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170 results on '"Young V"'

1. Collagenase Clostridium Histolyticum-aaes for the Treatment of Cellulite in Women: Results From Two Phase 3 Randomized, Placebo-Controlled Trials.

Author

Kaufman-Janette, Joely, Joseph, John H., Kaminer, Michael S., Clark, James, Fabi, Sabrina G., Gold, Michael H., Goldman, Mitchel P., Katz, Bruce E., Peddy, Kappa, Schlessinger, Joel, Leroy Young, V., Davis, Matthew, Hurley, David, Liu, Genzhou, McLane, Michael P., Vijayan, Saji, and Bass, Lawrence S.

Published
2021
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4. Neuroligin 2 regulates spinal GABAergic plasticity in hyperalgesic priming, a model of the transition from acute to chronic pain.

Author

Kim, Ji-Young V., Megat, Salim, Moy, Jamie K., Asiedu, Marina N., Mejia, Galo L., Vagner, Josef, and Price, Theodore J.

Subjects
*CHRONIC pain treatment, *HYPERALGESIA, *GABAERGIC neurons, *NEUROPLASTICITY, *DRUG antagonism, *NEUROTROPHINS, *ANIMAL experimentation, *BIOLOGICAL models, *CHRONIC pain, *COMPARATIVE studies, *GLYCOPROTEINS, *RESEARCH methodology, *MEDICAL cooperation, *MICE, *NERVE tissue proteins, *NEURONS, *PAIN, *RESEARCH, *SPINAL cord, *EVALUATION research, *PAIN threshold
Abstract

Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pain. We find that while GABAA agonists and positive allosteric modulators reduce mechanical hypersensitivity to an acute insult, they fail to do so during the maintenance phase of hyperalgesic priming. In contrast, GABAA antagonism promotes antinociception and a reduction in facial grimacing after the transition to a chronic pain state. During the maintenance phase of hyperalgesic priming, we observed increased neuroligin (nlgn) 2 expression in the spinal dorsal horn. This protein increase was associated with an increase in nlgn2A splice variant mRNA, which promotes inhibitory synaptogenesis. Disruption of nlgn2 function with the peptide inhibitor, neurolide 2, produced mechanical hypersensitivity in naive mice but reversed hyperalgesic priming in mice previously exposed to brain-derived neurotrophic factor. Neurolide 2 treatment also reverses the change in polarity in GABAergic pharmacology observed in the maintenance of hyperalgesic priming. We propose that increased nlgn2 expression is associated with hyperalgesic priming where it promotes dysregulation of inhibitory networks. Our observations reveal new mechanisms involved in the spinal maintenance of a pain plasticity and further suggest that disinhibitory mechanisms are central features of neuroplasticity in the spinal dorsal horn. [ABSTRACT FROM AUTHOR]

Published
2016
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7. Hand infections.

Author

BROWN, DAVID M., YOUNG, V. LEROY, Brown, D M, and Young, V L

Published
1993

9. Dupuytren's contracture.

Author

RIOLO, JANE, YOUNG, V. LEROY, UEDA, KEIKO, PIDGEON, LISA, Riolo, J, Young, V L, Ueda, K, and Pidgeon, L

Published
1991

23. Calcification of breast implant capsule.

Author

YOUNG, V. LEROY, BARTELL, THOMAS, DESTOUET, JUDY M., MONSEES, BARBARA, LOGAN, SAMUEL E., Young, V L, Bartell, T, Destouet, J M, Monsees, B, and Logan, S E

Published
1989

49. Duplication of the Rectum.

Author

Stockman, J. M., Young, V. T., and Sholes, D. M.

Abstract

The subject of duplication of the rectum is reviewed and three additional cases are presented. Although duplication of the rectum is a rare anomaly, it should be suspected, especially in children with lower bowel conditions of bizarre characteristics and manifestations. [ABSTRACT FROM AUTHOR]

Published
1960
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