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Start Over Author "Titiz I" Publisher lippincott williams & wilkins
8 results on '"Titiz I"'

8. Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity and lipid profile in experimental acute pancreatitis.

Author

Unal E, Uzun H, Kusaslan R, Dogan M, Genc H, Gunes P, and Titiz I

Subjects
Acute Disease, Animals, Male, Oxidative Stress, Rats, Rats, Wistar, Antioxidants analysis, Aryldialkylphosphatase blood, Lipids blood, Pancreatitis metabolism
Abstract

Objective: This study was designed to determine the serum lipid profile and the activity of paraoxonase (PON1, the lipophilic antioxidant component of high-density lipoprotein [HDL]-cholesterol) in acute pancreatitis., Methods: Acute pancreatitis was induced by injection of ethyl alcohol into the common biliary duct. Oxidative stress marker (malonyldialdehyde), lipid profile, and PON1 activity were determined in the serum., Results: In the acute pancreatitis group, whereas the mean levels of total cholesterol, low-density lipoproteins, and malonyldialdehyde were significantly higher (P < 0.001 for each), HDL level and PON1 activity were found to be significantly lower (P < 0.001 for each)., Conclusions: Our results suggest that an abnormal lipid profile and decreased PON1 activity may have a role in the pathogenesis of acute pancreatitis in which HDL-associated antioxidant defense is impaired.

Published
2005
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