1. Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi
- Author
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Ilkay Erdogan Orhan, Bilge Sener, Marcel Kaiser, Reto Brun, and Deniz Tasdemir
- Subjects
Lycopodium clavatum ,Antioxidant ,medicine.drug_class ,medicine.medical_treatment ,Clinical Biochemistry ,Flavonoid ,in-vitro ,alkaloids ,01 natural sciences ,Biochemistry ,drugs ,Nephrotoxicity ,chemistry.chemical_compound ,Oral administration ,parasitic diseases ,medicine ,Phenols ,lycopodiaceae ,leishmaniasis ,Molecular Biology ,chemistry.chemical_classification ,biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,antiprotozoal activity ,huperzine-a ,Biochemistry (medical) ,natural-products ,gambiense ,Propolis ,biology.organism_classification ,rhodesiense ,0104 chemical sciences ,3. Good health ,inhibitor ,010404 medicinal & biomolecular chemistry ,human african trypanosomiasis ,Antiprotozoal ,cytotoxicity ,lycopodium - Abstract
Objective: the aim of this study is to investigate the in vitro antioxidant activity, the total phenol and flavonoid content and the possible protective effects of commercial propolis on gentamicin-induced nephrotoxicity in rabbits. Methods: the in vitro antioxidant activity was measured by ferric reducing antioxidant power assay and cupric reducing antioxidant capacity assay, the total phenols content was measured by folin–ciocalteau assay, the flavonoids content by the alcl3 colorimetric method and the renoprotective effects of propolis methanol extract was evaluated in a rabbit model of gentamicin-induced nephrotoxicity. The protective effects of propolis on gentamicin-induced nephrotoxicity in rabbits were evaluated through biochemical parameter (measuring serum urea and creatinine) and histopathological alterations in kidneys Results: methanol extract of propolis showed a strong antioxidant activity, which is attributed to its high phenolic and flavonoid contents. Oral administration of propolis extract to rabbits at a dose of 1 mg/kg body weight significantly protected against histopathological and biochemical alterations induced by gentamicin. Conclusion: the present study demonstrated that commercial propolis is strong antioxidant and is effective for the prevention of gentamicin-induced renal damage in rabbits
- Published
- 2013
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