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Your search keyword '"Sullivan, Keith"' showing total 24 results
Start Over Author "Sullivan, Keith" Publisher lippincott williams & wilkins
24 results on '"Sullivan, Keith"'

12. MARROW TRANSPLANTATION FROM HLA-MATCHED UNRELATED DONORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES.

Author

Beatty, Patrick G., Hansen, John A., Longton, Gary M., Thomas, E. Donnall, Sanders, Jean E., Martin, Paul J., Bearman, Scott I., Anasetti, Claudio, Petersdorf, Effie W., Mickelson, Eric M., Pepe, Margaret S., Appelbaum, Fredrick R., Buckner, C. Dean, Clift, Reginald A., Petersen, Finn Bo, Stewart, Patricia S., Storb, Rainer F., Sullivan, Keith M., Tesler, Michele C., and Witherspoon, Robert P.

Published
1991
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24. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan.

Author

Nishimura JI, Kanakura Y, Ware RE, Shichishima T, Nakakuma H, Ninomiya H, Decastro CM, Hall S, Kanamaru A, Sullivan KM, Mizoguchi H, Omine M, Kinoshita T, and Rosse WF

Subjects
Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, CD55 Antigens blood, CD59 Antigens blood, Cause of Death, Child, Child, Preschool, Female, Flow Cytometry, Hematologic Tests, Hemoglobinuria, Paroxysmal mortality, Humans, Japan epidemiology, Male, Middle Aged, Risk Factors, Survival Analysis, Survival Rate, United States epidemiology, Hemoglobinuria, Paroxysmal blood, Hemoglobinuria, Paroxysmal diagnosis
Abstract

: To determine and directly compare the clinical course of white and Asian patients with paroxysmal nocturnal hemoglobinuria (PNH), data were collected for epidemiologic analysis on 176 patients from Duke University and 209 patients from Japan. White patients were younger with significantly more classical symptoms of PNH including thrombosis, hemoglobinuria, and infection, while Asian patients were older with more marrow aplasia. The mean fraction of CD59-negative polymorphonuclear cells (PMN) at initial analysis was higher among Duke patients than Japanese patients. In both cohorts, however, a larger PNH clone was associated with classical PNH symptoms, while a smaller PNH clone was associated with marrow aplasia. Thrombosis was significantly more prevalent in white patients than Asian patients, and was associated with a significantly higher proportion of CD59-negative PMN. For individual patients, CD59-negative populations varied considerably over time, but a decreasing PNH clone portended hematopoietic failure. Survival analysis revealed a similar death rate in each group, although causes of death were different and significantly more Duke patients died from thrombosis. Japanese patients had a longer mean survival time (32.1 yr vs. 19.4 yr), although Kaplan-Meier survival curves were not significantly different. Poor survival in both groups was associated with age over 50 years, severe leukopenia/neutropenia at diagnosis, and severe infection as a complication; additionally, thrombosis at diagnosis or follow-up for Duke patients and renal failure for Japanese patients were poor prognostic factors. These data identify important differences between white and Asian patients with PNH. Identification of prognostic factors will help the design of prospective clinical trials for PNH.

Published
2004
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