1. Diurnal Measurements of Macular Thickness and Vessel Density on OCT Angiography in Healthy Eyes and Those with Ocular Hypertension and Glaucoma
- Author
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Lara Enrica Urbini, Paolo Milani, Fulvio Bergamini, Lorenza Scotti, Ennio Bulone, Antonella Zambon, Stefania Callegarin, Sara Bochicchio, Luca Pisano, Milani, P, Bochicchio, S, Urbini, L, Bulone, E, Callegarin, S, Pisano, L, Scotti, L, Zambon, A, and Bergamini, F
- Subjects
Adult ,Male ,Intraocular pressure ,medicine.medical_specialty ,Corneal Pachymetry ,genetic structures ,Gonioscopy ,Glaucoma ,Ocular hypertension ,ocular hypertension, macular superficial capillary plexus and thickness ,Tonometry, Ocular ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,Macula Lutea ,Fluorescein Angiography ,Corneal pachymetry ,Intraocular Pressure ,Aged ,Morning ,medicine.diagnostic_test ,business.industry ,Retinal Vessels ,Retinal ,Middle Aged ,medicine.disease ,Fluorescein angiography ,Healthy Volunteers ,eye diseases ,Circadian Rhythm ,chemistry ,030221 ophthalmology & optometry ,Female ,Ocular Hypertension ,sense organs ,business ,Glaucoma, Open-Angle ,Tomography, Optical Coherence ,030217 neurology & neurosurgery - Abstract
Precis:Macular superficial capillary plexus (SCP) and thickness are reduced in eyes with glaucoma and ocular hypertension, but do not change significantly during the day. No relationships with age, intraocular pressure, systemic hypertension, or axial length were found.Purpose:The purpose of this study was to evaluate diurnal differences in retinal thickness and vessel density (VD) of the macular SCP and deep capillary plexus (DCP) using optical coherence tomography angiography among 3 groups: eyes with glaucoma, eyes with ocular hypertension, and healthy eyes.Methods:A consecutive series of individuals was recruited prospectively. Optical coherence tomography angiography was performed in the morning and in the evening.Results:Forty eyes from 23 individuals with glaucoma (58.35±6 y), 52 eyes from 32 individuals with ocular hypertension (58.84±7 y), and 73 eyes from 44 controls (57.84±6 y) were enrolled. Morning and evening measurements of all SCP-VD and retinal thickness parameters were statistically significantly different (P0.19). A positive linear correlation in diurnal changes was found between SCP-VD and DCP-VD in the fovea and in the parafovea (r=0.5567 and 0.5892, respectively) and between SCP-VD and retinal thickness in the fovea and in the parafovea (r=-0.2288 and 0.2418, respectively).Conclusions:Macular SCP-VD and thickness are reduced in eyes with glaucoma and ocular hypertension. Although diurnal changes in SCP-VD, DCP-VD and macular thickness were not significant among the groups, some linear correlations in increasing or decreasing values of the investigated parameters were found.
- Published
- 2020