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Background: Geoffrey Rose's paper "Sick Individuals, Sick Populations" highlights the counterintuitive finding that the largest share of morbidity arises from populations engaging in low- to moderate-risk behavior. Scholars refer to this finding as the prevention paradox. We examine whether this logic applies to SARS-CoV-2 infected persons considered low to moderate risk.Methods: We conducted a population-representative survey and sero-surveillance study for SARS-CoV-2 among adults in Orange County, California. Participants answered questions about health behaviors and provided a finger pin-prick sample from 10 July-16 August 2020.Results: Of the 2,979 adults, those reporting low- and moderate- risk behavior accounted for between 78% to 92% of SARS-CoV-2 infections. Asymptomatic individuals, as well as persons with low- and moderate- scores for self-reported likelihood of having had SARS-CoV-2, accounted for the majority of infections.Conclusions: Our findings support Rose's logic, which encourages public health measures among persons who self-identify as unlikely to have SARS-CoV-2. [ABSTRACT FROM AUTHOR]

The article discusses the results of a study which examines the effect of hemodynamic correction using ventricular assist device (VAD) placement on patients with advanced heart failure (HF). The results showed that serum adiponectin reduced while insulin resistance improved in patients after VAD implantation. The expression of adiponectin in adipose tissue also reduced after VAD placement. Macrophage infiltration in adipose tissue became normal after VAD placement.

The article compares the impact of using continuous-flow (C) and pulsatile-flow (P) left ventricular assist devices (LVAD) for myocardial unloading and remodeling. The 61 post LVAD implantation patients observed showed the group who used the P device registered lower postoperative LV ejection fraction and mitral E/E' compared to those who used continuous-flow LVAD. The authors conclude that pulsatile mechanical unloading of the myocardium should be considered during device selection.