1. Young Persimmon Fruit Extract Suppresses Obesity by Modulating Lipid Metabolism in White Adipose Tissue of Obese Mice.
- Author
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Kim MY, Shin MR, Seo BI, Noh JS, and Roh SS
- Subjects
- Adipogenesis drug effects, Adipose Tissue, White metabolism, Animals, Cholesterol blood, Fruit chemistry, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Obesity blood, Obesity physiopathology, Adipose Tissue, White drug effects, Anti-Obesity Agents administration & dosage, Diospyros chemistry, Lipid Metabolism drug effects, Obesity drug therapy
- Abstract
Young persimmon fruit (YPF) has recently been reported to have a regulatory effect on lipid metabolism. The aim of this study was to investigate whether the YPF aqueous extract (YPFE) exert an antiobesity effect by modulating lipid metabolism in the white adipose tissue (WAT) of obese C57BLKS/J db/db mice. YPFE (100 or 200 mg/kg body weight/day) or distilled water as a vehicle was orally administered by gavage to 12-week-old obese male db/db mice for 3 weeks ( n = 7 for each group). YPFE administration significantly reduced body weight and WAT size. Furthermore, YPFE considerably reduced triglyceride and cholesterol concentrations in serum and WAT. Obese vehicle treated mice exhibited an enhanced protein expression of adipogenic and lipogenic genes. However, this increased expression was alleviated in the YPFE-fed groups, resulting in inhibition of adipogenesis and downregulation of fatty acid synthesis. In addition, there was an increase in the level of transcription factors associated with fatty acid oxidation in the YPFE-treated group. In obese mice, the expression of proteins associated with cholesterol metabolism was augmented. YPFE did not affect cholesterol synthesis, but cholesterol efflux-related proteins were significantly upregulated. YPF exerts beneficial effects on obesity by inhibiting adipogenesis and reducing lipid synthesis and accumulation by regulation of lipid-related transcription factors in the WAT of obese mice.
- Published
- 2020
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