1. Chagas disease is an independent risk factor for stroke: baseline characteristics of a Chagas Disease cohort.
- Author
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Oliveira-Filho J, Viana LC, Vieira-de-Melo RM, Faiçal F, Torreão JA, Villar FA, and Reis FJ
- Subjects
- Adult, Aged, Amiodarone pharmacology, Anti-Arrhythmia Agents pharmacology, Anticoagulants pharmacology, Chagas Disease epidemiology, Cohort Studies, Female, Heart Diseases pathology, Humans, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Platelet Aggregation Inhibitors pharmacology, Regression Analysis, Risk Factors, Stroke complications, Stroke epidemiology, Stroke etiology, Warfarin pharmacology, Chagas Disease complications, Stroke pathology
- Abstract
Background and Purpose: Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic., Methods: We screened 305 consecutive cardiopathy patients. Significant predictors of stroke in univariable analyses were included in a multivariable model., Results: Stroke was more frequent in CD (15.0%) compared with other cardiopathies (6.3%; P=0.015). Other predictors of stroke in univariable analyses were previous diabetes or cardioversion and use of amiodarone, antiplatelet agents, and warfarin. In multivariable analysis, remaining predictors of stroke were CD (odds ratio [OR], 1.09; 95% CI, 1.02 to 1.17), cardioversion (OR, 1.07; 95% CI, 1.02 to 1.13), and diabetes (OR, 1.12; 95% CI, 1.01 to 1.24)., Conclusions: In conclusion, CD is a risk factor for stroke, independent of systolic dysfunction or presence of cardiac arrhythmias.
- Published
- 2005
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