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Your search keyword '"Sievers, Richard E."' showing total 12 results
Start Over Author "Sievers, Richard E." Publisher lippincott williams & wilkins
12 results on '"Sievers, Richard E."'

12. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

Author

Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, and Moons L

Subjects
Angiogenesis Inducing Agents metabolism, Animals, Coronary Vessels drug effects, Coronary Vessels physiopathology, Disease Models, Animal, Gene Transfer Techniques, Genetic Therapy methods, Hindlimb, Ischemia pathology, Ischemia physiopathology, Ischemia therapy, Lung blood supply, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Muscle, Skeletal blood supply, Myocardial Ischemia pathology, Myocardial Ischemia physiopathology, Myocardial Ischemia therapy, Myocardium pathology, Recombinant Proteins metabolism, Retinal Vessels metabolism, Skin blood supply, Up-Regulation, Vascular Endothelial Growth Factor B administration & dosage, Vascular Endothelial Growth Factor B deficiency, Vascular Endothelial Growth Factor B genetics, Vascular Endothelial Growth Factor Receptor-1 metabolism, Coronary Vessels metabolism, Ischemia metabolism, Myocardial Ischemia metabolism, Myocardium metabolism, Neovascularization, Physiologic drug effects, Vascular Endothelial Growth Factor B metabolism
Abstract

Objective: The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear., Methods and Results: We studied the role of VEGF-B in various models of pathological angiogenesis using mice lacking VEGF-B (VEGF-B(-/-)) or overexpressing VEGF-B(167). After occlusion of the left coronary artery, VEGF-B deficiency impaired vessel growth in the ischemic myocardium whereas, in wild-type mice, VEGF-B(167) overexpression enhanced revascularization of the infarct and ischemic border zone. By contrast, VEGF-B deficiency did not affect vessel growth in the wounded skin, hypoxic lung, ischemic retina, or ischemic limb. Moreover, VEGF-B(167) overexpression failed to enhance vascular growth in the skin or ischemic limb., Conclusions: VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. These insights might offer novel therapeutic opportunities.

Published
2008
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