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16 results on '"Siva, Aksel"'

3. Cervical spinal cord atrophy

Author

Zeydan, Burcu, Gu, Xinyi, Atkinson, Elizabeth J., Keegan, B. Mark, Weinshenker, Brian G., Tillema, Jan-Mendelt, Pelletier, Daniel, Azevedo, Christina J., Lebrun-Frenay, Christine, Siva, Aksel, Okuda, Darin T., Kantarci, Kejal, and Kantarci, Orhun H.

Subjects
Article
Abstract

Objective To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm2) of axial T2-weighted images between C2 and C7 landmarks. The midsagittal T2-weighted image from the end of C2 to the end of C7 vertebra was used to measure the cervical spine (c-spine) length (mm). Sex, age at cervical MRI, number and location of cervical spinal cord lesions, c-spine length, and diagnoses were analyzed against the outcome measures of CASA and C2 and C7 slice segmental areas. Results Intrarater and interrater agreement was excellent (intraclass correlation coefficient >0.97). The CASA area (p = 0.03) and C7 area (p = 0.002) were smaller in SPMS compared with RRMS. The C2 area (p = 0.027), CASA (p = 0.004), and C7 area (p = 0.003) were smaller in SPMS compared with RIS. The C2 area did not differ between SPMS and RRMS (p = 0.09). The C2 area (p = 0.349), CASA (p = 0.136), and C7 area (p = 0.228) did not differ between RIS and MS (SPMS and RRMS combined). In the multivariable model, ≥2 cervical spinal cord lesions were associated with the C2 area (p = 0.008), CASA (p = 0.009), and C7 area independent of disease course (p = 0.017). Progressive disease course was associated with the C7 area independent of the cervical spinal cord lesion number (p = 0.004). Conclusion Cervical spinal cord atrophy is evident at the onset of progressive MS and seems partially independent of the number of cervical spinal cord lesions. Classification of evidence This study provides Class III evidence that MRI cervical spinal cord atrophy distinguishes patients at the onset of progressive MS from those with RIS and RRMS.

Published
2018

5. Characteristics of optic neuropathy in Behçet disease.

Author

Akdal, Gülden, Toydemir, Hülya Ertaşoğlu, Saatci, Ali Osman, Uygunoğlu, Uğur, Altunrende, Burcu, Saip, Sabahattin, Yaman, Aylin, Keskinoğlu, Pembe, Yılmaz, Suzan Güven, Çelebisoy, Neşe, Bajin, Meltem Söylev, Siva, Aksel, and Akman-Demir, Gülşen

Published
2018
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15. Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

Author

Kaho B. Onomichi, Anna Tomczak, Allyson Reid, Ilya Kister, Jacinta M. Behne, Megan Kenneally Behne, Claire S Riley, Leticia Tornes, Julia J. Schubert, Jeffrey A. Cohen, Michael J. Levy, Devin S. Mullin, Jeffrey Bennett, Lawrence J. Cook, Renee R. Rodriguez, Terrence F. Blaschke, Zoe Rimler, Anthony Traboulsee, Jessica S. Alvey, Casey Engel, Derek W. Blackway, Anne Rumpf, Libby Levine, Anna Marie Jolley, Jennifer L. Sedlak, Ruth Johnson, Tanuja Chitnis, Katrina McMullen, Nancy Nealon, Brie Marron, Renee Kuhn, Mason Kruse-Hoyer, Brian Coords, Andrew W. Russo, Angela Greer, Stephen McKechnie, Terry J. Smith, Sarah M. Planchon, Melanie Marcille, Lilyana Amezcua, F. Rene Enriquez, Michael R. Yeaman, Pavle Repovic, Maureen A. Mealy, Ilana Katz Sand, Jeff Yearley, Erika Amundson, May H. Han, Lisa Eunyoung Lee, John W. Rose, Melissa Pederson, Daniel W. Behne, Robert Carruthers, Katherine E. Nelson, Ana Pruitt, Jessica Coleman, Eric C. Klawiter, Judy Sheard, Diane Ivancic, Nancy L. Sicotte, Myka Barnes-Garcia, İÜC, Neurology, Ayşe Altıntaş ( ORCID 0000-0002-8524-5087 & YÖK ID 11611), Cook, Lawrence J., Rose, John W., Alvey, Jessica S., Jolley, Anna Marie, Kuhn, Renee, Marron, Brie, Pederson, Melissa, Enriquez, Rene, Yearley, Jeff, McKechnie, Stephen, Han, May H., Tomczak, Anna J., Levy, Michael, Mealy, Maureen A., Coleman, Jessica, Bennett, Jeffrey L., Johnson, Ruth, Barnes-Garcia, Myka, Traboulsee, Anthony L., Carruthers, Robert L., Lee, Lisa Eunyoung, Schubert, Julia J., McMullen, Katrina, Kister, Ilya, Rimler, Zoe, Reid, Allyson, Sicotte, Nancy L., Planchon, Sarah M., Cohen, Jeffrey A., Ivancic, Diane, Sedlak, Jennifer L., Sand, Ilana Katz, Repovic, Pavle, Amezcua, Lilyana, Pruitt, Ana, Amundson, Erika, Chitnis, Tanuja, Mullin, Devin S., Klawiter, Eric C., Russo, Andrew W., Riley, Claire S., Onomichi, Kaho B., Levine, Libby, Nelson, Katherine E., Nealon, Nancy M., Engel, Casey, Kruse-Hoyer, Mason, Marcille, Melanie, Tornes, Leticia, Rumpf, Anne, Greer, Angela, Behne, Megan Kenneally, Rodriguez, Renee R., Behne, Daniel W., Blackway, Derek W., Coords, Brian, Blaschke, Terrence F., Sheard, Judy, Smith, Terry J., Behne, Jacinta M., Yeaman, Michael R., Abboud, Hesham, Aktas, Orhan, Altintas, Ayse, Apiwattanakul, Metha, Asgari, Nasrin, Banwell, Brenda, Bichuetti, Denis, Bowen, James, Broadley, Simon, Bruck, Wolfgang, Cabre, Philippe, Cohen, Jeffrey, De Seze, Jerome, Delgado-Garcia, Guillermo, Basuroski, Irena Dujmovic, Fujihara, Kazuo, Goodman, Andrew, Havla, Joachim, Hellwig, Kerstin, Hintzen, Rogier, Hooper, D. Craig, Iorio, Raffaele, Jacob, Anu, Jarius, Sven, Jimenez Arango, Jorge Andres, John, Gareth, Kim, Ho Jin, Kim, Sung Min, Kimbrough, Dorian J., Kissani, Najib, Kleiter, Ingo, Lana-Peixoto, Marco, Leite, M. Isabel, Liu, Yaou, Lublin, Fred, Maiga, Youssoufa, Mao-Draayer, Yang, Marignier, Romain, Matiello, Marcelo, Momtazee, Callene, Morrow, Mark, Nakashima, Ichiro, O'Connor, Kevin, Oreja-Guevara, Celia, Palace, Jacqueline, Pandit, Lekha, Paul, Friedemann, Prayoonwiwat, Naraporn, Probstel, Anne-Katrin, Qian, Peiqing, Quan, Chao, Ringelstein, Marius, Rivera, Victor, Rotstein, Dalia L., Ruprecht, Klemens, Sa, Maria Jose, Saiz, Albert, Serguera, Che, Shosha, Eslam, Siritho, Sasitorn, Siva, Aksel, Soto de Castillo, Ibis, Stuve, Olaf, Tenembaum, Silvia, Villoslada, Pablo, Wingerchuk, Dean, Wuerfel, Jens, Yeh, E. Ann, Zamvil, Scott S., Langer-Gould, Annette, School of Medicine, and Department of Neurology

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pediatrics, Biomedical Research, Internationality, MEDLINE, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, Spectrum disorder, Longitudinal Studies, Intersectoral Collaboration, International research, Neuromyelitis optica, business.industry, Neuromyelitis Optica, Middle Aged, medicine.disease, 3. Good health, 030104 developmental biology, Neurology, Cohort, Medicine, Clinical neurology, Neurosciences, Female, Observational study, Neurology (clinical), Function and Dysfunction of the Nervous System, business, 030217 neurology & neurosurgery, Neuromyelitis-optica, Diagnostic-criteria, Prevalence, Multicenter, Disorders, Features, Cohort study
Abstract

Objective to develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. Methods to illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. Results as of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. Conclusions collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD., The Guthy-Jackson Charitable Foundation, The CIRCLES Project

Published
2019

16. Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorder Patients in Turkish Cohort: Demographic, Clinical, and Laboratory Features.

Author

Altintas A, Karabudak R, Balci BP, Terzi M, Soysal A, Saip S, Tuncer Kurne A, Uygunoglu U, Nalbantoglu M, Gozubatik Celik G, Isik N, Celik Y, Gokcay F, Duman T, Boz C, Yucesan C, Mangan MS, Celebisoy N, Diker S, Colpak Isikay I, Kansu T, and Siva A

Subjects
Adolescent, Adult, Age of Onset, Aged, Anti-Inflammatory Agents therapeutic use, Aquaporin 4 immunology, Cohort Studies, Disability Evaluation, Disease Progression, Female, Humans, Immunoglobulin G blood, Magnetic Resonance Imaging, Male, Methylprednisolone therapeutic use, Middle Aged, Turkey epidemiology, Young Adult, Demography statistics & numerical data, Neuromyelitis Optica diagnosis, Neuromyelitis Optica epidemiology, Neuromyelitis Optica therapy
Abstract

Background: Neuromyelitis optica (NMO) is an immune-mediated, chronic relapsing, inflammatory disease characterized by severe attacks of optic neuritis and myelitis., Objective: To determine the demographic, clinical, and laboratory features; antibody status; and treatment modalities of patients with NMO and neuromyelitis optica spectrum disorders in a Turkish cohort from 11 centers., Methods: A total of 182 patients were included in this study. Data on age at disease onset, sex, type of attacks, clinical presentation, analysis of cerebrospinal fluid, serum antiaquaporin-4 antibody status, annual progression index, and medical and family histories were collected., Results: Mean age was 38.43±12.40 years (range, 13 to 75 y), and mean age at disease onset was 31.29±12.40 years (median, 29 y; range, 10 to 74 y). In NMO group, the rate of NMO immunoglobulin (Ig)G positivity was 62.5%. The annual progression index was significantly higher in the longitudinally extending spinal cord lesion. The mean Expanded Disability Status Scale score was higher in the late than early-onset NMO group., Conclusion: Our results revealed a lower rate of NMO IgG positivity, more severe disability in patients with NMO/neuromyelitis optica spectrum disorders presenting with either transverse myelitis or late-onset NMO, and no correlation between disability and NMO IgG status.

Published
2015
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