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1. Measurement of intima-media thickness of common carotid arteries using ultrasound in patients with familial and non-familial hypercholesterolaemia and correlation of intima-media thickness to obesity.

Author

Nafikudin M, Nawawi H, Muid S, Annuar R, Yusoff K, and Khalid BA

Subjects
Adult, Female, Humans, Hypercholesterolemia complications, Hyperlipoproteinemia Type II complications, Male, Middle Aged, Obesity etiology, Ultrasonography, Carotid Artery, Common ultrastructure, Hypercholesterolemia diagnostic imaging, Hyperlipoproteinemia Type II diagnostic imaging, Obesity diagnostic imaging, Tunica Intima diagnostic imaging, Tunica Media diagnostic imaging
Abstract

Ultrasonographic measurements of the intima-media thickness (IMT) of common carotid arteries (CCA) were taken in 50 patients with familial hypercholesterolaemia (FH) and 57 patients with non-familial hypercholesterolemia (NFH). The lipid profile, body mass index (BMI) and waist-hip ratio (WHR) of each patient were recorded. In FH patients, the IMT was significantly higher in overweight and elevated WHR subgroups compared to the normal with significant correlations between BMI and WHR to the IMT. In NFH patients, the IMT was significantly higher in the elevated WHR compared to the normal subgroup but the correlations between either BMI or WHR to IMT were insignificant. These suggest that the environmentally modified anthropometric indices may have an effect on atherosclerosis in genetically determined hypercholesterolaemia in FH patients.

Published
2003

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