1. Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke
- Author
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Alejandro Bustamante, Ana Rodríguez-Campello, Mikel Vicente, Antia Moreira, Meritxell Gomis, Mercè Salvat, Joan Martí-Fàbregas, Luis Mena, Ana Núñez-Guillén, Luis Prats-Sánchez, Josep Zaragoza, María Del Carmen García-Carreira, Marta Rubiera, Pol Camps-Renom, Angel Ois, Saima Bashir Viturro, Francisco Purroy, Manuel Gómez-Choco, Marta Olivé, Patricia Esteve, Xavier Ustrell, Marta Almeria, Laura Llull, Cecile van Eendenburg, Oriol Barrachina, Raquel Delgado-Mederos, Natalia Pérez de la Ossa, Pere Cardona, Dolores Cocho, Javier Codas, Esther Catena, Marina Guasch-Jiménez, Laia Seró, Manuel Requena, Joaquín Serena, E. Palomeras, Alejandro Martínez-Domeño, Gislaine Castilho de Oliveira, Daniel Guisado-Alonso, Sergio Amaro, and Jerzky Krupinski
- Subjects
Male ,Original Contributions ,Stroke severity ,coronavirus ,medicine.disease_cause ,Severity of Illness Index ,Thrombolytic Therapy ,Prospective Studies ,Stroke ,Thrombectomy ,Coronavirus ,Aged, 80 and over ,Age Factors ,Middle Aged ,Prognosis ,stroke ,cerebrovascular disease ,reperfusion ,thrombectomy ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,pandemics ,Clinical and Population Sciences ,Internal medicine ,medicine ,Humans ,In patient ,Mortality ,Aged ,Ischemic Stroke ,Advanced and Specialized Nursing ,SARS-CoV-2 ,business.industry ,Anticoagulants ,COVID-19 ,medicine.disease ,Functional Status ,Logistic Models ,Case-Control Studies ,Multivariate Analysis ,Ischemic stroke ,Neurology (clinical) ,prognosis ,business - Abstract
Supplemental Digital Content is available in the text., Background and Purpose: We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection. Methods: A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, National Institutes of Health Stroke Scale score, rate of reperfusion therapies, logistics, and metrics. Primary end point was functional outcome at 3 months. Favourable outcome was defined depending on the previous mRS score. Secondary outcome was mortality at 3 months. We performed mRS shift and multivariable analyses. Results: We evaluated 701 patients (mean age 72.3±13.3 years, 60.5% men) and 91 (13%) had COVID-19 infection. Median baseline National Institutes of Health Stroke Scale score was higher in patients with COVID-19 compared with patients without COVID-19 (8 [3–18] versus 6 [2–14], P=0.049). Proportion of patients with a favourable functional outcome was 33.7% in the COVID-19 and 47% in the non-COVID-19 group. However, after a multivariable logistic regression analysis, COVID-19 infection did not increase the probability of unfavourable functional outcome. Mortality rate was 39.3% among patients with COVID-19 and 16.1% in the non-COVID-19 group. In the multivariable logistic regression analysis, COVID-19 infection was a risk factor for mortality (hazard ratio, 3.14 [95% CI, 2.10–4.71]; P
- Published
- 2021