxidant-rich product significantly enhanced immune responses and improved the subject's self-appraisal on his or her overall health status. [ABSTRACT FROM AUTHOR]